Expression of hepatitis C virus nonstructural 4B in transgenic mice

Ai Guo Wang; Hyung Bae Moon; Jin Man Kim; Soon Bong Hwang; Dae Yeul Yu; Dong Seok Lee

doi:10.1038/emm.2006.29

Expression of hepatitis C virus nonstructural 4B in transgenic mice

Ai Guo Wang, Hyung Bae Moon, Jin Man Kim, Soon Bong Hwang, Dae Yeul Yu, Dong Seok Lee

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Hepatitis C virus (HCV) is a pathogen that is of great medical significance in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. Although the HCV proteins have been intensively investigated over the past decade, the biochemical functions of the NS4B protein are still largely unknown. To investigate NS4B as a potential causative agent of liver disease, transgenic mice expressing the NS4B protein in liver tissue were produced. The transgenic animals were phenotypically similar to their normal littermates for up to 18 months of age. Our results suggest that the HCV NS4B protein is not directly cytopathic or oncogenic in our transgenic mice model.

Original language	English
Pages (from-to)	241-246
Number of pages	6
Journal	Experimental and Molecular Medicine
Volume	38
Issue number	3
DOIs	https://doi.org/10.1038/emm.2006.29
State	Published - 30 Jun 2006

Keywords

Hepacivirus
Liver
Mice, transgenic
Ns4 protein, hepatitis C virus
Viral nonstructural proteins

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/emm.2006.29

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title = "Expression of hepatitis C virus nonstructural 4B in transgenic mice",

abstract = "Hepatitis C virus (HCV) is a pathogen that is of great medical significance in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. Although the HCV proteins have been intensively investigated over the past decade, the biochemical functions of the NS4B protein are still largely unknown. To investigate NS4B as a potential causative agent of liver disease, transgenic mice expressing the NS4B protein in liver tissue were produced. The transgenic animals were phenotypically similar to their normal littermates for up to 18 months of age. Our results suggest that the HCV NS4B protein is not directly cytopathic or oncogenic in our transgenic mice model.",

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T1 - Expression of hepatitis C virus nonstructural 4B in transgenic mice

AU - Wang, Ai Guo

AU - Moon, Hyung Bae

AU - Kim, Jin Man

AU - Hwang, Soon Bong

AU - Yu, Dae Yeul

AU - Lee, Dong Seok

PY - 2006/6/30

Y1 - 2006/6/30

N2 - Hepatitis C virus (HCV) is a pathogen that is of great medical significance in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. Although the HCV proteins have been intensively investigated over the past decade, the biochemical functions of the NS4B protein are still largely unknown. To investigate NS4B as a potential causative agent of liver disease, transgenic mice expressing the NS4B protein in liver tissue were produced. The transgenic animals were phenotypically similar to their normal littermates for up to 18 months of age. Our results suggest that the HCV NS4B protein is not directly cytopathic or oncogenic in our transgenic mice model.

AB - Hepatitis C virus (HCV) is a pathogen that is of great medical significance in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. Although the HCV proteins have been intensively investigated over the past decade, the biochemical functions of the NS4B protein are still largely unknown. To investigate NS4B as a potential causative agent of liver disease, transgenic mice expressing the NS4B protein in liver tissue were produced. The transgenic animals were phenotypically similar to their normal littermates for up to 18 months of age. Our results suggest that the HCV NS4B protein is not directly cytopathic or oncogenic in our transgenic mice model.

KW - Hepacivirus

KW - Liver

KW - Mice, transgenic

KW - Ns4 protein, hepatitis C virus

KW - Viral nonstructural proteins

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SP - 241

EP - 246

JO - Experimental and Molecular Medicine

JF - Experimental and Molecular Medicine

IS - 3

ER -

Expression of hepatitis C virus nonstructural 4B in transgenic mice

Abstract

Keywords

UN SDGs

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