Fully implantable and bioresorbable cardiac pacemakers without leads or batteries

Yeon Sik Choi; Rose T. Yin; Anna Pfenniger; Jahyun Koo; Raudel Avila; K. Benjamin Lee; Sheena W. Chen; Geumbee Lee; Gang Li; Yun Qiao; Alejandro Murillo-Berlioz; Alexi Kiss; Shuling Han; Seung Min Lee; Chenhang Li; Zhaoqian Xie; Yu Yu Chen; Amy Burrell; Beth Geist; Hyoyoung Jeong; Joohee Kim; Hong Joon Yoon; Anthony Banks; Seung Kyun Kang; Zheng Jenny Zhang; Chad R. Haney; Alan Varteres Sahakian; David Johnson; Tatiana Efimova; Yonggang Huang; Gregory D. Trachiotis; Bradley P. Knight; Rishi K. Arora; Igor R. Efimov; John A. Rogers

doi:10.1038/s41587-021-00948-x

Fully implantable and bioresorbable cardiac pacemakers without leads or batteries

Yeon Sik Choi, Rose T. Yin, Anna Pfenniger, Jahyun Koo, Raudel Avila, K. Benjamin Lee, Sheena W. Chen, Geumbee Lee, Gang Li, Yun Qiao, Alejandro Murillo-Berlioz, Alexi Kiss, Shuling Han, Seung Min Lee, Chenhang Li, Zhaoqian Xie, Yu Yu Chen, Amy Burrell, Beth Geist, Hyoyoung JeongJoohee Kim, Hong Joon Yoon, Anthony Banks, Seung Kyun Kang, Zheng Jenny Zhang, Chad R. Haney, Alan Varteres Sahakian, David Johnson, Tatiana Efimova, Yonggang Huang, Gregory D. Trachiotis, Bradley P. Knight, Rishi K. Arora, Igor R. Efimov, John A. Rogers

Department of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

274 Scopus citations

Abstract

Temporary cardiac pacemakers used in periods of need during surgical recovery involve percutaneous leads and externalized hardware that carry risks of infection, constrain patient mobility and may damage the heart during lead removal. Here we report a leadless, battery-free, fully implantable cardiac pacemaker for postoperative control of cardiac rate and rhythm that undergoes complete dissolution and clearance by natural biological processes after a defined operating timeframe. We show that these devices provide effective pacing of hearts of various sizes in mouse, rat, rabbit, canine and human cardiac models, with tailored geometries and operation timescales, powered by wireless energy transfer. This approach overcomes key disadvantages of traditional temporary pacing devices and may serve as the basis for the next generation of postoperative temporary pacing technology.

Original language	English
Pages (from-to)	1228-1238
Number of pages	11
Journal	Nature Biotechnology
Volume	39
Issue number	10
DOIs	https://doi.org/10.1038/s41587-021-00948-x
State	Published - Oct 2021

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Choi, Y. S., Yin, R. T., Pfenniger, A., Koo, J., Avila, R., Benjamin Lee, K., Chen, S. W., Lee, G., Li, G., Qiao, Y., Murillo-Berlioz, A., Kiss, A., Han, S., Lee, S. M., Li, C., Xie, Z., Chen, Y. Y., Burrell, A., Geist, B., ... Rogers, J. A. (2021). Fully implantable and bioresorbable cardiac pacemakers without leads or batteries. Nature Biotechnology, 39(10), 1228-1238. https://doi.org/10.1038/s41587-021-00948-x

@article{9394ef0b89e24355a685ea628217326e,

title = "Fully implantable and bioresorbable cardiac pacemakers without leads or batteries",

abstract = "Temporary cardiac pacemakers used in periods of need during surgical recovery involve percutaneous leads and externalized hardware that carry risks of infection, constrain patient mobility and may damage the heart during lead removal. Here we report a leadless, battery-free, fully implantable cardiac pacemaker for postoperative control of cardiac rate and rhythm that undergoes complete dissolution and clearance by natural biological processes after a defined operating timeframe. We show that these devices provide effective pacing of hearts of various sizes in mouse, rat, rabbit, canine and human cardiac models, with tailored geometries and operation timescales, powered by wireless energy transfer. This approach overcomes key disadvantages of traditional temporary pacing devices and may serve as the basis for the next generation of postoperative temporary pacing technology.",

author = "Choi, \{Yeon Sik\} and Yin, \{Rose T.\} and Anna Pfenniger and Jahyun Koo and Raudel Avila and \{Benjamin Lee\}, K. and Chen, \{Sheena W.\} and Geumbee Lee and Gang Li and Yun Qiao and Alejandro Murillo-Berlioz and Alexi Kiss and Shuling Han and Lee, \{Seung Min\} and Chenhang Li and Zhaoqian Xie and Chen, \{Yu Yu\} and Amy Burrell and Beth Geist and Hyoyoung Jeong and Joohee Kim and Yoon, \{Hong Joon\} and Anthony Banks and Kang, \{Seung Kyun\} and Zhang, \{Zheng Jenny\} and Haney, \{Chad R.\} and Sahakian, \{Alan Varteres\} and David Johnson and Tatiana Efimova and Yonggang Huang and Trachiotis, \{Gregory D.\} and Knight, \{Bradley P.\} and Arora, \{Rishi K.\} and Efimov, \{Igor R.\} and Rogers, \{John A.\}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2021",

month = oct,

doi = "10.1038/s41587-021-00948-x",

language = "English",

volume = "39",

pages = "1228--1238",

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Choi, YS, Yin, RT, Pfenniger, A, Koo, J, Avila, R, Benjamin Lee, K, Chen, SW, Lee, G, Li, G, Qiao, Y, Murillo-Berlioz, A, Kiss, A, Han, S, Lee, SM, Li, C, Xie, Z, Chen, YY, Burrell, A, Geist, B, Jeong, H, Kim, J, Yoon, HJ, Banks, A, Kang, SK, Zhang, ZJ, Haney, CR, Sahakian, AV, Johnson, D, Efimova, T, Huang, Y, Trachiotis, GD, Knight, BP, Arora, RK, Efimov, IR & Rogers, JA 2021, 'Fully implantable and bioresorbable cardiac pacemakers without leads or batteries', Nature Biotechnology, vol. 39, no. 10, pp. 1228-1238. https://doi.org/10.1038/s41587-021-00948-x

TY - JOUR

T1 - Fully implantable and bioresorbable cardiac pacemakers without leads or batteries

AU - Choi, Yeon Sik

AU - Yin, Rose T.

AU - Pfenniger, Anna

AU - Koo, Jahyun

AU - Avila, Raudel

AU - Benjamin Lee, K.

AU - Chen, Sheena W.

AU - Lee, Geumbee

AU - Li, Gang

AU - Qiao, Yun

AU - Murillo-Berlioz, Alejandro

AU - Kiss, Alexi

AU - Han, Shuling

AU - Lee, Seung Min

AU - Li, Chenhang

AU - Xie, Zhaoqian

AU - Chen, Yu Yu

AU - Burrell, Amy

AU - Geist, Beth

AU - Jeong, Hyoyoung

AU - Kim, Joohee

AU - Yoon, Hong Joon

AU - Banks, Anthony

AU - Kang, Seung Kyun

AU - Zhang, Zheng Jenny

AU - Haney, Chad R.

AU - Sahakian, Alan Varteres

AU - Johnson, David

AU - Efimova, Tatiana

AU - Huang, Yonggang

AU - Trachiotis, Gregory D.

AU - Knight, Bradley P.

AU - Arora, Rishi K.

AU - Efimov, Igor R.

AU - Rogers, John A.

PY - 2021/10

Y1 - 2021/10

N2 - Temporary cardiac pacemakers used in periods of need during surgical recovery involve percutaneous leads and externalized hardware that carry risks of infection, constrain patient mobility and may damage the heart during lead removal. Here we report a leadless, battery-free, fully implantable cardiac pacemaker for postoperative control of cardiac rate and rhythm that undergoes complete dissolution and clearance by natural biological processes after a defined operating timeframe. We show that these devices provide effective pacing of hearts of various sizes in mouse, rat, rabbit, canine and human cardiac models, with tailored geometries and operation timescales, powered by wireless energy transfer. This approach overcomes key disadvantages of traditional temporary pacing devices and may serve as the basis for the next generation of postoperative temporary pacing technology.

AB - Temporary cardiac pacemakers used in periods of need during surgical recovery involve percutaneous leads and externalized hardware that carry risks of infection, constrain patient mobility and may damage the heart during lead removal. Here we report a leadless, battery-free, fully implantable cardiac pacemaker for postoperative control of cardiac rate and rhythm that undergoes complete dissolution and clearance by natural biological processes after a defined operating timeframe. We show that these devices provide effective pacing of hearts of various sizes in mouse, rat, rabbit, canine and human cardiac models, with tailored geometries and operation timescales, powered by wireless energy transfer. This approach overcomes key disadvantages of traditional temporary pacing devices and may serve as the basis for the next generation of postoperative temporary pacing technology.

UR - https://www.scopus.com/pages/publications/85109882860

U2 - 10.1038/s41587-021-00948-x

DO - 10.1038/s41587-021-00948-x

M3 - Article

C2 - 34183859

AN - SCOPUS:85109882860

SN - 1087-0156

VL - 39

SP - 1228

EP - 1238

JO - Nature Biotechnology

JF - Nature Biotechnology

IS - 10

ER -

Fully implantable and bioresorbable cardiac pacemakers without leads or batteries

Abstract

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