Extracts of Phellinus gilvus and Phellinus baumii inhibit pulmonary inflammation induced by lipopolysaccharide in rats

Beom Su Jang; Jong Chun Kim; Jae Sung Bae; Man Hee Rhee; Kwang Ho Jang; Jae Chan Song; Oh Deog Kwon; Seung Chun Park

doi:10.1023/B:BILE.0000009456.63616.32

Extracts of Phellinus gilvus and Phellinus baumii inhibit pulmonary inflammation induced by lipopolysaccharide in rats

Beom Su Jang, Jong Chun Kim, Jae Sung Bae, Man Hee Rhee, Kwang Ho Jang, Jae Chan Song, Oh Deog Kwon, Seung Chun Park

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Compared to saline-challenged rats, rats exposed to 50 μg intratracheal lipopolysaccharide showed an increase of total white cells (from 0.3 × 10⁶ to 2.4 × 10⁶), neutrophils (from 0.09 × 10⁶ to 1.8 × 10⁶), the levels of tumor necrosis factor (TNF)-α (from 200 pg ml^-1 to 1200 pg ml^-1), and interleukin (IL)-1β (from 220 pg ml^-1 to 650 pg ml ^-1) in the bronchial lavage fluid. However, after pretreatment with extracts of Phellinus gilvus and Phellinus baumii, the total white cells, neutrophils, and the level of IL-1β in lipopolysaccharide-challenged rats were similar to those in saline-challenged rats, except for TNF-α. The results indicate that extracts of P. gilvus and P. baumii may be useful in preventing acute pulmonary inflammation in human diseases.

Original language	English
Pages (from-to)	31-33
Number of pages	3
Journal	Biotechnology Letters
Volume	26
Issue number	1
DOIs	https://doi.org/10.1023/B:BILE.0000009456.63616.32
State	Published - Jan 2004

Keywords

Inflammation
Neutrophilia
Phellinus baumii
Phellinus gilvus
Rats

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1023/B:BILE.0000009456.63616.32

Cite this

@article{1412f36adef6491c91f01286a2f9ffed,

title = "Extracts of Phellinus gilvus and Phellinus baumii inhibit pulmonary inflammation induced by lipopolysaccharide in rats",

abstract = "Compared to saline-challenged rats, rats exposed to 50 μg intratracheal lipopolysaccharide showed an increase of total white cells (from 0.3 × 106 to 2.4 × 106), neutrophils (from 0.09 × 106 to 1.8 × 106), the levels of tumor necrosis factor (TNF)-α (from 200 pg ml-1 to 1200 pg ml-1), and interleukin (IL)-1β (from 220 pg ml-1 to 650 pg ml -1) in the bronchial lavage fluid. However, after pretreatment with extracts of Phellinus gilvus and Phellinus baumii, the total white cells, neutrophils, and the level of IL-1β in lipopolysaccharide-challenged rats were similar to those in saline-challenged rats, except for TNF-α. The results indicate that extracts of P. gilvus and P. baumii may be useful in preventing acute pulmonary inflammation in human diseases.",

keywords = "Inflammation, Neutrophilia, Phellinus baumii, Phellinus gilvus, Rats",

author = "Jang, {Beom Su} and Kim, {Jong Chun} and Bae, {Jae Sung} and Rhee, {Man Hee} and Jang, {Kwang Ho} and Song, {Jae Chan} and Kwon, {Oh Deog} and Park, {Seung Chun}",

year = "2004",

month = jan,

doi = "10.1023/B:BILE.0000009456.63616.32",

language = "English",

volume = "26",

pages = "31--33",

journal = "Biotechnology Letters",

issn = "0141-5492",

publisher = "Springer Science and Business Media B.V.",

number = "1",

}

TY - JOUR

T1 - Extracts of Phellinus gilvus and Phellinus baumii inhibit pulmonary inflammation induced by lipopolysaccharide in rats

AU - Jang, Beom Su

AU - Kim, Jong Chun

AU - Bae, Jae Sung

AU - Rhee, Man Hee

AU - Jang, Kwang Ho

AU - Song, Jae Chan

AU - Kwon, Oh Deog

AU - Park, Seung Chun

PY - 2004/1

Y1 - 2004/1

N2 - Compared to saline-challenged rats, rats exposed to 50 μg intratracheal lipopolysaccharide showed an increase of total white cells (from 0.3 × 106 to 2.4 × 106), neutrophils (from 0.09 × 106 to 1.8 × 106), the levels of tumor necrosis factor (TNF)-α (from 200 pg ml-1 to 1200 pg ml-1), and interleukin (IL)-1β (from 220 pg ml-1 to 650 pg ml -1) in the bronchial lavage fluid. However, after pretreatment with extracts of Phellinus gilvus and Phellinus baumii, the total white cells, neutrophils, and the level of IL-1β in lipopolysaccharide-challenged rats were similar to those in saline-challenged rats, except for TNF-α. The results indicate that extracts of P. gilvus and P. baumii may be useful in preventing acute pulmonary inflammation in human diseases.

AB - Compared to saline-challenged rats, rats exposed to 50 μg intratracheal lipopolysaccharide showed an increase of total white cells (from 0.3 × 106 to 2.4 × 106), neutrophils (from 0.09 × 106 to 1.8 × 106), the levels of tumor necrosis factor (TNF)-α (from 200 pg ml-1 to 1200 pg ml-1), and interleukin (IL)-1β (from 220 pg ml-1 to 650 pg ml -1) in the bronchial lavage fluid. However, after pretreatment with extracts of Phellinus gilvus and Phellinus baumii, the total white cells, neutrophils, and the level of IL-1β in lipopolysaccharide-challenged rats were similar to those in saline-challenged rats, except for TNF-α. The results indicate that extracts of P. gilvus and P. baumii may be useful in preventing acute pulmonary inflammation in human diseases.

KW - Inflammation

KW - Neutrophilia

KW - Phellinus baumii

KW - Phellinus gilvus

KW - Rats

UR - http://www.scopus.com/inward/record.url?scp=0842288724&partnerID=8YFLogxK

U2 - 10.1023/B:BILE.0000009456.63616.32

DO - 10.1023/B:BILE.0000009456.63616.32

M3 - Article

C2 - 15005148

AN - SCOPUS:0842288724

SN - 0141-5492

VL - 26

SP - 31

EP - 33

JO - Biotechnology Letters

JF - Biotechnology Letters

IS - 1

ER -

Extracts of Phellinus gilvus and Phellinus baumii inhibit pulmonary inflammation induced by lipopolysaccharide in rats

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this