Exosomal Del-1 as a Potent Diagnostic Marker for Breast Cancer: Prospective Cohort Study

Soo Jung Lee, Jeeyeon Lee, Jin Hyang Jung, Ho Yong Park, Pyong Gon Moon, Yee Soo Chae, Moon Chang Baek

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20 Scopus citations

Abstract

Background: The differential diagnostic role of plasma developmental endothelial locus-1 (Del-1) was proposed in our previous study. Therefore the current study aimed to confirm the diagnostic role and explore the prognostic role of exosomal Del-1 in a prospective cohort of female patients with breast cancer. Patients and Methods: To determine the optimal sampling time for the postoperative Del-1 measurements, blood was serially collected on days 1, 3, 5, and 7 after surgery in 22 patients (cohort 1). Thereafter, 111 female patients with breast cancer were prospectively enrolled (cohort 2) to compare exosomal Del-1 levels before and after surgery. Results: Among the subsequent prospective cohort, 107 patients (96.4%) showed a high exosomal Del-1 level (optical density [OD] value > 0.5) at the time of diagnosis. Of these patients, 101 (94.6%) in this high-level group showed normalized Del-1 levels postoperatively, representing a significant difference (mean OD value, 1.232 vs. 0.196; P < .00001). High postoperative Del-1 level was significantly associated with a worse disease-free survival adjusted to the clinicopathological characteristics (hazard ratio, 24.0; P = .0011). Conclusion: This study confirmed the normalization of exosomal Del-1 after surgery, indicating exosomal Del-1 as a potent diagnostic biomarker for breast cancer. In addition, because a high Del-1 level after surgery was associated with early relapse, this suggests exosomal Del-1 as a potential prognostic marker by identifying the existence of residual cancer.

Original languageEnglish
Pages (from-to)e748-e756
JournalClinical Breast Cancer
Volume21
Issue number6
DOIs
StatePublished - Dec 2021

Keywords

  • Biomarker
  • Blood-based biomarker
  • Diagnostic biomarker
  • Early breast cancer
  • Exosome

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