Exploring the clinical transition of engineered exosomes designed for intracellular delivery of therapeutic proteins

Minseong Kim, Hojun Choi, Deok Jin Jang, Hye Jung Kim, Yujin Sub, Heon Yung Gee, Chulhee Choi

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Extracellular vesicles, particularly exosomes, have emerged as promising drug delivery systems owing to their unique advantages, such as biocompatibility, immune tolerability, and target specificity. Various engineering strategies have been implemented to harness these innate qualities, with a focus on enhancing the pharmacokinetic and pharmacodynamic properties of exosomes via payload loading and surface engineering for active targeting. This concise review outlines the challenges in the development of exosomes as drug carriers and offers insights into strategies for their effective clinical translation. We also highlight preclinical studies that have successfully employed anti-inflammatory exosomes and suggest future directions for exosome therapeutics. These advancements underscore the potential for integrating exosome-based therapies into clinical practice, heralding promise for future medical interventions.

Original languageEnglish
Pages (from-to)637-647
Number of pages11
JournalStem cells translational medicine
Volume13
Issue number7
DOIs
StatePublished - Jul 2024

Keywords

  • drug delivery system
  • exosome purification
  • exosomes
  • extracellular vesicles
  • inflammation
  • protein therapeutics

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