Fucosterols from Hizikia fusiformis and their proliferation activities on osteosarcoma-derived cell MG63

Gyu Won Huh; Dae Young Lee; Suh Ji In; Don Gil Lee; Sang Yong Park; Tae Hoo Yi; Hee Cheol Kang; Woo Duck Seo; Nam In Baek

doi:10.1007/s13765-012-2069-6

Fucosterols from Hizikia fusiformis and their proliferation activities on osteosarcoma-derived cell MG63

Gyu Won Huh
, Dae Young Lee
, Suh Ji In
, Don Gil Lee
, Sang Yong Park
, Tae Hoo Yi
, Hee Cheol Kang
, Woo Duck Seo
, Nam In Baek

School of Life Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Four fucosterol derivatives were isolated from the ethyl acetate fraction of Hizikia fusiformis. The chemical structures of the sterols were elucidated as fucosterol (1), a mixture of 24R,28R- and 24S,28R-epoxy-24-ethylcholesterol at the ratio of 3 to 2 (2), and 24R-saringosterol (3), all of which exhibited proliferation activity on MG63 cells.

Original language	English
Pages (from-to)	551-555
Number of pages	5
Journal	Journal of the Korean Society for Applied Biological Chemistry
Volume	55
Issue number	4
DOIs	https://doi.org/10.1007/s13765-012-2069-6
State	Published - Aug 2012

Keywords

24,28-epoxy-24-ethylcholesterol
24R-saringosterol
Hizikia fusiformis
fucosterol
osteosarcoma

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10.1007/s13765-012-2069-6

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title = "Fucosterols from Hizikia fusiformis and their proliferation activities on osteosarcoma-derived cell MG63",

abstract = "Four fucosterol derivatives were isolated from the ethyl acetate fraction of Hizikia fusiformis. The chemical structures of the sterols were elucidated as fucosterol (1), a mixture of 24R,28R- and 24S,28R-epoxy-24-ethylcholesterol at the ratio of 3 to 2 (2), and 24R-saringosterol (3), all of which exhibited proliferation activity on MG63 cells.",

keywords = "24,28-epoxy-24-ethylcholesterol, 24R-saringosterol, Hizikia fusiformis, fucosterol, osteosarcoma",

author = "Huh, \{Gyu Won\} and Lee, \{Dae Young\} and In, \{Suh Ji\} and Lee, \{Don Gil\} and Park, \{Sang Yong\} and Yi, \{Tae Hoo\} and Kang, \{Hee Cheol\} and Seo, \{Woo Duck\} and Baek, \{Nam In\}",

year = "2012",

month = aug,

doi = "10.1007/s13765-012-2069-6",

language = "English",

volume = "55",

pages = "551--555",

journal = "Journal of the Korean Society for Applied Biological Chemistry",

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TY - JOUR

T1 - Fucosterols from Hizikia fusiformis and their proliferation activities on osteosarcoma-derived cell MG63

AU - Huh, Gyu Won

AU - Lee, Dae Young

AU - In, Suh Ji

AU - Lee, Don Gil

AU - Park, Sang Yong

AU - Yi, Tae Hoo

AU - Kang, Hee Cheol

AU - Seo, Woo Duck

AU - Baek, Nam In

PY - 2012/8

Y1 - 2012/8

N2 - Four fucosterol derivatives were isolated from the ethyl acetate fraction of Hizikia fusiformis. The chemical structures of the sterols were elucidated as fucosterol (1), a mixture of 24R,28R- and 24S,28R-epoxy-24-ethylcholesterol at the ratio of 3 to 2 (2), and 24R-saringosterol (3), all of which exhibited proliferation activity on MG63 cells.

AB - Four fucosterol derivatives were isolated from the ethyl acetate fraction of Hizikia fusiformis. The chemical structures of the sterols were elucidated as fucosterol (1), a mixture of 24R,28R- and 24S,28R-epoxy-24-ethylcholesterol at the ratio of 3 to 2 (2), and 24R-saringosterol (3), all of which exhibited proliferation activity on MG63 cells.

KW - 24,28-epoxy-24-ethylcholesterol

KW - 24R-saringosterol

KW - Hizikia fusiformis

KW - fucosterol

KW - osteosarcoma

UR - https://www.scopus.com/pages/publications/84866124896

U2 - 10.1007/s13765-012-2069-6

DO - 10.1007/s13765-012-2069-6

M3 - Article

AN - SCOPUS:84866124896

SN - 1738-2203

VL - 55

SP - 551

EP - 555

JO - Journal of the Korean Society for Applied Biological Chemistry

JF - Journal of the Korean Society for Applied Biological Chemistry

IS - 4

ER -

Fucosterols from Hizikia fusiformis and their proliferation activities on osteosarcoma-derived cell MG63

Abstract

Keywords

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