Gadolinium complex of 125I/127I-RGD-DOTA conjugate as a tumor-targeting SPECT/MR bimodal imaging probe

Ji Ae Park; Jung Young Kim; Yong Jin Lee; Wonho Lee; Sang Moo Lim; Tae Jeong Kim; Jeongsoo Yoo; Yongmin Chang; Kyeong Min Kim

doi:10.1021/ml3003499

Gadolinium complex of ¹²⁵I/¹²⁷I-RGD-DOTA conjugate as a tumor-targeting SPECT/MR bimodal imaging probe

Ji Ae Park
, Jung Young Kim
, Yong Jin Lee
, Wonho Lee
, Sang Moo Lim
, Tae Jeong Kim
, Jeongsoo Yoo
, Yongmin Chang
, Kyeong Min Kim

Korea Institute of Radiological and Medical Sciences
Kyungpook National University

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

The work describes the synthesis and in vivo application of [Gd(L)(H ₂O)]·xH₂O, where L is a (¹²⁵I/ ¹²⁷I-RGD)- DOTA conjugate, as a tumor-targeting SPECT/MR bimodal imaging probe. Here, (¹²⁵I/¹²⁷I-RGD)-DOTA signifies a "cocktail mixture" of radioisotopic (1a, L = ¹²⁵I-RGD-DOTA) and natural (1b, L = ¹²⁷I-RGD-DOTA) Gd complexes. The two complexes are chemically equivalent as revealed by HPLC, and their cocktail mixture exhibits the integrin-specific tumor enhancement, demonstrating that they constitute essentially a single bimodal imaging probe. Employment of a cocktail mixture thus proves to be a sole and practical approach to overcome the sensitivity difference problem between MRI and SPECT.

Original language	English
Pages (from-to)	216-219
Number of pages	4
Journal	ACS Medicinal Chemistry Letters
Volume	4
Issue number	2
DOIs	https://doi.org/10.1021/ml3003499
State	Published - 14 Feb 2013

Keywords

RGD peptide
SPECT/MR
dual modality
small molecule
tumor targeting

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10.1021/ml3003499

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title = "Gadolinium complex of 125I/127I-RGD-DOTA conjugate as a tumor-targeting SPECT/MR bimodal imaging probe",

abstract = "The work describes the synthesis and in vivo application of [Gd(L)(H 2O)]·xH2O, where L is a (125I/ 127I-RGD)- DOTA conjugate, as a tumor-targeting SPECT/MR bimodal imaging probe. Here, (125I/127I-RGD)-DOTA signifies a {"}cocktail mixture{"} of radioisotopic (1a, L = 125I-RGD-DOTA) and natural (1b, L = 127I-RGD-DOTA) Gd complexes. The two complexes are chemically equivalent as revealed by HPLC, and their cocktail mixture exhibits the integrin-specific tumor enhancement, demonstrating that they constitute essentially a single bimodal imaging probe. Employment of a cocktail mixture thus proves to be a sole and practical approach to overcome the sensitivity difference problem between MRI and SPECT.",

keywords = "RGD peptide, SPECT/MR, dual modality, small molecule, tumor targeting",

author = "Park, \{Ji Ae\} and Kim, \{Jung Young\} and Lee, \{Yong Jin\} and Wonho Lee and Lim, \{Sang Moo\} and Kim, \{Tae Jeong\} and Jeongsoo Yoo and Yongmin Chang and Kim, \{Kyeong Min\}",

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doi = "10.1021/ml3003499",

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journal = "ACS Medicinal Chemistry Letters",

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AU - Park, Ji Ae

AU - Kim, Jung Young

AU - Lee, Yong Jin

AU - Lee, Wonho

AU - Lim, Sang Moo

AU - Kim, Tae Jeong

AU - Yoo, Jeongsoo

AU - Chang, Yongmin

AU - Kim, Kyeong Min

PY - 2013/2/14

Y1 - 2013/2/14

N2 - The work describes the synthesis and in vivo application of [Gd(L)(H 2O)]·xH2O, where L is a (125I/ 127I-RGD)- DOTA conjugate, as a tumor-targeting SPECT/MR bimodal imaging probe. Here, (125I/127I-RGD)-DOTA signifies a "cocktail mixture" of radioisotopic (1a, L = 125I-RGD-DOTA) and natural (1b, L = 127I-RGD-DOTA) Gd complexes. The two complexes are chemically equivalent as revealed by HPLC, and their cocktail mixture exhibits the integrin-specific tumor enhancement, demonstrating that they constitute essentially a single bimodal imaging probe. Employment of a cocktail mixture thus proves to be a sole and practical approach to overcome the sensitivity difference problem between MRI and SPECT.

AB - The work describes the synthesis and in vivo application of [Gd(L)(H 2O)]·xH2O, where L is a (125I/ 127I-RGD)- DOTA conjugate, as a tumor-targeting SPECT/MR bimodal imaging probe. Here, (125I/127I-RGD)-DOTA signifies a "cocktail mixture" of radioisotopic (1a, L = 125I-RGD-DOTA) and natural (1b, L = 127I-RGD-DOTA) Gd complexes. The two complexes are chemically equivalent as revealed by HPLC, and their cocktail mixture exhibits the integrin-specific tumor enhancement, demonstrating that they constitute essentially a single bimodal imaging probe. Employment of a cocktail mixture thus proves to be a sole and practical approach to overcome the sensitivity difference problem between MRI and SPECT.

KW - RGD peptide

KW - SPECT/MR

KW - dual modality

KW - small molecule

KW - tumor targeting

UR - https://www.scopus.com/pages/publications/84873940870

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DO - 10.1021/ml3003499

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JO - ACS Medicinal Chemistry Letters

JF - ACS Medicinal Chemistry Letters

IS - 2

ER -

Gadolinium complex of ¹²⁵I/¹²⁷I-RGD-DOTA conjugate as a tumor-targeting SPECT/MR bimodal imaging probe

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Keywords

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