Extended release of growth factor from thermosensitive copolymer hydrogels

J. H. Choi, Y. A. Han, B. C. Ji, J. O. Lim

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The synthesis of N-isopropyl acrylamide (NIPAAm) and sodium methacrylate (SMA) copolymer hydrogels was studied. The characteristics of these copolymer hydrogels such as swelling/deswelling behavior were also analyzed. It was observed that poly(NIPAAm-co-SMA) hydrogel crosslinked with poly(ethylene glycol) diacrylate showed higher water content than poly(NIPAAm) hydrogel at 37 °C, which was resulting in higher amount of basic fibroblast growth factor(bFGF) release. The results show that thermosensitive hydrogel synthesized with a hydrophilic comonomer and a long crosslinking agent enables an extended release of growth factor such as bFGF.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Pages255
Number of pages1
StatePublished - 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: 17 May 200421 May 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Conference

ConferenceTransactions - 7th World Biomaterials Congress
Country/TerritoryAustralia
CitySydney
Period17/05/0421/05/04

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