Fabrication of alginate fiber using microfluidic device and cell encapsulation

Su Jung Shin, Kwang Ho Lee, Jin Young Lee, Sang Hoon Lee

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In this paper, we demonstrate a new continuous production technique of calcium alginate fibers with the microfluidic platform similar to spider. We have used the poly(dimethylsiloxane) (PDMS) microfluidic device embedded capillary glass pipette as apparatus for fiber generation. As a sample flow, we employed a 2%(w/w) sodium alginate solution and as a sheath flow, a 784mM CaCl2 solution was employed. We evaluated the potential use of alginate fibers as cell carrier by loading human fibroblasts during the 'on the fly' fabrication process. In addition, we evaluate the capability of loading the therapeutic materials onto the alginate fibers by immobilized BSA-FITC in the fibers.

Original languageEnglish
Title of host publicationProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
EditorsJean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin
PublisherChemical and Biological Microsystems Society
Pages961-963
Number of pages3
ISBN (Electronic)9780979806407
StatePublished - 2007
Event11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France
Duration: 7 Oct 200711 Oct 2007

Publication series

NameProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

Conference

Conference11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
Country/TerritoryFrance
CityParis
Period7/10/0711/10/07

Keywords

  • Alginate fiber
  • Encapsulation
  • Microfluidic
  • Tissue engineering

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