TY - JOUR
T1 - Flavonoids from the buds of rosa damascena inhibit the activity of 3-Hydroxy-3-methylglutaryl-coenzyme a reductase and angiotensin I-converting enzyme
AU - Kwon, Eun Kyung
AU - Lee, Dae Young
AU - Hyungjae, Lee
AU - Kim, Dae O.K.
AU - Baek, Nam I.N.
AU - Kim, Young Eon
AU - Kim, Hae Yeong
PY - 2010/1/27
Y1 - 2010/1/27
N2 - Rosa damascena has been manufactured as various food products, including tea, in Korea. A new flavonoid glycoside, kaempferol-3-O-β-D- glucopyranosyl(1-→4)-β-D-xylopyranoside, named roxyloside A was isolated from the buds of this plant, along with four known compounds, isoquercitrin, afzelin, cyanidin-3-O-β-glucoside, and quercetin gentiobioside. The chemical structures of these compounds were determined by spectroscopic analyses, including FAB-MS, UV, IR, 1H and 13C NMR, DEPT, and 2D NMR (COSY, HSQC, and HMBC). All the isolated compounds except cyanidin-3-O-β-glucoside exhibited high levels of inhibitory activity against 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase with IC50 values ranging from 47.1 to 80.6 μM. Cyanidin-3-O-β-glucoside significantly suppressed angiotensin I-converting enzyme (ACE) activity, with an IC50 value of 138.8 μM, while the other four compounds were ineffective. These results indicate that R. damascena and its flavonoids may be effective to improve the cardiovascular system.
AB - Rosa damascena has been manufactured as various food products, including tea, in Korea. A new flavonoid glycoside, kaempferol-3-O-β-D- glucopyranosyl(1-→4)-β-D-xylopyranoside, named roxyloside A was isolated from the buds of this plant, along with four known compounds, isoquercitrin, afzelin, cyanidin-3-O-β-glucoside, and quercetin gentiobioside. The chemical structures of these compounds were determined by spectroscopic analyses, including FAB-MS, UV, IR, 1H and 13C NMR, DEPT, and 2D NMR (COSY, HSQC, and HMBC). All the isolated compounds except cyanidin-3-O-β-glucoside exhibited high levels of inhibitory activity against 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase with IC50 values ranging from 47.1 to 80.6 μM. Cyanidin-3-O-β-glucoside significantly suppressed angiotensin I-converting enzyme (ACE) activity, with an IC50 value of 138.8 μM, while the other four compounds were ineffective. These results indicate that R. damascena and its flavonoids may be effective to improve the cardiovascular system.
KW - Angiotensin i-converting enzyme
KW - Cardiovascular system
KW - Flavonoids
KW - Hmg-coa reductase
KW - Rosa damascene
KW - Roxyloside a
UR - http://www.scopus.com/inward/record.url?scp=74849124070&partnerID=8YFLogxK
U2 - 10.1021/jf903515f
DO - 10.1021/jf903515f
M3 - Article
C2 - 20038104
AN - SCOPUS:74849124070
SN - 0021-8561
VL - 58
SP - 882
EP - 886
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
IS - 2
ER -