Gd-complexes of macrocyclic DTPA conjugates of 1,1′-bis(amino) ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs)

Hee Kyung Kim; Ji Ae Park; Kyeong Min Kim; Nasiruzzaman Sk Md.; Duk Sik Kang; Jongmin Lee; Yongmin Chang; Tae Jeong Kim

doi:10.1039/c0cc03145c

Gd-complexes of macrocyclic DTPA conjugates of 1,1′-bis(amino) ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs)

Hee Kyung Kim, Ji Ae Park, Kyeong Min Kim, Nasiruzzaman Sk Md., Duk Sik Kang, Jongmin Lee, Yongmin Chang, Tae Jeong Kim

Department of Medicine

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

We report the synthesis of macrocyclic DTPA conjugates of 1,1′-bis(amino)ferrocenes (1a-b) and their Gd-complexes [Gd(L)(H ₂O)] (2a-b, L = 1a-b) for use as new MRI blood-pool contrast agents. High R₁ relaxivity in HSA as well as high thermodynamic and kinetic stabilities is observed for 2a.

Original language	English
Pages (from-to)	8442-8444
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	44
DOIs	https://doi.org/10.1039/c0cc03145c
State	Published - 28 Nov 2010

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title = "Gd-complexes of macrocyclic DTPA conjugates of 1,1′-bis(amino) ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs)",

abstract = "We report the synthesis of macrocyclic DTPA conjugates of 1,1′-bis(amino)ferrocenes (1a-b) and their Gd-complexes [Gd(L)(H 2O)] (2a-b, L = 1a-b) for use as new MRI blood-pool contrast agents. High R1 relaxivity in HSA as well as high thermodynamic and kinetic stabilities is observed for 2a.",

author = "Kim, {Hee Kyung} and Park, {Ji Ae} and Kim, {Kyeong Min} and {Sk Md.}, Nasiruzzaman and Kang, {Duk Sik} and Jongmin Lee and Yongmin Chang and Kim, {Tae Jeong}",

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T1 - Gd-complexes of macrocyclic DTPA conjugates of 1,1′-bis(amino) ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs)

AU - Kim, Hee Kyung

AU - Park, Ji Ae

AU - Kim, Kyeong Min

AU - Sk Md., Nasiruzzaman

AU - Kang, Duk Sik

AU - Lee, Jongmin

AU - Chang, Yongmin

AU - Kim, Tae Jeong

PY - 2010/11/28

Y1 - 2010/11/28

N2 - We report the synthesis of macrocyclic DTPA conjugates of 1,1′-bis(amino)ferrocenes (1a-b) and their Gd-complexes [Gd(L)(H 2O)] (2a-b, L = 1a-b) for use as new MRI blood-pool contrast agents. High R1 relaxivity in HSA as well as high thermodynamic and kinetic stabilities is observed for 2a.

AB - We report the synthesis of macrocyclic DTPA conjugates of 1,1′-bis(amino)ferrocenes (1a-b) and their Gd-complexes [Gd(L)(H 2O)] (2a-b, L = 1a-b) for use as new MRI blood-pool contrast agents. High R1 relaxivity in HSA as well as high thermodynamic and kinetic stabilities is observed for 2a.

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U2 - 10.1039/c0cc03145c

DO - 10.1039/c0cc03145c

M3 - Article

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AN - SCOPUS:78049409330

SN - 1359-7345

VL - 46

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EP - 8444

JO - Chemical Communications

JF - Chemical Communications

IS - 44

ER -

Gd-complexes of macrocyclic DTPA conjugates of 1,1′-bis(amino) ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs)

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