Extracts of Phellinus gilvus and Phellinus baumii inhibit pulmonary inflammation induced by lipopolysaccharide in rats

Beom Su Jang; Jong Chun Kim; Jae Sung Bae; Man Hee Rhee; Kwang Ho Jang; Jae Chan Song; Oh Deog Kwon; Seung Chun Park

doi:10.1023/B:BILE.0000009456.63616.32

Extracts of Phellinus gilvus and Phellinus baumii inhibit pulmonary inflammation induced by lipopolysaccharide in rats

Beom Su Jang
, Jong Chun Kim
, Jae Sung Bae
, Man Hee Rhee
, Kwang Ho Jang
, Jae Chan Song
, Oh Deog Kwon
, Seung Chun Park

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Compared to saline-challenged rats, rats exposed to 50 μg intratracheal lipopolysaccharide showed an increase of total white cells (from 0.3 × 10⁶ to 2.4 × 10⁶), neutrophils (from 0.09 × 10⁶ to 1.8 × 10⁶), the levels of tumor necrosis factor (TNF)-α (from 200 pg ml^-1 to 1200 pg ml^-1), and interleukin (IL)-1β (from 220 pg ml^-1 to 650 pg ml ^-1) in the bronchial lavage fluid. However, after pretreatment with extracts of Phellinus gilvus and Phellinus baumii, the total white cells, neutrophils, and the level of IL-1β in lipopolysaccharide-challenged rats were similar to those in saline-challenged rats, except for TNF-α. The results indicate that extracts of P. gilvus and P. baumii may be useful in preventing acute pulmonary inflammation in human diseases.

Original language	English
Pages (from-to)	31-33
Number of pages	3
Journal	Biotechnology Letters
Volume	26
Issue number	1
DOIs	https://doi.org/10.1023/B:BILE.0000009456.63616.32
State	Published - Jan 2004

Keywords

Inflammation
Neutrophilia
Phellinus baumii
Phellinus gilvus
Rats

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1023/B:BILE.0000009456.63616.32

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title = "Extracts of Phellinus gilvus and Phellinus baumii inhibit pulmonary inflammation induced by lipopolysaccharide in rats",

abstract = "Compared to saline-challenged rats, rats exposed to 50 μg intratracheal lipopolysaccharide showed an increase of total white cells (from 0.3 × 106 to 2.4 × 106), neutrophils (from 0.09 × 106 to 1.8 × 106), the levels of tumor necrosis factor (TNF)-α (from 200 pg ml-1 to 1200 pg ml-1), and interleukin (IL)-1β (from 220 pg ml-1 to 650 pg ml -1) in the bronchial lavage fluid. However, after pretreatment with extracts of Phellinus gilvus and Phellinus baumii, the total white cells, neutrophils, and the level of IL-1β in lipopolysaccharide-challenged rats were similar to those in saline-challenged rats, except for TNF-α. The results indicate that extracts of P. gilvus and P. baumii may be useful in preventing acute pulmonary inflammation in human diseases.",

keywords = "Inflammation, Neutrophilia, Phellinus baumii, Phellinus gilvus, Rats",

author = "Jang, \{Beom Su\} and Kim, \{Jong Chun\} and Bae, \{Jae Sung\} and Rhee, \{Man Hee\} and Jang, \{Kwang Ho\} and Song, \{Jae Chan\} and Kwon, \{Oh Deog\} and Park, \{Seung Chun\}",

year = "2004",

month = jan,

doi = "10.1023/B:BILE.0000009456.63616.32",

language = "English",

volume = "26",

pages = "31--33",

journal = "Biotechnology Letters",

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}

TY - JOUR

T1 - Extracts of Phellinus gilvus and Phellinus baumii inhibit pulmonary inflammation induced by lipopolysaccharide in rats

AU - Jang, Beom Su

AU - Kim, Jong Chun

AU - Bae, Jae Sung

AU - Rhee, Man Hee

AU - Jang, Kwang Ho

AU - Song, Jae Chan

AU - Kwon, Oh Deog

AU - Park, Seung Chun

PY - 2004/1

Y1 - 2004/1

N2 - Compared to saline-challenged rats, rats exposed to 50 μg intratracheal lipopolysaccharide showed an increase of total white cells (from 0.3 × 106 to 2.4 × 106), neutrophils (from 0.09 × 106 to 1.8 × 106), the levels of tumor necrosis factor (TNF)-α (from 200 pg ml-1 to 1200 pg ml-1), and interleukin (IL)-1β (from 220 pg ml-1 to 650 pg ml -1) in the bronchial lavage fluid. However, after pretreatment with extracts of Phellinus gilvus and Phellinus baumii, the total white cells, neutrophils, and the level of IL-1β in lipopolysaccharide-challenged rats were similar to those in saline-challenged rats, except for TNF-α. The results indicate that extracts of P. gilvus and P. baumii may be useful in preventing acute pulmonary inflammation in human diseases.

AB - Compared to saline-challenged rats, rats exposed to 50 μg intratracheal lipopolysaccharide showed an increase of total white cells (from 0.3 × 106 to 2.4 × 106), neutrophils (from 0.09 × 106 to 1.8 × 106), the levels of tumor necrosis factor (TNF)-α (from 200 pg ml-1 to 1200 pg ml-1), and interleukin (IL)-1β (from 220 pg ml-1 to 650 pg ml -1) in the bronchial lavage fluid. However, after pretreatment with extracts of Phellinus gilvus and Phellinus baumii, the total white cells, neutrophils, and the level of IL-1β in lipopolysaccharide-challenged rats were similar to those in saline-challenged rats, except for TNF-α. The results indicate that extracts of P. gilvus and P. baumii may be useful in preventing acute pulmonary inflammation in human diseases.

KW - Inflammation

KW - Neutrophilia

KW - Phellinus baumii

KW - Phellinus gilvus

KW - Rats

UR - https://www.scopus.com/pages/publications/0842288724

U2 - 10.1023/B:BILE.0000009456.63616.32

DO - 10.1023/B:BILE.0000009456.63616.32

M3 - Article

C2 - 15005148

AN - SCOPUS:0842288724

SN - 0141-5492

VL - 26

SP - 31

EP - 33

JO - Biotechnology Letters

JF - Biotechnology Letters

IS - 1

ER -

Extracts of Phellinus gilvus and Phellinus baumii inhibit pulmonary inflammation induced by lipopolysaccharide in rats

Abstract

Keywords

UN SDGs

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