TY - JOUR
T1 - From dusk till dawn
T2 - cell cycle progression in the red seaweed Gracilariopsis chorda (Rhodophyta)
AU - Lee, Jun Mo
AU - Miyagishima, Shin ya
AU - Bhattacharya, Debashish
AU - Yoon, Hwan Su
N1 - Publisher Copyright:
© 2024 The Author(s)
PY - 2024/7/19
Y1 - 2024/7/19
N2 - The conserved eukaryotic functions of cell cycle genes have primarily been studied using animal/plant models and unicellular algae. Cell cycle progression and its regulatory components in red (Rhodophyta) seaweeds are poorly understood. We analyzed diurnal gene expression data to investigate the cell cycle in the red seaweed Gracilariopsis chorda. We identified cell cycle progression and transitions in G. chorda which are induced by interactions of key regulators such as E2F/DP, RBR, cyclin-dependent kinases, and cyclins from dusk to dawn. However, several typical CDK inhibitor proteins are absent in red seaweeds. Interestingly, the G1-S transition in G. chorda is controlled by delayed transcription of GINS subunit 3. We propose that the delayed S phase entry in this seaweed may have evolved to minimize DNA damage (e.g., due to UV radiation) during replication. Our results provide important insights into cell cycle-associated physiology and its molecular mechanisms in red seaweeds.
AB - The conserved eukaryotic functions of cell cycle genes have primarily been studied using animal/plant models and unicellular algae. Cell cycle progression and its regulatory components in red (Rhodophyta) seaweeds are poorly understood. We analyzed diurnal gene expression data to investigate the cell cycle in the red seaweed Gracilariopsis chorda. We identified cell cycle progression and transitions in G. chorda which are induced by interactions of key regulators such as E2F/DP, RBR, cyclin-dependent kinases, and cyclins from dusk to dawn. However, several typical CDK inhibitor proteins are absent in red seaweeds. Interestingly, the G1-S transition in G. chorda is controlled by delayed transcription of GINS subunit 3. We propose that the delayed S phase entry in this seaweed may have evolved to minimize DNA damage (e.g., due to UV radiation) during replication. Our results provide important insights into cell cycle-associated physiology and its molecular mechanisms in red seaweeds.
KW - Botany
KW - Molecular biology
KW - Molecular physiology
UR - http://www.scopus.com/inward/record.url?scp=85196035692&partnerID=8YFLogxK
U2 - 10.1016/j.isci.2024.110190
DO - 10.1016/j.isci.2024.110190
M3 - Article
AN - SCOPUS:85196035692
SN - 2589-0042
VL - 27
JO - iScience
JF - iScience
IS - 7
M1 - 110190
ER -