Abstract
The aim of this study was to qualitatively determine the effect of fluoride (F) on the intake and distribution of aluminum (Al) into tissues of rats. Twenty-eight Sprague-Dawley rats were randomly divided into four groups, and fed with 0, 1, 20, or 100 ppm sodium fluoride (NaF). All rats were intraperitoneally (ip) injected with 0.69 mg Al once a week for 24 weeks. Femurs, kidneys, liver, and brain were removed. The F and Al were analyzed using a specific F ion electrode and an inductively coupled plasma atomic emission spectrophotometer, respectively. Tissues were stained with solochrome azurine and examined by light microscopy. The body burden of Al decreased following administration of F, and a significant difference was observed in the liver. The qualitative analysis of Al showed that Al grains in the group administered Al alone were present either in the cytoplasm of liver cells or around the hepatic artery and portal vein or macrophage-like cells, but the number of Al deposits was markedly reduced in 100 ppm NaF group. It is postulated that F forms an inactive complex with Al, thus reducing the body burden of Al in rats.
| Original language | English |
|---|---|
| Pages (from-to) | 1149-1156 |
| Number of pages | 8 |
| Journal | Toxicological and Environmental Chemistry |
| Volume | 92 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jul 2010 |
Keywords
- Aluminum
- Deposition
- Fluoride