Abstract
Extracellular vesicles, particularly exosomes, have emerged as promising drug delivery systems owing to their unique advantages, such as biocompatibility, immune tolerability, and target specificity. Various engineering strategies have been implemented to harness these innate qualities, with a focus on enhancing the pharmacokinetic and pharmacodynamic properties of exosomes via payload loading and surface engineering for active targeting. This concise review outlines the challenges in the development of exosomes as drug carriers and offers insights into strategies for their effective clinical translation. We also highlight preclinical studies that have successfully employed anti-inflammatory exosomes and suggest future directions for exosome therapeutics. These advancements underscore the potential for integrating exosome-based therapies into clinical practice, heralding promise for future medical interventions.
Original language | English |
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Pages (from-to) | 637-647 |
Number of pages | 11 |
Journal | Stem cells translational medicine |
Volume | 13 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2024 |
Keywords
- drug delivery system
- exosome purification
- exosomes
- extracellular vesicles
- inflammation
- protein therapeutics