Exosomal noncoding RNA: A potential therapy for retinal vascular diseases

Jong Ik Heo, Juhee Ryu

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Exosomes are extracellular vesicles that can contain DNA, RNA, proteins, and metabolites. They are secreted by cells and play a regulatory role in various biological responses by mediating cell-to-cell communication. Moreover, exosomes are of interest in developing therapies for retinal vascular disorders because they can deliver various substances to cellular targets. According to recent research, exosomes can be used as a strategy for managing retinal vascular diseases, and they are being investigated for therapeutic purposes in eye conditions, including glaucoma, dry eye syndrome, retinal ischemia, diabetic retinopathy, and age-related macular degeneration. However, the role of exosomal noncoding RNA in retinal vascular diseases is not fully understood. Here, we reviewed the latest research on the biological role of exosomal noncoding RNA in treating retinal vascular diseases. Research has shown that noncoding RNAs, including microRNAs, circular RNAs, and long noncoding RNAs play a significant role in the regulation of retinal vascular diseases. Furthermore, through exosome engineering, the expression of relevant noncoding RNAs in exosomes can be controlled to regulate retinal vascular diseases. Therefore, this review suggests that exosomal noncoding RNA could be considered as a biomarker for diagnosis and as a therapeutic target for treating retinal vascular disease.

Original languageEnglish
Article number102128
JournalMolecular Therapy Nucleic Acids
Volume35
Issue number1
DOIs
StatePublished - 12 Mar 2024

Keywords

  • MT: Novel therapeutic targets and biomarker development Special Issue
  • circular RNA
  • exosomal RNA
  • long noncoding RNA
  • microRNA
  • noncoding RNA
  • retinal vascular disease

Fingerprint

Dive into the research topics of 'Exosomal noncoding RNA: A potential therapy for retinal vascular diseases'. Together they form a unique fingerprint.

Cite this