Fabrication and In Vitro Biocompatibility Evaluation of Zr48Cu36Al9Ag7 Amorphous Alloy Scalpel

K. P. Shinde, P. K. Chaturvedi, J. S. Oh, J. N. Park, K. Choi, D. Shin, J. Oh, S. Yi, K. Ku, S. Lee, C. H. Chung, Woo Yoon Park, Joon Sik Park

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Zirconium based amorphous alloys are suitable for biomedical applications because of their excellent corrosion resistance and biocompatibility. In this study, Zr48Cu36Al9Ag7 amorphous alloy was fabricated by arc melting and ingot converted into the plate-shaped amorphous alloy by the suction method in a water cooled copper mold. Scalpels of the amorphous alloy were fabricated by using the polishing method. The X-ray diffraction and differential scanning calorimetry confirmed the amorphous nature of the Zr48Cu36Al9Ag7 alloy. Elemental confirmation of the amorphous alloy was confirmed with X-ray photoelectron spectroscopy analysis. The hardness of amorphous alloy was compared with a commercial stainless steel scalpel. The observed corrosion potentials of the stainless steel scalpel and Zr48Cu36Al9Ag7 amorphous scalpel were − 0.6 V and − 0.4 V, respectively which confirms that the corrosion resistance of the amorphous alloy is better than stainless steel. The biomedical application of the Zr48Cu36Al9Ag7 amorphous alloy scalpel is supported by a comparative study that examined in vitro cytotoxicity, cell viability, and wound healing tests and compared it with the standard stainless steel scalpel. Graphical Abstract: (Figure presented.)

Original languageEnglish
Pages (from-to)1794-1804
Number of pages11
JournalMetals and Materials International
Volume30
Issue number7
DOIs
StatePublished - Jul 2024

Keywords

  • Amorphous alloy
  • Biomedical application
  • Corrosion resistance
  • Cytotoxicity
  • Scalpel

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