Five new diterpenoids from the barks of Cinnamomum cassia (L.) J. Presl

Van Cong Pham; Thi Thuy An Nguyen; Thi Oanh Vu; Thao Quyen Cao; Byung Sun Min; Jeong Ah Kim

doi:10.1016/j.phytol.2019.04.025

Five new diterpenoids from the barks of Cinnamomum cassia (L.) J. Presl

Van Cong Pham
, Thi Thuy An Nguyen
, Thi Oanh Vu
, Thao Quyen Cao
, Byung Sun Min
, Jeong Ah Kim

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Here, we report the isolation of five new diterpenoids including four lactone-type diterpenes (3, 5-7) and a hemiketal-type diterpene (12) in addition to 10 known compounds from the bark of Cinnamomum cassia (L.) J. Presl. Molecular structures were elucidated by various spectroscopic methods including 1- and 2-dimensional NMR, high-resolution MS, and circular dichroism. No cytotoxic activity was observed for any of the isolated compounds (1-15) as examined in vitro in three cancer cell lines (HeLa, HL-60, and MCF-7) using the MTT assay.

Original language	English
Pages (from-to)	23-28
Number of pages	6
Journal	Phytochemistry Letters
Volume	32
DOIs	https://doi.org/10.1016/j.phytol.2019.04.025
State	Published - Aug 2019

Keywords

Cinnamomum cassia
Cytotoxicity
Diterpenoids
Lauraceae

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytol.2019.04.025

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title = "Five new diterpenoids from the barks of Cinnamomum cassia (L.) J. Presl",

abstract = "Here, we report the isolation of five new diterpenoids including four lactone-type diterpenes (3, 5-7) and a hemiketal-type diterpene (12) in addition to 10 known compounds from the bark of Cinnamomum cassia (L.) J. Presl. Molecular structures were elucidated by various spectroscopic methods including 1- and 2-dimensional NMR, high-resolution MS, and circular dichroism. No cytotoxic activity was observed for any of the isolated compounds (1-15) as examined in vitro in three cancer cell lines (HeLa, HL-60, and MCF-7) using the MTT assay.",

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author = "Pham, \{Van Cong\} and Nguyen, \{Thi Thuy An\} and Vu, \{Thi Oanh\} and Cao, \{Thao Quyen\} and Min, \{Byung Sun\} and Kim, \{Jeong Ah\}",

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year = "2019",

month = aug,

doi = "10.1016/j.phytol.2019.04.025",

language = "English",

volume = "32",

pages = "23--28",

journal = "Phytochemistry Letters",

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TY - JOUR

T1 - Five new diterpenoids from the barks of Cinnamomum cassia (L.) J. Presl

AU - Pham, Van Cong

AU - Nguyen, Thi Thuy An

AU - Vu, Thi Oanh

AU - Cao, Thao Quyen

AU - Min, Byung Sun

AU - Kim, Jeong Ah

PY - 2019/8

Y1 - 2019/8

N2 - Here, we report the isolation of five new diterpenoids including four lactone-type diterpenes (3, 5-7) and a hemiketal-type diterpene (12) in addition to 10 known compounds from the bark of Cinnamomum cassia (L.) J. Presl. Molecular structures were elucidated by various spectroscopic methods including 1- and 2-dimensional NMR, high-resolution MS, and circular dichroism. No cytotoxic activity was observed for any of the isolated compounds (1-15) as examined in vitro in three cancer cell lines (HeLa, HL-60, and MCF-7) using the MTT assay.

AB - Here, we report the isolation of five new diterpenoids including four lactone-type diterpenes (3, 5-7) and a hemiketal-type diterpene (12) in addition to 10 known compounds from the bark of Cinnamomum cassia (L.) J. Presl. Molecular structures were elucidated by various spectroscopic methods including 1- and 2-dimensional NMR, high-resolution MS, and circular dichroism. No cytotoxic activity was observed for any of the isolated compounds (1-15) as examined in vitro in three cancer cell lines (HeLa, HL-60, and MCF-7) using the MTT assay.

KW - Cinnamomum cassia

KW - Cytotoxicity

KW - Diterpenoids

KW - Lauraceae

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DO - 10.1016/j.phytol.2019.04.025

M3 - Article

AN - SCOPUS:85065031446

SN - 1874-3900

VL - 32

SP - 23

EP - 28

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Five new diterpenoids from the barks of Cinnamomum cassia (L.) J. Presl

Abstract

Keywords

UN SDGs

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