Flavonoids from silkworm droppings and their promotional activities on heme oxygenase-1

Ji Hae Park, Dae Young Lee, Pyeong Yun, Seung Woo Yeon, Jong Hee Ko, Yong Soon Kim, Nam In Baek

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A new flavane glucoside, 7,2'-dihydroxy-8-hydroxyethyl-4'-methoxyflavane- 2'-O-β-d-glucopyranoside (3), along with three known flavonoids, 7,2'-dihydroxy-8-prenyl-4'-methoxyflavane (1), euchrenone a7 (2), and 7,2'-dihydroxy-8-prenyl-4'-methoxy-2'-O-β-d-glucopyranosylflavane (4), was isolated from silkworm droppings. The structures of the compounds were elucidated on the basis of 1D and 2D NMR spectroscopic analyses and optical rotational characteristics. The compounds isolated from silkworm droppings were evaluated for their effects on heme oxygenase-1 (HO-1) activity. Compounds 1 and 3 increased the expression of HO-1 in HepG2 cells. HO-1 is an antioxidant enzyme that catabolizes heme to carbon monoxide, free iron, and biliverdin, all of which are involved in the suppression of inflammatory mediators.

Original languageEnglish
Pages (from-to)377-382
Number of pages6
JournalJournal of Asian Natural Products Research
Volume13
Issue number4
DOIs
StatePublished - Apr 2011

Keywords

  • 7,2'-dihydroxy-8-hydroxyethyl-4'-methoxyflavane-2'-O-β-d- glucopyranoside
  • Bombyx mori
  • HO-1
  • silkworm droppings

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