Gd-complexes of macrocyclic DTPA conjugates of 1,1′-bis(amino) ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs)

Hee Kyung Kim; Ji Ae Park; Kyeong Min Kim; Nasiruzzaman Sk Md.; Duk Sik Kang; Jongmin Lee; Yongmin Chang; Tae Jeong Kim

doi:10.1039/c0cc03145c

Gd-complexes of macrocyclic DTPA conjugates of 1,1′-bis(amino) ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs)

Hee Kyung Kim
, Ji Ae Park
, Kyeong Min Kim
, Nasiruzzaman Sk Md.
, Duk Sik Kang
, Jongmin Lee
, Yongmin Chang
, Tae Jeong Kim

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

We report the synthesis of macrocyclic DTPA conjugates of 1,1′-bis(amino)ferrocenes (1a-b) and their Gd-complexes [Gd(L)(H ₂O)] (2a-b, L = 1a-b) for use as new MRI blood-pool contrast agents. High R₁ relaxivity in HSA as well as high thermodynamic and kinetic stabilities is observed for 2a.

Original language	English
Pages (from-to)	8442-8444
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	44
DOIs	https://doi.org/10.1039/c0cc03145c
State	Published - 28 Nov 2010

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title = "Gd-complexes of macrocyclic DTPA conjugates of 1,1′-bis(amino) ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs)",

abstract = "We report the synthesis of macrocyclic DTPA conjugates of 1,1′-bis(amino)ferrocenes (1a-b) and their Gd-complexes [Gd(L)(H 2O)] (2a-b, L = 1a-b) for use as new MRI blood-pool contrast agents. High R1 relaxivity in HSA as well as high thermodynamic and kinetic stabilities is observed for 2a.",

author = "Kim, \{Hee Kyung\} and Park, \{Ji Ae\} and Kim, \{Kyeong Min\} and \{Sk Md.\}, Nasiruzzaman and Kang, \{Duk Sik\} and Jongmin Lee and Yongmin Chang and Kim, \{Tae Jeong\}",

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doi = "10.1039/c0cc03145c",

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T1 - Gd-complexes of macrocyclic DTPA conjugates of 1,1′-bis(amino) ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs)

AU - Kim, Hee Kyung

AU - Park, Ji Ae

AU - Kim, Kyeong Min

AU - Sk Md., Nasiruzzaman

AU - Kang, Duk Sik

AU - Lee, Jongmin

AU - Chang, Yongmin

AU - Kim, Tae Jeong

PY - 2010/11/28

Y1 - 2010/11/28

N2 - We report the synthesis of macrocyclic DTPA conjugates of 1,1′-bis(amino)ferrocenes (1a-b) and their Gd-complexes [Gd(L)(H 2O)] (2a-b, L = 1a-b) for use as new MRI blood-pool contrast agents. High R1 relaxivity in HSA as well as high thermodynamic and kinetic stabilities is observed for 2a.

AB - We report the synthesis of macrocyclic DTPA conjugates of 1,1′-bis(amino)ferrocenes (1a-b) and their Gd-complexes [Gd(L)(H 2O)] (2a-b, L = 1a-b) for use as new MRI blood-pool contrast agents. High R1 relaxivity in HSA as well as high thermodynamic and kinetic stabilities is observed for 2a.

UR - https://www.scopus.com/pages/publications/78049409330

U2 - 10.1039/c0cc03145c

DO - 10.1039/c0cc03145c

M3 - Article

C2 - 20886175

AN - SCOPUS:78049409330

SN - 1359-7345

VL - 46

SP - 8442

EP - 8444

JO - Chemical Communications

JF - Chemical Communications

IS - 44

ER -

Gd-complexes of macrocyclic DTPA conjugates of 1,1′-bis(amino) ferrocenes as high relaxivity MRI blood-pool contrast agents (BPCAs)

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