Experimental Infection of Chickens with Intercontinental Reassortant H9N2 Influenza Viruses from Wild Birds

Dong Hun Lee, Jung Hoon Kwon, Jae Keun Park, Seong Su Yuk, Erdene Ochir Tseren-Ochir, Jin Yong Noh, Joong Bok Lee, Seung Yong Park, In Soo Choi, Chang Seon Song

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The H9N2 subtype of low pathogenic avian influenza (LPAI) virus is the most prevalent LPAI in domestic poultry. We previously reported the natural reassortant H9N2 viruses between North American and Eurasian lineages isolated from wild birds in Korea. These viruses were identified in China and Alaska, providing evidence of intercontinental dispersal. In this study, we evaluated the infectivity, transmissibility, and pathogenic potential of these H9N2 viruses and Eurasian H9N2 virus identified from wild birds using specific-pathogen-free chickens. Three-week-old chickens were infected intranasally. All of these reassortant H9N2 viruses could not be replicated and transmitted in chickens. On the other hand, three out of eight chickens inoculated with the Eurasian H9N2 virus shed detectable levels of virus and showed seroconversion but did not show contact transmission of the virus. Although all reassortant H9N2 viruses could not be replicated and transmitted in chickens, and although there are no reports on reassortant H9N2 virus infection in poultry farms until now, monitoring of reassortant H9N2 viruses should be continued to prepare for the advent and evolution of these viruses.

Original languageEnglish
Pages (from-to)493-495
Number of pages3
JournalAvian Diseases
Volume60
Issue number2
DOIs
StatePublished - Jun 2016

Keywords

  • Avian influenza virus
  • chicken
  • H9N2
  • wild bird

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