Flavonoid glycosides from the fruit of Rhus parviflora and inhibition of cyclin dependent kinases by hyperin

Sabina Shrestha; Dae Young Lee; Ji Hae Park; Jin Gyeong Cho; Woo Duck Seo; Hee Cheol Kang; Yong Jin Jeon; Seung Woo Yeon; Myun Ho Bang; Nam In Baek

doi:10.1007/s13765-012-2133-2

Flavonoid glycosides from the fruit of Rhus parviflora and inhibition of cyclin dependent kinases by hyperin

Sabina Shrestha, Dae Young Lee, Ji Hae Park, Jin Gyeong Cho, Woo Duck Seo, Hee Cheol Kang, Yong Jin Jeon, Seung Woo Yeon, Myun Ho Bang, Nam In Baek

School of Life Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Chrysoeriol-7-O-β-d-glucopyranoside (1), luteolin-7-O-β-d-glucopyranoside (2), quercetin-3-O-β-d-glucopyranoside (3), quercetin-3-O-β-d-galactopyranoside (4), and quercetin-3-O-α-l-rhamnopyranoside (5) were isolated for the first time from the fruits of Rhus parviflora. The chemical structures of the compounds were determined using nuclear magnetic resonance, fast atom bombardment mass spectrometry, and infrared spectroscopy. Compound 4 (hyperin) inhibited cyclin dependent kinases (CDK2 and CDK5) in vitro with IC₅₀ values of 21.02 and 10.28 μM, respectively.

Original language	English
Pages (from-to)	689-693
Number of pages	5
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume	55
Issue number	5
DOIs	https://doi.org/10.1007/s13765-012-2133-2
State	Published - Oct 2012

Keywords

CDK 5
cyclin-dependent kinase (CDK) 2
hyperin
isoquercetin
luteoloside
quercetrin
Rhus parviflora
thermopsoside

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10.1007/s13765-012-2133-2

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title = "Flavonoid glycosides from the fruit of Rhus parviflora and inhibition of cyclin dependent kinases by hyperin",

abstract = "Chrysoeriol-7-O-β-d-glucopyranoside (1), luteolin-7-O-β-d-glucopyranoside (2), quercetin-3-O-β-d-glucopyranoside (3), quercetin-3-O-β-d-galactopyranoside (4), and quercetin-3-O-α-l-rhamnopyranoside (5) were isolated for the first time from the fruits of Rhus parviflora. The chemical structures of the compounds were determined using nuclear magnetic resonance, fast atom bombardment mass spectrometry, and infrared spectroscopy. Compound 4 (hyperin) inhibited cyclin dependent kinases (CDK2 and CDK5) in vitro with IC50 values of 21.02 and 10.28 μM, respectively.",

keywords = "CDK 5, cyclin-dependent kinase (CDK) 2, hyperin, isoquercetin, luteoloside, quercetrin, Rhus parviflora, thermopsoside",

author = "Sabina Shrestha and Lee, {Dae Young} and Park, {Ji Hae} and Cho, {Jin Gyeong} and Seo, {Woo Duck} and Kang, {Hee Cheol} and Jeon, {Yong Jin} and Yeon, {Seung Woo} and Bang, {Myun Ho} and Baek, {Nam In}",

year = "2012",

month = oct,

doi = "10.1007/s13765-012-2133-2",

language = "English",

volume = "55",

pages = "689--693",

journal = "Journal of the Korean Society for Applied Biological Chemistry",

issn = "1738-2203",

publisher = "Springer Nature",

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TY - JOUR

T1 - Flavonoid glycosides from the fruit of Rhus parviflora and inhibition of cyclin dependent kinases by hyperin

AU - Shrestha, Sabina

AU - Lee, Dae Young

AU - Park, Ji Hae

AU - Cho, Jin Gyeong

AU - Seo, Woo Duck

AU - Kang, Hee Cheol

AU - Jeon, Yong Jin

AU - Yeon, Seung Woo

AU - Bang, Myun Ho

AU - Baek, Nam In

PY - 2012/10

Y1 - 2012/10

N2 - Chrysoeriol-7-O-β-d-glucopyranoside (1), luteolin-7-O-β-d-glucopyranoside (2), quercetin-3-O-β-d-glucopyranoside (3), quercetin-3-O-β-d-galactopyranoside (4), and quercetin-3-O-α-l-rhamnopyranoside (5) were isolated for the first time from the fruits of Rhus parviflora. The chemical structures of the compounds were determined using nuclear magnetic resonance, fast atom bombardment mass spectrometry, and infrared spectroscopy. Compound 4 (hyperin) inhibited cyclin dependent kinases (CDK2 and CDK5) in vitro with IC50 values of 21.02 and 10.28 μM, respectively.

AB - Chrysoeriol-7-O-β-d-glucopyranoside (1), luteolin-7-O-β-d-glucopyranoside (2), quercetin-3-O-β-d-glucopyranoside (3), quercetin-3-O-β-d-galactopyranoside (4), and quercetin-3-O-α-l-rhamnopyranoside (5) were isolated for the first time from the fruits of Rhus parviflora. The chemical structures of the compounds were determined using nuclear magnetic resonance, fast atom bombardment mass spectrometry, and infrared spectroscopy. Compound 4 (hyperin) inhibited cyclin dependent kinases (CDK2 and CDK5) in vitro with IC50 values of 21.02 and 10.28 μM, respectively.

KW - CDK 5

KW - cyclin-dependent kinase (CDK) 2

KW - hyperin

KW - isoquercetin

KW - luteoloside

KW - quercetrin

KW - Rhus parviflora

KW - thermopsoside

UR - http://www.scopus.com/inward/record.url?scp=84868327015&partnerID=8YFLogxK

U2 - 10.1007/s13765-012-2133-2

DO - 10.1007/s13765-012-2133-2

M3 - Article

AN - SCOPUS:84868327015

SN - 1738-2203

VL - 55

SP - 689

EP - 693

JO - Journal of the Korean Society for Applied Biological Chemistry

JF - Journal of the Korean Society for Applied Biological Chemistry

IS - 5

ER -

Flavonoid glycosides from the fruit of Rhus parviflora and inhibition of cyclin dependent kinases by hyperin

Abstract

Keywords

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