Fully waterproof two-axis galvanometer scanner for enhanced wide-field optical-resolution photoacoustic microscopy

Jaeyul Lee; Sangyeob Han; Daewoon Seong; Junsoo Lee; Sungjo Park; Ruchire Eranga Wijesinghe; Mansik Jeon; Jeehyun Kim

doi:10.1364/OL.380032

Fully waterproof two-axis galvanometer scanner for enhanced wide-field optical-resolution photoacoustic microscopy

Jaeyul Lee, Sangyeob Han, Daewoon Seong, Junsoo Lee, Sungjo Park, Ruchire Eranga Wijesinghe, Mansik Jeon, Jeehyun Kim

School of Electronics Engineering

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

A large field-of-view and fast scanning of photoacoustic microscopy (PAM) relatively have been difficult to obtain due to the water-drowned structure of the system for the transmission of ultrasonic signals. Researchers have widely studied the achievement of a waterproof scanner for dynamic biological applications with a high-resolution and high signal-to-noise ratio. This Letter reports a novel, to the best of our knowledge, waterproof galvanometer scanner-based PAM system with a successfully attainable 9.0 mm × 14.5 mm scan region, amplitude scan rate of 40 kHz, and spatial resolution of 4.9 µm. The in vivo characterization of a mouse brain in intact-skull microvascular visualization demonstrated its capability in biomedical imaging and is anticipated to be an effective technique for various preclinical and clinical studies.

Original language	English
Pages (from-to)	865-868
Number of pages	4
Journal	Optics Letters
Volume	45
Issue number	4
DOIs	https://doi.org/10.1364/OL.380032
State	Published - 15 Feb 2020

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title = "Fully waterproof two-axis galvanometer scanner for enhanced wide-field optical-resolution photoacoustic microscopy",

abstract = "A large field-of-view and fast scanning of photoacoustic microscopy (PAM) relatively have been difficult to obtain due to the water-drowned structure of the system for the transmission of ultrasonic signals. Researchers have widely studied the achievement of a waterproof scanner for dynamic biological applications with a high-resolution and high signal-to-noise ratio. This Letter reports a novel, to the best of our knowledge, waterproof galvanometer scanner-based PAM system with a successfully attainable 9.0 mm × 14.5 mm scan region, amplitude scan rate of 40 kHz, and spatial resolution of 4.9 µm. The in vivo characterization of a mouse brain in intact-skull microvascular visualization demonstrated its capability in biomedical imaging and is anticipated to be an effective technique for various preclinical and clinical studies.",

author = "Jaeyul Lee and Sangyeob Han and Daewoon Seong and Junsoo Lee and Sungjo Park and Wijesinghe, {Ruchire Eranga} and Mansik Jeon and Jeehyun Kim",

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AU - Lee, Jaeyul

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AU - Seong, Daewoon

AU - Lee, Junsoo

AU - Park, Sungjo

AU - Wijesinghe, Ruchire Eranga

AU - Jeon, Mansik

AU - Kim, Jeehyun

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Fully waterproof two-axis galvanometer scanner for enhanced wide-field optical-resolution photoacoustic microscopy

Abstract

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