FoxP3, PD-1 and CTLA-4 are decreased significantly after a tenofovir therapy in patients with chronic hepatitis B

Hyosun Cho; Hyojeung Kang; Ji Y. Kim; Hee Y. Kim; Chang W. Kim

doi:10.2217/fvl-2019-0128

FoxP3, PD-1 and CTLA-4 are decreased significantly after a tenofovir therapy in patients with chronic hepatitis B

Hyosun Cho, Hyojeung Kang, Ji Y. Kim, Hee Y. Kim, Chang W. Kim

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: FoxP3, PD-1 and CTLA-4 are upregulated in chronic viral infections, such as chronic HCV, chronic HBV and HIV infection. Materials and methods: During 1 year of tenofovir disoproxil fumarate (TDF) treatment in patients with chronic hepatitis B, we investigated the expression of FoxP3, PD-1 and CTLA-4. Peripheral blood mononuclear cells were isolated from the 30 study subjects at T0 (0 months), T3, T6 and T12 months after the commencement of TDF treatment. Results and conclusion: Expression of FoxP3, PD-1 and CTLA-4 was significantly decreased in T cells of patients with chronic hepatitis B under TDF treatment at T12, when compared with that at T0. A direct correlation was observed between FoxP3 and CTLA-4 expression in patients with chronic hepatitis B and the frequency of FoxP3 was positively associated with serum alanine aminotransferase levels.

Original language	English
Pages (from-to)	237-246
Number of pages	10
Journal	Future Virology
Volume	15
Issue number	4
DOIs	https://doi.org/10.2217/fvl-2019-0128
State	Published - Apr 2020

Keywords

CTLA-4
FoxP3
HBV
PD-1
tenofovir

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/fvl-2019-0128

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@article{3ace2d08ddda4ff5ad330bb3f8992c42,

title = "FoxP3, PD-1 and CTLA-4 are decreased significantly after a tenofovir therapy in patients with chronic hepatitis B",

abstract = "Background: FoxP3, PD-1 and CTLA-4 are upregulated in chronic viral infections, such as chronic HCV, chronic HBV and HIV infection. Materials and methods: During 1 year of tenofovir disoproxil fumarate (TDF) treatment in patients with chronic hepatitis B, we investigated the expression of FoxP3, PD-1 and CTLA-4. Peripheral blood mononuclear cells were isolated from the 30 study subjects at T0 (0 months), T3, T6 and T12 months after the commencement of TDF treatment. Results and conclusion: Expression of FoxP3, PD-1 and CTLA-4 was significantly decreased in T cells of patients with chronic hepatitis B under TDF treatment at T12, when compared with that at T0. A direct correlation was observed between FoxP3 and CTLA-4 expression in patients with chronic hepatitis B and the frequency of FoxP3 was positively associated with serum alanine aminotransferase levels.",

keywords = "CTLA-4, FoxP3, HBV, PD-1, tenofovir",

author = "Hyosun Cho and Hyojeung Kang and Kim, {Ji Y.} and Kim, {Hee Y.} and Kim, {Chang W.}",

note = "Publisher Copyright: {\textcopyright} 2020 ",

year = "2020",

month = apr,

doi = "10.2217/fvl-2019-0128",

language = "English",

volume = "15",

pages = "237--246",

journal = "Future Virology",

issn = "1746-0794",

publisher = "Taylor and Francis Ltd.",

number = "4",

}

TY - JOUR

T1 - FoxP3, PD-1 and CTLA-4 are decreased significantly after a tenofovir therapy in patients with chronic hepatitis B

AU - Cho, Hyosun

AU - Kang, Hyojeung

AU - Kim, Ji Y.

AU - Kim, Hee Y.

AU - Kim, Chang W.

PY - 2020/4

Y1 - 2020/4

N2 - Background: FoxP3, PD-1 and CTLA-4 are upregulated in chronic viral infections, such as chronic HCV, chronic HBV and HIV infection. Materials and methods: During 1 year of tenofovir disoproxil fumarate (TDF) treatment in patients with chronic hepatitis B, we investigated the expression of FoxP3, PD-1 and CTLA-4. Peripheral blood mononuclear cells were isolated from the 30 study subjects at T0 (0 months), T3, T6 and T12 months after the commencement of TDF treatment. Results and conclusion: Expression of FoxP3, PD-1 and CTLA-4 was significantly decreased in T cells of patients with chronic hepatitis B under TDF treatment at T12, when compared with that at T0. A direct correlation was observed between FoxP3 and CTLA-4 expression in patients with chronic hepatitis B and the frequency of FoxP3 was positively associated with serum alanine aminotransferase levels.

AB - Background: FoxP3, PD-1 and CTLA-4 are upregulated in chronic viral infections, such as chronic HCV, chronic HBV and HIV infection. Materials and methods: During 1 year of tenofovir disoproxil fumarate (TDF) treatment in patients with chronic hepatitis B, we investigated the expression of FoxP3, PD-1 and CTLA-4. Peripheral blood mononuclear cells were isolated from the 30 study subjects at T0 (0 months), T3, T6 and T12 months after the commencement of TDF treatment. Results and conclusion: Expression of FoxP3, PD-1 and CTLA-4 was significantly decreased in T cells of patients with chronic hepatitis B under TDF treatment at T12, when compared with that at T0. A direct correlation was observed between FoxP3 and CTLA-4 expression in patients with chronic hepatitis B and the frequency of FoxP3 was positively associated with serum alanine aminotransferase levels.

KW - CTLA-4

KW - FoxP3

KW - HBV

KW - PD-1

KW - tenofovir

UR - http://www.scopus.com/inward/record.url?scp=85091116359&partnerID=8YFLogxK

U2 - 10.2217/fvl-2019-0128

DO - 10.2217/fvl-2019-0128

M3 - Article

AN - SCOPUS:85091116359

SN - 1746-0794

VL - 15

SP - 237

EP - 246

JO - Future Virology

JF - Future Virology

IS - 4

ER -

FoxP3, PD-1 and CTLA-4 are decreased significantly after a tenofovir therapy in patients with chronic hepatitis B

Abstract

Keywords

UN SDGs

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