Abstract
The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis providing a novel platform for cancer diagnosis and treatment.
Original language | English |
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Pages (from-to) | 2016-2026 |
Number of pages | 11 |
Journal | Journal of Cellular Biochemistry |
Volume | 104 |
Issue number | 6 |
DOIs | |
State | Published - 15 Aug 2008 |
Keywords
- Chromatin
- Epigenetic control
- Nuclear matrix
- Nuclear microenvironments
- Transcription