Facile Synthesis and X-ray Attenuation Properties of Ultrasmall Platinum Nanoparticles Grafted with Three Types of Hydrophilic Polymers

Abdullah Khamis Ali Al Saidi; Adibehalsadat Ghazanfari; Shuwen Liu; Tirusew Tegafaw; Mohammad Yaseen Ahmad; Dejun Zhao; Ying Liu; So Hyeon Yang; Dong Wook Hwang; Ji Ung Yang; Ji Ae Park; Jae Chang Jung; Sung Wook Nam; Yongmin Chang; Gang Ho Lee

doi:10.3390/nano13050806

Facile Synthesis and X-ray Attenuation Properties of Ultrasmall Platinum Nanoparticles Grafted with Three Types of Hydrophilic Polymers

Abdullah Khamis Ali Al Saidi, Adibehalsadat Ghazanfari, Shuwen Liu, Tirusew Tegafaw, Mohammad Yaseen Ahmad, Dejun Zhao, Ying Liu, So Hyeon Yang, Dong Wook Hwang, Ji Ung Yang, Ji Ae Park, Jae Chang Jung, Sung Wook Nam, Yongmin Chang, Gang Ho Lee

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Abstract

Ultrasmall platinum nanoparticles (Pt-NPs) grafted with three types of hydrophilic and biocompatible polymers, i.e., poly(acrylic acid), poly(acrylic acid-co-maleic acid), and poly(methyl vinyl ether-alt-maleic acid) were synthesized using a one-pot polyol method. Their physicochemical and X-ray attenuation properties were characterized. All polymer-coated Pt-NPs had an average particle diameter (d_avg) of 2.0 nm. Polymers grafted onto Pt-NP surfaces exhibited excellent colloidal stability (i.e., no precipitation after synthesis for >1.5 years) and low cellular toxicity. The X-ray attenuation power of the polymer-coated Pt-NPs in aqueous media was stronger than that of the commercial iodine contrast agent Ultravist at the same atomic concentration and considerably stronger at the same number density, confirming their potential as computed tomography contrast agents.

Original language	English
Article number	806
Journal	Nanomaterials
Volume	13
Issue number	5
DOIs	https://doi.org/10.3390/nano13050806
State	Published - Mar 2023

Keywords

computed tomography contrast agent
high X-ray attenuation power
hydrophilic and biocompatible polymer coating
ultrasmall Pt nanoparticle

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10.3390/nano13050806

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Saidi, A. K. A. A., Ghazanfari, A., Liu, S., Tegafaw, T., Ahmad, M. Y., Zhao, D., Liu, Y., Yang, S. H., Hwang, D. W., Yang, J. U., Park, J. A., Jung, J. C., Nam, S. W., Chang, Y., & Lee, G. H. (2023). Facile Synthesis and X-ray Attenuation Properties of Ultrasmall Platinum Nanoparticles Grafted with Three Types of Hydrophilic Polymers. Nanomaterials, 13(5), Article 806. https://doi.org/10.3390/nano13050806

@article{145cd69e98be43e782fc5eb2e8766e57,

title = "Facile Synthesis and X-ray Attenuation Properties of Ultrasmall Platinum Nanoparticles Grafted with Three Types of Hydrophilic Polymers",

abstract = "Ultrasmall platinum nanoparticles (Pt-NPs) grafted with three types of hydrophilic and biocompatible polymers, i.e., poly(acrylic acid), poly(acrylic acid-co-maleic acid), and poly(methyl vinyl ether-alt-maleic acid) were synthesized using a one-pot polyol method. Their physicochemical and X-ray attenuation properties were characterized. All polymer-coated Pt-NPs had an average particle diameter (davg) of 2.0 nm. Polymers grafted onto Pt-NP surfaces exhibited excellent colloidal stability (i.e., no precipitation after synthesis for >1.5 years) and low cellular toxicity. The X-ray attenuation power of the polymer-coated Pt-NPs in aqueous media was stronger than that of the commercial iodine contrast agent Ultravist at the same atomic concentration and considerably stronger at the same number density, confirming their potential as computed tomography contrast agents.",

keywords = "computed tomography contrast agent, high X-ray attenuation power, hydrophilic and biocompatible polymer coating, ultrasmall Pt nanoparticle",

author = "Saidi, {Abdullah Khamis Ali Al} and Adibehalsadat Ghazanfari and Shuwen Liu and Tirusew Tegafaw and Ahmad, {Mohammad Yaseen} and Dejun Zhao and Ying Liu and Yang, {So Hyeon} and Hwang, {Dong Wook} and Yang, {Ji Ung} and Park, {Ji Ae} and Jung, {Jae Chang} and Nam, {Sung Wook} and Yongmin Chang and Lee, {Gang Ho}",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = mar,

doi = "10.3390/nano13050806",

language = "English",

volume = "13",

journal = "Nanomaterials",

issn = "2079-4991",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "5",

}

Saidi, AKAA, Ghazanfari, A, Liu, S, Tegafaw, T, Ahmad, MY, Zhao, D, Liu, Y, Yang, SH, Hwang, DW, Yang, JU, Park, JA, Jung, JC , Nam, SW , Chang, Y & Lee, GH 2023, 'Facile Synthesis and X-ray Attenuation Properties of Ultrasmall Platinum Nanoparticles Grafted with Three Types of Hydrophilic Polymers', Nanomaterials, vol. 13, no. 5, 806. https://doi.org/10.3390/nano13050806

TY - JOUR

T1 - Facile Synthesis and X-ray Attenuation Properties of Ultrasmall Platinum Nanoparticles Grafted with Three Types of Hydrophilic Polymers

AU - Saidi, Abdullah Khamis Ali Al

AU - Ghazanfari, Adibehalsadat

AU - Liu, Shuwen

AU - Tegafaw, Tirusew

AU - Ahmad, Mohammad Yaseen

AU - Zhao, Dejun

AU - Liu, Ying

AU - Yang, So Hyeon

AU - Hwang, Dong Wook

AU - Yang, Ji Ung

AU - Park, Ji Ae

AU - Jung, Jae Chang

AU - Nam, Sung Wook

AU - Chang, Yongmin

AU - Lee, Gang Ho

PY - 2023/3

Y1 - 2023/3

N2 - Ultrasmall platinum nanoparticles (Pt-NPs) grafted with three types of hydrophilic and biocompatible polymers, i.e., poly(acrylic acid), poly(acrylic acid-co-maleic acid), and poly(methyl vinyl ether-alt-maleic acid) were synthesized using a one-pot polyol method. Their physicochemical and X-ray attenuation properties were characterized. All polymer-coated Pt-NPs had an average particle diameter (davg) of 2.0 nm. Polymers grafted onto Pt-NP surfaces exhibited excellent colloidal stability (i.e., no precipitation after synthesis for >1.5 years) and low cellular toxicity. The X-ray attenuation power of the polymer-coated Pt-NPs in aqueous media was stronger than that of the commercial iodine contrast agent Ultravist at the same atomic concentration and considerably stronger at the same number density, confirming their potential as computed tomography contrast agents.

AB - Ultrasmall platinum nanoparticles (Pt-NPs) grafted with three types of hydrophilic and biocompatible polymers, i.e., poly(acrylic acid), poly(acrylic acid-co-maleic acid), and poly(methyl vinyl ether-alt-maleic acid) were synthesized using a one-pot polyol method. Their physicochemical and X-ray attenuation properties were characterized. All polymer-coated Pt-NPs had an average particle diameter (davg) of 2.0 nm. Polymers grafted onto Pt-NP surfaces exhibited excellent colloidal stability (i.e., no precipitation after synthesis for >1.5 years) and low cellular toxicity. The X-ray attenuation power of the polymer-coated Pt-NPs in aqueous media was stronger than that of the commercial iodine contrast agent Ultravist at the same atomic concentration and considerably stronger at the same number density, confirming their potential as computed tomography contrast agents.

KW - computed tomography contrast agent

KW - high X-ray attenuation power

KW - hydrophilic and biocompatible polymer coating

KW - ultrasmall Pt nanoparticle

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U2 - 10.3390/nano13050806

DO - 10.3390/nano13050806

M3 - Article

AN - SCOPUS:85149746916

SN - 2079-4991

VL - 13

JO - Nanomaterials

JF - Nanomaterials

IS - 5

M1 - 806

ER -

Facile Synthesis and X-ray Attenuation Properties of Ultrasmall Platinum Nanoparticles Grafted with Three Types of Hydrophilic Polymers

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Keywords

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