Genetic polymorphisms in glycolytic pathway are associated with the prognosis of patients with early stage non-small cell lung cancer

Shin Yup Lee; Cheng Cheng Jin; Jin Eun Choi; Mi Jeong Hong; Deuk Kju Jung; Sook Kyung Do; Sun Ah Baek; Hyo Jung Kang; Hyo Gyoung Kang; Sun Ha Choi; Won Kee Lee; Yangki Seok; Eung Bae Lee; Ji Yun Jeong; Kyung Min Shin; Sukki Cho; Seung Soo Yoo; Jaehee Lee; Seung Ick Cha; Chang Ho Kim; You Mie Lee; In Kyu Lee; Sanghoon Jheon; Jae Yong Park

doi:10.1038/srep35603

Genetic polymorphisms in glycolytic pathway are associated with the prognosis of patients with early stage non-small cell lung cancer

Shin Yup Lee, Cheng Cheng Jin, Jin Eun Choi, Mi Jeong Hong, Deuk Kju Jung, Sook Kyung Do, Sun Ah Baek, Hyo Jung Kang, Hyo Gyoung Kang, Sun Ha Choi, Won Kee Lee, Yangki Seok, Eung Bae Lee, Ji Yun Jeong, Kyung Min Shin, Sukki Cho, Seung Soo Yoo, Jaehee Lee, Seung Ick Cha, Chang Ho KimYou Mie Lee, In Kyu Lee, Sanghoon Jheon, Jae Yong Park

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

This study was conducted to investigate whether polymorphisms of genes involved in glycolysis are associated with the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Forty-four single nucleotide polymorphisms (SNPs) of 17 genes in glycolytic pathway were investigated in a total of 782 patients with NSCLC who underwent curative surgical resection. The association of the SNPs with overall survival (OS) and disease free survival (DFS) were analyzed. Among the 44 SNPs investigated, four SNPs (ENO1 rs2274971A > G, PFKM rs11168417C > T, PFKP rs1132173C > T, PDK2 rs3785921G > A) were significantly associated with survival outcomes in multivariate analyses. When stratified by tumor histology, three SNPs (ENO1 rs2274971A > G, PFKM rs11168417C > T, and PDK2 rs3785921G > A) were significantly associated with OS and/or DFS only in squamous cell carcinoma, whereas PFKP rs1132173C > T exhibited a significant association with survival outcomes only in adenocarcinoma. When the four SNPs were combined, OS and DFS decreased as the number of bad genotypes increased (Ptrend = 8 × 10 â '4 and 3 × 10 â '5, respectively). Promoter assays showed that ENO1 rs2274971G allele had significantly higher promoter activity compared to the rs2274971A allele. The four SNPs, especially ENO1 rs2274971A > G, may be useful for the prediction of prognosis in patients with surgically resected NSCLC.

Original language	English
Article number	35603
Journal	Scientific Reports
Volume	6
DOIs	https://doi.org/10.1038/srep35603
State	Published - 21 Oct 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/srep35603

Cite this

Lee, S. Y., Jin, C. C., Choi, J. E., Hong, M. J., Jung, D. K., Do, S. K., Baek, S. A., Kang, H. J., Kang, H. G., Choi, S. H., Lee, W. K., Seok, Y., Lee, E. B., Jeong, J. Y., Shin, K. M., Cho, S., Yoo, S. S., Lee, J., Cha, S. I., ... Park, J. Y. (2016). Genetic polymorphisms in glycolytic pathway are associated with the prognosis of patients with early stage non-small cell lung cancer. Scientific Reports, 6, Article 35603. https://doi.org/10.1038/srep35603

@article{b05c3a5772bd4a528dbdaa09300f847e,

title = "Genetic polymorphisms in glycolytic pathway are associated with the prognosis of patients with early stage non-small cell lung cancer",

abstract = "This study was conducted to investigate whether polymorphisms of genes involved in glycolysis are associated with the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Forty-four single nucleotide polymorphisms (SNPs) of 17 genes in glycolytic pathway were investigated in a total of 782 patients with NSCLC who underwent curative surgical resection. The association of the SNPs with overall survival (OS) and disease free survival (DFS) were analyzed. Among the 44 SNPs investigated, four SNPs (ENO1 rs2274971A > G, PFKM rs11168417C > T, PFKP rs1132173C > T, PDK2 rs3785921G > A) were significantly associated with survival outcomes in multivariate analyses. When stratified by tumor histology, three SNPs (ENO1 rs2274971A > G, PFKM rs11168417C > T, and PDK2 rs3785921G > A) were significantly associated with OS and/or DFS only in squamous cell carcinoma, whereas PFKP rs1132173C > T exhibited a significant association with survival outcomes only in adenocarcinoma. When the four SNPs were combined, OS and DFS decreased as the number of bad genotypes increased (Ptrend = 8 × 10 {\^a} '4 and 3 × 10 {\^a} '5, respectively). Promoter assays showed that ENO1 rs2274971G allele had significantly higher promoter activity compared to the rs2274971A allele. The four SNPs, especially ENO1 rs2274971A > G, may be useful for the prediction of prognosis in patients with surgically resected NSCLC.",

author = "Lee, {Shin Yup} and Jin, {Cheng Cheng} and Choi, {Jin Eun} and Hong, {Mi Jeong} and Jung, {Deuk Kju} and Do, {Sook Kyung} and Baek, {Sun Ah} and Kang, {Hyo Jung} and Kang, {Hyo Gyoung} and Choi, {Sun Ha} and Lee, {Won Kee} and Yangki Seok and Lee, {Eung Bae} and Jeong, {Ji Yun} and Shin, {Kyung Min} and Sukki Cho and Yoo, {Seung Soo} and Jaehee Lee and Cha, {Seung Ick} and Kim, {Chang Ho} and Lee, {You Mie} and Lee, {In Kyu} and Sanghoon Jheon and Park, {Jae Yong}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2016.",

year = "2016",

month = oct,

day = "21",

doi = "10.1038/srep35603",

language = "English",

volume = "6",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

}

Lee, SY, Jin, CC, Choi, JE, Hong, MJ, Jung, DK, Do, SK, Baek, SA, Kang, HJ, Kang, HG, Choi, SH, Lee, WK, Seok, Y, Lee, EB, Jeong, JY, Shin, KM, Cho, S, Yoo, SS, Lee, J, Cha, SI, Kim, CH, Lee, YM, Lee, IK, Jheon, S & Park, JY 2016, 'Genetic polymorphisms in glycolytic pathway are associated with the prognosis of patients with early stage non-small cell lung cancer', Scientific Reports, vol. 6, 35603. https://doi.org/10.1038/srep35603

TY - JOUR

T1 - Genetic polymorphisms in glycolytic pathway are associated with the prognosis of patients with early stage non-small cell lung cancer

AU - Lee, Shin Yup

AU - Jin, Cheng Cheng

AU - Choi, Jin Eun

AU - Hong, Mi Jeong

AU - Jung, Deuk Kju

AU - Do, Sook Kyung

AU - Baek, Sun Ah

AU - Kang, Hyo Jung

AU - Kang, Hyo Gyoung

AU - Choi, Sun Ha

AU - Lee, Won Kee

AU - Seok, Yangki

AU - Lee, Eung Bae

AU - Jeong, Ji Yun

AU - Shin, Kyung Min

AU - Cho, Sukki

AU - Yoo, Seung Soo

AU - Lee, Jaehee

AU - Cha, Seung Ick

AU - Kim, Chang Ho

AU - Lee, You Mie

AU - Lee, In Kyu

AU - Jheon, Sanghoon

AU - Park, Jae Yong

PY - 2016/10/21

Y1 - 2016/10/21

N2 - This study was conducted to investigate whether polymorphisms of genes involved in glycolysis are associated with the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Forty-four single nucleotide polymorphisms (SNPs) of 17 genes in glycolytic pathway were investigated in a total of 782 patients with NSCLC who underwent curative surgical resection. The association of the SNPs with overall survival (OS) and disease free survival (DFS) were analyzed. Among the 44 SNPs investigated, four SNPs (ENO1 rs2274971A > G, PFKM rs11168417C > T, PFKP rs1132173C > T, PDK2 rs3785921G > A) were significantly associated with survival outcomes in multivariate analyses. When stratified by tumor histology, three SNPs (ENO1 rs2274971A > G, PFKM rs11168417C > T, and PDK2 rs3785921G > A) were significantly associated with OS and/or DFS only in squamous cell carcinoma, whereas PFKP rs1132173C > T exhibited a significant association with survival outcomes only in adenocarcinoma. When the four SNPs were combined, OS and DFS decreased as the number of bad genotypes increased (Ptrend = 8 × 10 â '4 and 3 × 10 â '5, respectively). Promoter assays showed that ENO1 rs2274971G allele had significantly higher promoter activity compared to the rs2274971A allele. The four SNPs, especially ENO1 rs2274971A > G, may be useful for the prediction of prognosis in patients with surgically resected NSCLC.

AB - This study was conducted to investigate whether polymorphisms of genes involved in glycolysis are associated with the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Forty-four single nucleotide polymorphisms (SNPs) of 17 genes in glycolytic pathway were investigated in a total of 782 patients with NSCLC who underwent curative surgical resection. The association of the SNPs with overall survival (OS) and disease free survival (DFS) were analyzed. Among the 44 SNPs investigated, four SNPs (ENO1 rs2274971A > G, PFKM rs11168417C > T, PFKP rs1132173C > T, PDK2 rs3785921G > A) were significantly associated with survival outcomes in multivariate analyses. When stratified by tumor histology, three SNPs (ENO1 rs2274971A > G, PFKM rs11168417C > T, and PDK2 rs3785921G > A) were significantly associated with OS and/or DFS only in squamous cell carcinoma, whereas PFKP rs1132173C > T exhibited a significant association with survival outcomes only in adenocarcinoma. When the four SNPs were combined, OS and DFS decreased as the number of bad genotypes increased (Ptrend = 8 × 10 â '4 and 3 × 10 â '5, respectively). Promoter assays showed that ENO1 rs2274971G allele had significantly higher promoter activity compared to the rs2274971A allele. The four SNPs, especially ENO1 rs2274971A > G, may be useful for the prediction of prognosis in patients with surgically resected NSCLC.

UR - http://www.scopus.com/inward/record.url?scp=84992390675&partnerID=8YFLogxK

U2 - 10.1038/srep35603

DO - 10.1038/srep35603

M3 - Article

C2 - 27767175

AN - SCOPUS:84992390675

SN - 2045-2322

VL - 6

JO - Scientific Reports

JF - Scientific Reports

M1 - 35603

ER -

Genetic polymorphisms in glycolytic pathway are associated with the prognosis of patients with early stage non-small cell lung cancer

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this