Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics

Ji Hoon Yu; Chun Young Im; Sang Hyun Min

doi:10.3389/fcell.2020.00120

Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics

Ji Hoon Yu, Chun Young Im, Sang Hyun Min

Department of Innovative Pharmaceutical Sciences

Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF)

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

Peptidyl-prolyl isomerase (PIN1) specifically binds and isomerizes the phosphorylated serine/threonine–proline (pSer/Thr–Pro) motif, which results in the alteration of protein structure, function, and stability. The altered structure and function of these phosphorylated proteins regulated by PIN1 are closely related to cancer development. PIN1 is highly expressed in human cancers and promotes cancer as well as cancer stem cells by breaking the balance of oncogenes and tumor suppressors. In this review, we discuss the roles of PIN1 in cancer and PIN1-targeted small-molecule compounds.

Original language	English
Article number	120
Journal	Frontiers in Cell and Developmental Biology
Volume	8
DOIs	https://doi.org/10.3389/fcell.2020.00120
State	Published - 17 Mar 2020

Keywords

cancer therapeutics
PIN1
PIN1 inhibitor
proline-directed phosphorylation
prolyl isomerase
tumorigenesis

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10.3389/fcell.2020.00120

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title = "Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics",

abstract = "Peptidyl-prolyl isomerase (PIN1) specifically binds and isomerizes the phosphorylated serine/threonine–proline (pSer/Thr–Pro) motif, which results in the alteration of protein structure, function, and stability. The altered structure and function of these phosphorylated proteins regulated by PIN1 are closely related to cancer development. PIN1 is highly expressed in human cancers and promotes cancer as well as cancer stem cells by breaking the balance of oncogenes and tumor suppressors. In this review, we discuss the roles of PIN1 in cancer and PIN1-targeted small-molecule compounds.",

keywords = "cancer therapeutics, PIN1, PIN1 inhibitor, proline-directed phosphorylation, prolyl isomerase, tumorigenesis",

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AU - Yu, Ji Hoon

AU - Im, Chun Young

AU - Min, Sang Hyun

PY - 2020/3/17

Y1 - 2020/3/17

N2 - Peptidyl-prolyl isomerase (PIN1) specifically binds and isomerizes the phosphorylated serine/threonine–proline (pSer/Thr–Pro) motif, which results in the alteration of protein structure, function, and stability. The altered structure and function of these phosphorylated proteins regulated by PIN1 are closely related to cancer development. PIN1 is highly expressed in human cancers and promotes cancer as well as cancer stem cells by breaking the balance of oncogenes and tumor suppressors. In this review, we discuss the roles of PIN1 in cancer and PIN1-targeted small-molecule compounds.

AB - Peptidyl-prolyl isomerase (PIN1) specifically binds and isomerizes the phosphorylated serine/threonine–proline (pSer/Thr–Pro) motif, which results in the alteration of protein structure, function, and stability. The altered structure and function of these phosphorylated proteins regulated by PIN1 are closely related to cancer development. PIN1 is highly expressed in human cancers and promotes cancer as well as cancer stem cells by breaking the balance of oncogenes and tumor suppressors. In this review, we discuss the roles of PIN1 in cancer and PIN1-targeted small-molecule compounds.

KW - cancer therapeutics

KW - PIN1

KW - PIN1 inhibitor

KW - proline-directed phosphorylation

KW - prolyl isomerase

KW - tumorigenesis

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DO - 10.3389/fcell.2020.00120

M3 - Review article

AN - SCOPUS:85082691031

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VL - 8

JO - Frontiers in Cell and Developmental Biology

JF - Frontiers in Cell and Developmental Biology

M1 - 120

ER -

Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics

Abstract

Keywords

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