Gene delivery using a novel cationic liposome with low toxicity

Hyungu Kang; Kyung Oh Doh; Young Bae Seu

Gene delivery using a novel cationic liposome with low toxicity

Hyungu Kang, Kyung Oh Doh, Young Bae Seu

School of Life Science and Biotechnology

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

Abstract

Cationic liposome has been studied as one of the most promising non-viral gene delivery systems. In this report, we describe a new synthesized cholesterolic cationic lipid (2-aminoethylcarbamate-cholesterol) and dioleylphosphatidylethanolamine (DOPE) improve the cellular uptake properties of antisense ODNs, as well as plasmid DNA with low toxicity. This formulation of cholesterolic cationic lipid termed Chol-E, efficiently transfects ODNs and plasmids into many cell types in the presense or absence of 10% serum in the medium.

Original language	English
Pages (from-to)	329-334
Number of pages	6
Journal	Microbiology and Biotechnology Letters
Volume	34
Issue number	4
State	Published - Dec 2006

Keywords

Cationic liposome
Cholesterolic cationic lipid
DOPE
Low toxicity transfection

Cite this

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AU - Doh, Kyung Oh

AU - Seu, Young Bae

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AB - Cationic liposome has been studied as one of the most promising non-viral gene delivery systems. In this report, we describe a new synthesized cholesterolic cationic lipid (2-aminoethylcarbamate-cholesterol) and dioleylphosphatidylethanolamine (DOPE) improve the cellular uptake properties of antisense ODNs, as well as plasmid DNA with low toxicity. This formulation of cholesterolic cationic lipid termed Chol-E, efficiently transfects ODNs and plasmids into many cell types in the presense or absence of 10% serum in the medium.

KW - Cationic liposome

KW - Cholesterolic cationic lipid

KW - DOPE

KW - Low toxicity transfection

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M3 - Article

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SN - 1598-642X

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EP - 334

JO - Microbiology and Biotechnology Letters

JF - Microbiology and Biotechnology Letters

IS - 4

ER -

Gene delivery using a novel cationic liposome with low toxicity

Abstract

Keywords

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