Expression of cytokeratins 8 and 18 on Mallory body and oval cell in rats during hepatic fibrosis

Won Il Jeong; Da Hee Jeong; Sun Hee Do; Hai Jie Yang; Il Hwa Hong; Seong Joon Chang; Dong Wei Yuan; Dong Mi Kwak; Tae Hwan Kim; Yoo Kyeong Kim; In Seon Lee; Kyu Shik Jeong

Expression of cytokeratins 8 and 18 on Mallory body and oval cell in rats during hepatic fibrosis

Won Il Jeong, Da Hee Jeong, Sun Hee Do, Hai Jie Yang, Il Hwa Hong, Seong Joon Chang, Dong Wei Yuan, Dong Mi Kwak, Tae Hwan Kim, Yoo Kyeong Kim, In Seon Lee, Kyu Shik Jeong

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: The aim of this study was to determine the induction and distribution of Mallory body (MB) and oval cells in carbon-tetrachloride (CCl₄)-induced rat liver fibrosis. Materials and methods: MBs and oval cells expressing cytokeratins (CKs) 8 and 18 were monitored by immunohistochemistry and immunoblotting. Results: MBs were mainly detected within hepatocytes near the fibrotic areas, and oval cells were located along or in the fibrotic areas. Both MBs and oval cells increased in size and number in the development of fibrosis. At cirrhotic liver, most of the oval cells were located in the fibrous septa and around newly formed bile ductules. Moreover, as hepatic injuries developed into fibrosis, a much more prominent single band of CK18 was detected. Conclusion: The occurrence and distribution of MB and oval cells in CCl₄-induced rat liver fibrosis are reported. This represents the first CCl₄ experimental in vivo model of MB induction, which will be useful for further investigations on the pathogenesis of MB.

Original language	English
Pages (from-to)	769-776
Number of pages	8
Journal	In Vivo
Volume	19
Issue number	4
State	Published - 2005

Keywords

CK18
CK8
Hepatic fibrosis
Mallory body
Oval cell

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{71f41b1e34d8434998c6905354a15ecf,

title = "Expression of cytokeratins 8 and 18 on Mallory body and oval cell in rats during hepatic fibrosis",

abstract = "Background: The aim of this study was to determine the induction and distribution of Mallory body (MB) and oval cells in carbon-tetrachloride (CCl4)-induced rat liver fibrosis. Materials and methods: MBs and oval cells expressing cytokeratins (CKs) 8 and 18 were monitored by immunohistochemistry and immunoblotting. Results: MBs were mainly detected within hepatocytes near the fibrotic areas, and oval cells were located along or in the fibrotic areas. Both MBs and oval cells increased in size and number in the development of fibrosis. At cirrhotic liver, most of the oval cells were located in the fibrous septa and around newly formed bile ductules. Moreover, as hepatic injuries developed into fibrosis, a much more prominent single band of CK18 was detected. Conclusion: The occurrence and distribution of MB and oval cells in CCl4-induced rat liver fibrosis are reported. This represents the first CCl4 experimental in vivo model of MB induction, which will be useful for further investigations on the pathogenesis of MB.",

keywords = "CK18, CK8, Hepatic fibrosis, Mallory body, Oval cell",

author = "Jeong, {Won Il} and Jeong, {Da Hee} and Do, {Sun Hee} and Yang, {Hai Jie} and Hong, {Il Hwa} and Chang, {Seong Joon} and Yuan, {Dong Wei} and Kwak, {Dong Mi} and Kim, {Tae Hwan} and Kim, {Yoo Kyeong} and Lee, {In Seon} and Jeong, {Kyu Shik}",

year = "2005",

language = "English",

volume = "19",

pages = "769--776",

journal = "In Vivo",

issn = "0258-851X",

publisher = "International Institute of Anticancer Research",

number = "4",

}

TY - JOUR

T1 - Expression of cytokeratins 8 and 18 on Mallory body and oval cell in rats during hepatic fibrosis

AU - Jeong, Won Il

AU - Jeong, Da Hee

AU - Do, Sun Hee

AU - Yang, Hai Jie

AU - Hong, Il Hwa

AU - Chang, Seong Joon

AU - Yuan, Dong Wei

AU - Kwak, Dong Mi

AU - Kim, Tae Hwan

AU - Kim, Yoo Kyeong

AU - Lee, In Seon

AU - Jeong, Kyu Shik

PY - 2005

Y1 - 2005

N2 - Background: The aim of this study was to determine the induction and distribution of Mallory body (MB) and oval cells in carbon-tetrachloride (CCl4)-induced rat liver fibrosis. Materials and methods: MBs and oval cells expressing cytokeratins (CKs) 8 and 18 were monitored by immunohistochemistry and immunoblotting. Results: MBs were mainly detected within hepatocytes near the fibrotic areas, and oval cells were located along or in the fibrotic areas. Both MBs and oval cells increased in size and number in the development of fibrosis. At cirrhotic liver, most of the oval cells were located in the fibrous septa and around newly formed bile ductules. Moreover, as hepatic injuries developed into fibrosis, a much more prominent single band of CK18 was detected. Conclusion: The occurrence and distribution of MB and oval cells in CCl4-induced rat liver fibrosis are reported. This represents the first CCl4 experimental in vivo model of MB induction, which will be useful for further investigations on the pathogenesis of MB.

AB - Background: The aim of this study was to determine the induction and distribution of Mallory body (MB) and oval cells in carbon-tetrachloride (CCl4)-induced rat liver fibrosis. Materials and methods: MBs and oval cells expressing cytokeratins (CKs) 8 and 18 were monitored by immunohistochemistry and immunoblotting. Results: MBs were mainly detected within hepatocytes near the fibrotic areas, and oval cells were located along or in the fibrotic areas. Both MBs and oval cells increased in size and number in the development of fibrosis. At cirrhotic liver, most of the oval cells were located in the fibrous septa and around newly formed bile ductules. Moreover, as hepatic injuries developed into fibrosis, a much more prominent single band of CK18 was detected. Conclusion: The occurrence and distribution of MB and oval cells in CCl4-induced rat liver fibrosis are reported. This represents the first CCl4 experimental in vivo model of MB induction, which will be useful for further investigations on the pathogenesis of MB.

KW - CK18

KW - CK8

KW - Hepatic fibrosis

KW - Mallory body

KW - Oval cell

UR - http://www.scopus.com/inward/record.url?scp=21344451441&partnerID=8YFLogxK

M3 - Article

C2 - 15999547

AN - SCOPUS:21344451441

SN - 0258-851X

VL - 19

SP - 769

EP - 776

JO - In Vivo

JF - In Vivo

IS - 4

ER -

Expression of cytokeratins 8 and 18 on Mallory body and oval cell in rats during hepatic fibrosis

Abstract

Keywords

UN SDGs

Other files and links

Fingerprint

Cite this