Genetic polymorphisms of the bovine NOV gene are significantly associated with carcass traits in Korean cattle

B. S. Kim; S. C. Kim; C. M. Park; S. H. Lee; S. H. Cho; N. K. Kim; G. W. Jang; D. H. Yoon; B. S. Yang; S. K. Hong; H. H. Seong; B. H. Choi

doi:10.5713/ajas.2012.12514

Genetic polymorphisms of the bovine NOV gene are significantly associated with carcass traits in Korean cattle

B. S. Kim, S. C. Kim, C. M. Park, S. H. Lee, S. H. Cho, N. K. Kim, G. W. Jang, D. H. Yoon, B. S. Yang, S. K. Hong, H. H. Seong, B. H. Choi

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Abstract

The objective of this study was to investigate single nucleotide polymorphisms (SNPs) in the bovine nephroblastoma overexpressed (NOV) gene and to evaluate whether these polymorphisms affect carcass traits in the Korean cattle population. We resequenced to detect SNPs from 24 unrelated individuals and identified 19 SNPs within the full 8.4-kb gene, including the 1.5-kb promoter region. Of these 19 SNPs, four were selected for genotyping based on linkage disequilibrium (LD). We genotyped 429 steers to assess the associations of these four SNPs with carcass traits. Statistical analysis revealed that g.7801T>C and g.8379A>C polymorphisms in the NOV gene were associated with carcass weight (p = 0.012 and 0.008, respectively), and the g.2005A>G polymorphism was associated with the back fat thickness (BF) trait (p = 0.0001). One haplotype of the four SNPs (GGTA) was significantly associated with BF (p = 0.0005). Our findings suggest that polymorphisms in the NOV gene may be among the important genetic factors affecting carcass yield in beef cattle.

Original language	English
Pages (from-to)	780-787
Number of pages	8
Journal	Asian-Australasian Journal of Animal Sciences
Volume	26
Issue number	6
DOIs	https://doi.org/10.5713/ajas.2012.12514
State	Published - Jun 2013

Keywords

Back fat thickness
Carcass weight
Korean cattle
NOV gene
Single nucleotide polymorphism

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Kim, B. S., Kim, S. C., Park, C. M., Lee, S. H., Cho, S. H., Kim, N. K., Jang, G. W., Yoon, D. H., Yang, B. S., Hong, S. K., Seong, H. H., & Choi, B. H. (2013). Genetic polymorphisms of the bovine NOV gene are significantly associated with carcass traits in Korean cattle. Asian-Australasian Journal of Animal Sciences, 26(6), 780-787. https://doi.org/10.5713/ajas.2012.12514

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title = "Genetic polymorphisms of the bovine NOV gene are significantly associated with carcass traits in Korean cattle",

abstract = "The objective of this study was to investigate single nucleotide polymorphisms (SNPs) in the bovine nephroblastoma overexpressed (NOV) gene and to evaluate whether these polymorphisms affect carcass traits in the Korean cattle population. We resequenced to detect SNPs from 24 unrelated individuals and identified 19 SNPs within the full 8.4-kb gene, including the 1.5-kb promoter region. Of these 19 SNPs, four were selected for genotyping based on linkage disequilibrium (LD). We genotyped 429 steers to assess the associations of these four SNPs with carcass traits. Statistical analysis revealed that g.7801T>C and g.8379A>C polymorphisms in the NOV gene were associated with carcass weight (p = 0.012 and 0.008, respectively), and the g.2005A>G polymorphism was associated with the back fat thickness (BF) trait (p = 0.0001). One haplotype of the four SNPs (GGTA) was significantly associated with BF (p = 0.0005). Our findings suggest that polymorphisms in the NOV gene may be among the important genetic factors affecting carcass yield in beef cattle.",

keywords = "Back fat thickness, Carcass weight, Korean cattle, NOV gene, Single nucleotide polymorphism",

author = "Kim, {B. S.} and Kim, {S. C.} and Park, {C. M.} and Lee, {S. H.} and Cho, {S. H.} and Kim, {N. K.} and Jang, {G. W.} and Yoon, {D. H.} and Yang, {B. S.} and Hong, {S. K.} and Seong, {H. H.} and Choi, {B. H.}",

year = "2013",

month = jun,

doi = "10.5713/ajas.2012.12514",

language = "English",

volume = "26",

pages = "780--787",

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publisher = "Asian-Australasian Association of Animal Production Societies",

number = "6",

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AU - Kim, B. S.

AU - Kim, S. C.

AU - Park, C. M.

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AU - Cho, S. H.

AU - Kim, N. K.

AU - Jang, G. W.

AU - Yoon, D. H.

AU - Yang, B. S.

AU - Hong, S. K.

AU - Seong, H. H.

AU - Choi, B. H.

PY - 2013/6

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N2 - The objective of this study was to investigate single nucleotide polymorphisms (SNPs) in the bovine nephroblastoma overexpressed (NOV) gene and to evaluate whether these polymorphisms affect carcass traits in the Korean cattle population. We resequenced to detect SNPs from 24 unrelated individuals and identified 19 SNPs within the full 8.4-kb gene, including the 1.5-kb promoter region. Of these 19 SNPs, four were selected for genotyping based on linkage disequilibrium (LD). We genotyped 429 steers to assess the associations of these four SNPs with carcass traits. Statistical analysis revealed that g.7801T>C and g.8379A>C polymorphisms in the NOV gene were associated with carcass weight (p = 0.012 and 0.008, respectively), and the g.2005A>G polymorphism was associated with the back fat thickness (BF) trait (p = 0.0001). One haplotype of the four SNPs (GGTA) was significantly associated with BF (p = 0.0005). Our findings suggest that polymorphisms in the NOV gene may be among the important genetic factors affecting carcass yield in beef cattle.

AB - The objective of this study was to investigate single nucleotide polymorphisms (SNPs) in the bovine nephroblastoma overexpressed (NOV) gene and to evaluate whether these polymorphisms affect carcass traits in the Korean cattle population. We resequenced to detect SNPs from 24 unrelated individuals and identified 19 SNPs within the full 8.4-kb gene, including the 1.5-kb promoter region. Of these 19 SNPs, four were selected for genotyping based on linkage disequilibrium (LD). We genotyped 429 steers to assess the associations of these four SNPs with carcass traits. Statistical analysis revealed that g.7801T>C and g.8379A>C polymorphisms in the NOV gene were associated with carcass weight (p = 0.012 and 0.008, respectively), and the g.2005A>G polymorphism was associated with the back fat thickness (BF) trait (p = 0.0001). One haplotype of the four SNPs (GGTA) was significantly associated with BF (p = 0.0005). Our findings suggest that polymorphisms in the NOV gene may be among the important genetic factors affecting carcass yield in beef cattle.

KW - Back fat thickness

KW - Carcass weight

KW - Korean cattle

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KW - Single nucleotide polymorphism

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Genetic polymorphisms of the bovine NOV gene are significantly associated with carcass traits in Korean cattle

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Keywords

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