Fucosterols from Hizikia fusiformis and their proliferation activities on osteosarcoma-derived cell MG63

Gyu Won Huh; Dae Young Lee; Suh Ji In; Don Gil Lee; Sang Yong Park; Tae Hoo Yi; Hee Cheol Kang; Woo Duck Seo; Nam In Baek

doi:10.1007/s13765-012-2069-6

Fucosterols from Hizikia fusiformis and their proliferation activities on osteosarcoma-derived cell MG63

Gyu Won Huh, Dae Young Lee, Suh Ji In, Don Gil Lee, Sang Yong Park, Tae Hoo Yi, Hee Cheol Kang, Woo Duck Seo, Nam In Baek

School of Life Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Four fucosterol derivatives were isolated from the ethyl acetate fraction of Hizikia fusiformis. The chemical structures of the sterols were elucidated as fucosterol (1), a mixture of 24R,28R- and 24S,28R-epoxy-24-ethylcholesterol at the ratio of 3 to 2 (2), and 24R-saringosterol (3), all of which exhibited proliferation activity on MG63 cells.

Original language	English
Pages (from-to)	551-555
Number of pages	5
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume	55
Issue number	4
DOIs	https://doi.org/10.1007/s13765-012-2069-6
State	Published - Aug 2012

Keywords

24,28-epoxy-24-ethylcholesterol
24R-saringosterol
fucosterol
Hizikia fusiformis
osteosarcoma

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10.1007/s13765-012-2069-6

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title = "Fucosterols from Hizikia fusiformis and their proliferation activities on osteosarcoma-derived cell MG63",

abstract = "Four fucosterol derivatives were isolated from the ethyl acetate fraction of Hizikia fusiformis. The chemical structures of the sterols were elucidated as fucosterol (1), a mixture of 24R,28R- and 24S,28R-epoxy-24-ethylcholesterol at the ratio of 3 to 2 (2), and 24R-saringosterol (3), all of which exhibited proliferation activity on MG63 cells.",

keywords = "24,28-epoxy-24-ethylcholesterol, 24R-saringosterol, fucosterol, Hizikia fusiformis, osteosarcoma",

author = "Huh, {Gyu Won} and Lee, {Dae Young} and In, {Suh Ji} and Lee, {Don Gil} and Park, {Sang Yong} and Yi, {Tae Hoo} and Kang, {Hee Cheol} and Seo, {Woo Duck} and Baek, {Nam In}",

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language = "English",

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T1 - Fucosterols from Hizikia fusiformis and their proliferation activities on osteosarcoma-derived cell MG63

AU - Huh, Gyu Won

AU - Lee, Dae Young

AU - In, Suh Ji

AU - Lee, Don Gil

AU - Park, Sang Yong

AU - Yi, Tae Hoo

AU - Kang, Hee Cheol

AU - Seo, Woo Duck

AU - Baek, Nam In

PY - 2012/8

Y1 - 2012/8

N2 - Four fucosterol derivatives were isolated from the ethyl acetate fraction of Hizikia fusiformis. The chemical structures of the sterols were elucidated as fucosterol (1), a mixture of 24R,28R- and 24S,28R-epoxy-24-ethylcholesterol at the ratio of 3 to 2 (2), and 24R-saringosterol (3), all of which exhibited proliferation activity on MG63 cells.

AB - Four fucosterol derivatives were isolated from the ethyl acetate fraction of Hizikia fusiformis. The chemical structures of the sterols were elucidated as fucosterol (1), a mixture of 24R,28R- and 24S,28R-epoxy-24-ethylcholesterol at the ratio of 3 to 2 (2), and 24R-saringosterol (3), all of which exhibited proliferation activity on MG63 cells.

KW - 24,28-epoxy-24-ethylcholesterol

KW - 24R-saringosterol

KW - fucosterol

KW - Hizikia fusiformis

KW - osteosarcoma

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M3 - Article

AN - SCOPUS:84866124896

SN - 1738-2203

VL - 55

SP - 551

EP - 555

JO - Journal of the Korean Society for Applied Biological Chemistry

JF - Journal of the Korean Society for Applied Biological Chemistry

IS - 4

ER -

Fucosterols from Hizikia fusiformis and their proliferation activities on osteosarcoma-derived cell MG63

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Keywords

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