Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis

Alain S. Leutou; Inho Yang; Tu Cam Le; Dongyup Hahn; Kyung Min Lim; Sang Jip Nam; William Fenical

doi:10.1038/s41429-018-0033-3

Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis

Alain S. Leutou
, Inho Yang
, Tu Cam Le
, Dongyup Hahn
, Kyung Min Lim
, Sang Jip Nam
, William Fenical

School of Food Science & Biotechnology

Ewha Womans University
University of California at San Diego

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.

Original language	English
Pages (from-to)	609-612
Number of pages	4
Journal	Journal of Antibiotics
Volume	71
Issue number	6
DOIs	https://doi.org/10.1038/s41429-018-0033-3
State	Published - 1 Jun 2018

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title = "Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis",

abstract = "A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.",

author = "Leutou, \{Alain S.\} and Inho Yang and Le, \{Tu Cam\} and Dongyup Hahn and Lim, \{Kyung Min\} and Nam, \{Sang Jip\} and William Fenical",

note = "Publisher Copyright: {\textcopyright} 2018 The Author(s) under exclusive licence to the Japan Antibiotics Research Association.",

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doi = "10.1038/s41429-018-0033-3",

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AU - Leutou, Alain S.

AU - Yang, Inho

AU - Le, Tu Cam

AU - Hahn, Dongyup

AU - Lim, Kyung Min

AU - Nam, Sang Jip

AU - Fenical, William

PY - 2018/6/1

Y1 - 2018/6/1

N2 - A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.

AB - A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.

UR - https://www.scopus.com/pages/publications/85042207485

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DO - 10.1038/s41429-018-0033-3

M3 - Article

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AN - SCOPUS:85042207485

SN - 0021-8820

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SP - 609

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JO - Journal of Antibiotics

JF - Journal of Antibiotics

IS - 6

ER -

Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis

Abstract

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