Gallic acid inhibits vascular calcification through the blockade of BMP2-Smad1/5/8 signaling pathway

Hae Jin Kee; Soo Na Cho; Gwi Ran Kim; Sin Young Choi; Yuhee Ryu; In Kyeom Kim; Young Joon Hong; Hyung Wook Park; Youngkeun Ahn; Jeong Gwan Cho; Jong Chun Park; Myung Ho Jeong

doi:10.1016/j.vph.2014.08.005

Gallic acid inhibits vascular calcification through the blockade of BMP2-Smad1/5/8 signaling pathway

Hae Jin Kee, Soo Na Cho, Gwi Ran Kim, Sin Young Choi, Yuhee Ryu, In Kyeom Kim, Young Joon Hong, Hyung Wook Park, Youngkeun Ahn, Jeong Gwan Cho, Jong Chun Park, Myung Ho Jeong

Department of Medicine

Chonnam National University

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Vascular calcification is associated with increased risk of morbidity and mortality in patients with cardiovascular diseases, chronic kidney diseases, and diabetes. Gallic acid, a natural compound found in gallnut and green tea, is known to be antifungal, antioxidant, and anticancer. Here we investigated the effect of gallic acid on vascular smooth muscle cell (VSMC) calcification and the underlying mechanism.Gallic acid inhibited inorganic phosphate-induced osteoblast differentiation markers as well as calcification phenotypes (as determined by calcium deposition, Alizarin Red, and Von Kossa staining). Knockdown of BMP2 or Noggin blocked phosphate-induced calcification. Gallic acid suppressed phosphorylation of Smad1/5/8 protein induced by inorganic phosphate. Taken together, we suggest that gallic acid acts as a novel therapeutic agent of vascular calcification by mediating BMP2-Smad1/5/8 signaling pathway.

Original language	English
Pages (from-to)	71-78
Number of pages	8
Journal	Vascular Pharmacology
Volume	63
Issue number	2
DOIs	https://doi.org/10.1016/j.vph.2014.08.005
State	Published - 2014

Keywords

BMP2
Gallic acid
Noggin
Smad1/5/8 signaling
Vascular calcification

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vph.2014.08.005

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title = "Gallic acid inhibits vascular calcification through the blockade of BMP2-Smad1/5/8 signaling pathway",

abstract = "Vascular calcification is associated with increased risk of morbidity and mortality in patients with cardiovascular diseases, chronic kidney diseases, and diabetes. Gallic acid, a natural compound found in gallnut and green tea, is known to be antifungal, antioxidant, and anticancer. Here we investigated the effect of gallic acid on vascular smooth muscle cell (VSMC) calcification and the underlying mechanism.Gallic acid inhibited inorganic phosphate-induced osteoblast differentiation markers as well as calcification phenotypes (as determined by calcium deposition, Alizarin Red, and Von Kossa staining). Knockdown of BMP2 or Noggin blocked phosphate-induced calcification. Gallic acid suppressed phosphorylation of Smad1/5/8 protein induced by inorganic phosphate. Taken together, we suggest that gallic acid acts as a novel therapeutic agent of vascular calcification by mediating BMP2-Smad1/5/8 signaling pathway.",

keywords = "BMP2, Gallic acid, Noggin, Smad1/5/8 signaling, Vascular calcification",

author = "Kee, {Hae Jin} and Cho, {Soo Na} and Kim, {Gwi Ran} and Choi, {Sin Young} and Yuhee Ryu and Kim, {In Kyeom} and Hong, {Young Joon} and Park, {Hyung Wook} and Youngkeun Ahn and Cho, {Jeong Gwan} and Park, {Jong Chun} and Jeong, {Myung Ho}",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",

year = "2014",

doi = "10.1016/j.vph.2014.08.005",

language = "English",

volume = "63",

pages = "71--78",

journal = "Vascular Pharmacology",

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T1 - Gallic acid inhibits vascular calcification through the blockade of BMP2-Smad1/5/8 signaling pathway

AU - Kee, Hae Jin

AU - Cho, Soo Na

AU - Kim, Gwi Ran

AU - Choi, Sin Young

AU - Ryu, Yuhee

AU - Kim, In Kyeom

AU - Hong, Young Joon

AU - Park, Hyung Wook

AU - Ahn, Youngkeun

AU - Cho, Jeong Gwan

AU - Park, Jong Chun

AU - Jeong, Myung Ho

PY - 2014

Y1 - 2014

N2 - Vascular calcification is associated with increased risk of morbidity and mortality in patients with cardiovascular diseases, chronic kidney diseases, and diabetes. Gallic acid, a natural compound found in gallnut and green tea, is known to be antifungal, antioxidant, and anticancer. Here we investigated the effect of gallic acid on vascular smooth muscle cell (VSMC) calcification and the underlying mechanism.Gallic acid inhibited inorganic phosphate-induced osteoblast differentiation markers as well as calcification phenotypes (as determined by calcium deposition, Alizarin Red, and Von Kossa staining). Knockdown of BMP2 or Noggin blocked phosphate-induced calcification. Gallic acid suppressed phosphorylation of Smad1/5/8 protein induced by inorganic phosphate. Taken together, we suggest that gallic acid acts as a novel therapeutic agent of vascular calcification by mediating BMP2-Smad1/5/8 signaling pathway.

AB - Vascular calcification is associated with increased risk of morbidity and mortality in patients with cardiovascular diseases, chronic kidney diseases, and diabetes. Gallic acid, a natural compound found in gallnut and green tea, is known to be antifungal, antioxidant, and anticancer. Here we investigated the effect of gallic acid on vascular smooth muscle cell (VSMC) calcification and the underlying mechanism.Gallic acid inhibited inorganic phosphate-induced osteoblast differentiation markers as well as calcification phenotypes (as determined by calcium deposition, Alizarin Red, and Von Kossa staining). Knockdown of BMP2 or Noggin blocked phosphate-induced calcification. Gallic acid suppressed phosphorylation of Smad1/5/8 protein induced by inorganic phosphate. Taken together, we suggest that gallic acid acts as a novel therapeutic agent of vascular calcification by mediating BMP2-Smad1/5/8 signaling pathway.

KW - BMP2

KW - Gallic acid

KW - Noggin

KW - Smad1/5/8 signaling

KW - Vascular calcification

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U2 - 10.1016/j.vph.2014.08.005

DO - 10.1016/j.vph.2014.08.005

M3 - Article

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AN - SCOPUS:84927606062

SN - 1537-1891

VL - 63

SP - 71

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JO - Vascular Pharmacology

JF - Vascular Pharmacology

IS - 2

ER -

Gallic acid inhibits vascular calcification through the blockade of BMP2-Smad1/5/8 signaling pathway

Abstract

Keywords

UN SDGs

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