Gene delivery using a novel cationic liposome with low toxicity

Hyungu Kang; Kyung Oh Doh; Young Bae Seu

Gene delivery using a novel cationic liposome with low toxicity

Hyungu Kang, Kyung Oh Doh, Young Bae Seu

School of Life Science and Biotechnology

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

Abstract

Cationic liposome has been studied as one of the most promising non-viral gene delivery systems. In this report, we describe a new synthesized cholesterolic cationic lipid (2-aminoethylcarbamate-cholesterol) and dioleylphosphatidylethanolamine (DOPE) improve the cellular uptake properties of antisense ODNs, as well as plasmid DNA with low toxicity. This formulation of cholesterolic cationic lipid termed Chol-E, efficiently transfects ODNs and plasmids into many cell types in the presense or absence of 10% serum in the medium.

Original language	English
Pages (from-to)	329-334
Number of pages	6
Journal	Microbiology and Biotechnology Letters
Volume	34
Issue number	4
State	Published - Dec 2006

Keywords

Cationic liposome
Cholesterolic cationic lipid
DOPE
Low toxicity transfection

Cite this

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title = "Gene delivery using a novel cationic liposome with low toxicity",

abstract = "Cationic liposome has been studied as one of the most promising non-viral gene delivery systems. In this report, we describe a new synthesized cholesterolic cationic lipid (2-aminoethylcarbamate-cholesterol) and dioleylphosphatidylethanolamine (DOPE) improve the cellular uptake properties of antisense ODNs, as well as plasmid DNA with low toxicity. This formulation of cholesterolic cationic lipid termed Chol-E, efficiently transfects ODNs and plasmids into many cell types in the presense or absence of 10\% serum in the medium.",

keywords = "Cationic liposome, Cholesterolic cationic lipid, DOPE, Low toxicity transfection",

author = "Hyungu Kang and Doh, \{Kyung Oh\} and Seu, \{Young Bae\}",

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language = "English",

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pages = "329--334",

journal = "Microbiology and Biotechnology Letters",

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T1 - Gene delivery using a novel cationic liposome with low toxicity

AU - Kang, Hyungu

AU - Doh, Kyung Oh

AU - Seu, Young Bae

PY - 2006/12

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N2 - Cationic liposome has been studied as one of the most promising non-viral gene delivery systems. In this report, we describe a new synthesized cholesterolic cationic lipid (2-aminoethylcarbamate-cholesterol) and dioleylphosphatidylethanolamine (DOPE) improve the cellular uptake properties of antisense ODNs, as well as plasmid DNA with low toxicity. This formulation of cholesterolic cationic lipid termed Chol-E, efficiently transfects ODNs and plasmids into many cell types in the presense or absence of 10% serum in the medium.

AB - Cationic liposome has been studied as one of the most promising non-viral gene delivery systems. In this report, we describe a new synthesized cholesterolic cationic lipid (2-aminoethylcarbamate-cholesterol) and dioleylphosphatidylethanolamine (DOPE) improve the cellular uptake properties of antisense ODNs, as well as plasmid DNA with low toxicity. This formulation of cholesterolic cationic lipid termed Chol-E, efficiently transfects ODNs and plasmids into many cell types in the presense or absence of 10% serum in the medium.

KW - Cationic liposome

KW - Cholesterolic cationic lipid

KW - DOPE

KW - Low toxicity transfection

UR - https://www.scopus.com/pages/publications/33947432085

M3 - Article

AN - SCOPUS:33947432085

SN - 1598-642X

VL - 34

SP - 329

EP - 334

JO - Microbiology and Biotechnology Letters

JF - Microbiology and Biotechnology Letters

IS - 4

ER -

Gene delivery using a novel cationic liposome with low toxicity

Abstract

Keywords

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