Facile preparation of a hybrid nanoprobe for triple-modality optical/PET/MR imaging

Jeong Chan Park; Mi Kyung Yu; Gwang Il An; Se Il Park; Jungmin Oh; Hong Joo Kim; Joo Hyun Kim; Eun Kyung Wang; Il Hwa Hong; Yeong Su Ha; Tae Hyun Choi; Kyu Shik Jeong; Yongmin Chang; Michael J. Welch; Sangyong Jon; Jeongsoo Yoo

doi:10.1002/smll.201001418

Facile preparation of a hybrid nanoprobe for triple-modality optical/PET/MR imaging

Jeong Chan Park, Mi Kyung Yu, Gwang Il An, Se Il Park, Jungmin Oh, Hong Joo Kim, Joo Hyun Kim, Eun Kyung Wang, Il Hwa Hong, Yeong Su Ha, Tae Hyun Choi, Kyu Shik Jeong, Yongmin Chang, Michael J. Welch, Sangyong Jon, Jeongsoo Yoo

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

A facile method of preparing triple-modality, optical-nuclear-magnetic imaging probes using radiolabeled superparamagnetic nanoparticles is developed. Cerenkov luminescence imaging based on radionuclides showed great potential as a new optical imaging modality. The complementary nature of the optical/PET/MR hybrid nanoprobes facilitated non-invasive differentiation between tumor-metastasized sentinel lymph nodes (SLNs) and tumor-free SLNs.

Original language	English
Pages (from-to)	2863-2868
Number of pages	6
Journal	Small
Volume	6
Issue number	24
DOIs	https://doi.org/10.1002/smll.201001418
State	Published - 20 Dec 2010

Keywords

hybrid materials
imaging agents
multimodality imaging
nanoparticles

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10.1002/smll.201001418

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abstract = "A facile method of preparing triple-modality, optical-nuclear-magnetic imaging probes using radiolabeled superparamagnetic nanoparticles is developed. Cerenkov luminescence imaging based on radionuclides showed great potential as a new optical imaging modality. The complementary nature of the optical/PET/MR hybrid nanoprobes facilitated non-invasive differentiation between tumor-metastasized sentinel lymph nodes (SLNs) and tumor-free SLNs.",

keywords = "hybrid materials, imaging agents, multimodality imaging, nanoparticles",

author = "Park, {Jeong Chan} and Yu, {Mi Kyung} and An, {Gwang Il} and Park, {Se Il} and Jungmin Oh and Kim, {Hong Joo} and Kim, {Joo Hyun} and Wang, {Eun Kyung} and Hong, {Il Hwa} and Ha, {Yeong Su} and Choi, {Tae Hyun} and Jeong, {Kyu Shik} and Yongmin Chang and Welch, {Michael J.} and Sangyong Jon and Jeongsoo Yoo",

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doi = "10.1002/smll.201001418",

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AU - Park, Jeong Chan

AU - Yu, Mi Kyung

AU - An, Gwang Il

AU - Park, Se Il

AU - Oh, Jungmin

AU - Kim, Hong Joo

AU - Kim, Joo Hyun

AU - Wang, Eun Kyung

AU - Hong, Il Hwa

AU - Ha, Yeong Su

AU - Choi, Tae Hyun

AU - Jeong, Kyu Shik

AU - Chang, Yongmin

AU - Welch, Michael J.

AU - Jon, Sangyong

AU - Yoo, Jeongsoo

PY - 2010/12/20

Y1 - 2010/12/20

N2 - A facile method of preparing triple-modality, optical-nuclear-magnetic imaging probes using radiolabeled superparamagnetic nanoparticles is developed. Cerenkov luminescence imaging based on radionuclides showed great potential as a new optical imaging modality. The complementary nature of the optical/PET/MR hybrid nanoprobes facilitated non-invasive differentiation between tumor-metastasized sentinel lymph nodes (SLNs) and tumor-free SLNs.

AB - A facile method of preparing triple-modality, optical-nuclear-magnetic imaging probes using radiolabeled superparamagnetic nanoparticles is developed. Cerenkov luminescence imaging based on radionuclides showed great potential as a new optical imaging modality. The complementary nature of the optical/PET/MR hybrid nanoprobes facilitated non-invasive differentiation between tumor-metastasized sentinel lymph nodes (SLNs) and tumor-free SLNs.

KW - hybrid materials

KW - imaging agents

KW - multimodality imaging

KW - nanoparticles

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ER -

Facile preparation of a hybrid nanoprobe for triple-modality optical/PET/MR imaging

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Keywords

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