Five new diterpenoids from the barks of Cinnamomum cassia (L.) J. Presl

Van Cong Pham; Thi Thuy An Nguyen; Thi Oanh Vu; Thao Quyen Cao; Byung Sun Min; Jeong Ah Kim

doi:10.1016/j.phytol.2019.04.025

Five new diterpenoids from the barks of Cinnamomum cassia (L.) J. Presl

Van Cong Pham, Thi Thuy An Nguyen, Thi Oanh Vu, Thao Quyen Cao, Byung Sun Min, Jeong Ah Kim

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Here, we report the isolation of five new diterpenoids including four lactone-type diterpenes (3, 5-7) and a hemiketal-type diterpene (12) in addition to 10 known compounds from the bark of Cinnamomum cassia (L.) J. Presl. Molecular structures were elucidated by various spectroscopic methods including 1- and 2-dimensional NMR, high-resolution MS, and circular dichroism. No cytotoxic activity was observed for any of the isolated compounds (1-15) as examined in vitro in three cancer cell lines (HeLa, HL-60, and MCF-7) using the MTT assay.

Original language	English
Pages (from-to)	23-28
Number of pages	6
Journal	Phytochemistry Letters
Volume	32
DOIs	https://doi.org/10.1016/j.phytol.2019.04.025
State	Published - Aug 2019

Keywords

Cinnamomum cassia
Cytotoxicity
Diterpenoids
Lauraceae

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytol.2019.04.025

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title = "Five new diterpenoids from the barks of Cinnamomum cassia (L.) J. Presl",

abstract = "Here, we report the isolation of five new diterpenoids including four lactone-type diterpenes (3, 5-7) and a hemiketal-type diterpene (12) in addition to 10 known compounds from the bark of Cinnamomum cassia (L.) J. Presl. Molecular structures were elucidated by various spectroscopic methods including 1- and 2-dimensional NMR, high-resolution MS, and circular dichroism. No cytotoxic activity was observed for any of the isolated compounds (1-15) as examined in vitro in three cancer cell lines (HeLa, HL-60, and MCF-7) using the MTT assay.",

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author = "Pham, \{Van Cong\} and Nguyen, \{Thi Thuy An\} and Vu, \{Thi Oanh\} and Cao, \{Thao Quyen\} and Min, \{Byung Sun\} and Kim, \{Jeong Ah\}",

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year = "2019",

month = aug,

doi = "10.1016/j.phytol.2019.04.025",

language = "English",

volume = "32",

pages = "23--28",

journal = "Phytochemistry Letters",

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TY - JOUR

T1 - Five new diterpenoids from the barks of Cinnamomum cassia (L.) J. Presl

AU - Pham, Van Cong

AU - Nguyen, Thi Thuy An

AU - Vu, Thi Oanh

AU - Cao, Thao Quyen

AU - Min, Byung Sun

AU - Kim, Jeong Ah

PY - 2019/8

Y1 - 2019/8

N2 - Here, we report the isolation of five new diterpenoids including four lactone-type diterpenes (3, 5-7) and a hemiketal-type diterpene (12) in addition to 10 known compounds from the bark of Cinnamomum cassia (L.) J. Presl. Molecular structures were elucidated by various spectroscopic methods including 1- and 2-dimensional NMR, high-resolution MS, and circular dichroism. No cytotoxic activity was observed for any of the isolated compounds (1-15) as examined in vitro in three cancer cell lines (HeLa, HL-60, and MCF-7) using the MTT assay.

AB - Here, we report the isolation of five new diterpenoids including four lactone-type diterpenes (3, 5-7) and a hemiketal-type diterpene (12) in addition to 10 known compounds from the bark of Cinnamomum cassia (L.) J. Presl. Molecular structures were elucidated by various spectroscopic methods including 1- and 2-dimensional NMR, high-resolution MS, and circular dichroism. No cytotoxic activity was observed for any of the isolated compounds (1-15) as examined in vitro in three cancer cell lines (HeLa, HL-60, and MCF-7) using the MTT assay.

KW - Cinnamomum cassia

KW - Cytotoxicity

KW - Diterpenoids

KW - Lauraceae

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DO - 10.1016/j.phytol.2019.04.025

M3 - Article

AN - SCOPUS:85065031446

SN - 1874-3900

VL - 32

SP - 23

EP - 28

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Five new diterpenoids from the barks of Cinnamomum cassia (L.) J. Presl

Abstract

Keywords

UN SDGs

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