Genomic characterization and probiotic potential of Lactobacillus casei IDCC 3451 isolated from infant faeces

M. Shin; O. H. Ban; Y. H. Jung; J. Yang; Y. Kim

doi:10.1111/lam.13449

Genomic characterization and probiotic potential of Lactobacillus casei IDCC 3451 isolated from infant faeces

M. Shin
, O. H. Ban
, Y. H. Jung
, J. Yang
, Y. Kim

Seoul National University
Ildong Bioscience

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Probiotics play an important role in health benefits on the host. However, they also possess potentials for infectivity or in situ toxin production; thus, requiring a comprehensive assessment of their safety. In this study, we report genomic characteristics of a newly isolated Lactobacillus casei IDCC 3451 from infant faeces. Phenotypic assays based on enzyme activities and carbohydrate fermentation profiles represented metabolic features of the strain. Safety evaluation for antimicrobial resistance, biogenic amines production and cytotoxicity to a murine mouse model suggested its safe use as a probiotic strain. Our findings on the genetic background of L. casei IDCC 3451 and its potential features provide a promising functional and safe probiotic strain for the human consumption.

Original language	English
Pages (from-to)	578-588
Number of pages	11
Journal	Letters in Applied Microbiology
Volume	72
Issue number	5
DOIs	https://doi.org/10.1111/lam.13449
State	Published - May 2021

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

probiotics
safety assessment
whole genome sequencing

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10.1111/lam.13449

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abstract = "Probiotics play an important role in health benefits on the host. However, they also possess potentials for infectivity or in situ toxin production; thus, requiring a comprehensive assessment of their safety. In this study, we report genomic characteristics of a newly isolated Lactobacillus casei IDCC 3451 from infant faeces. Phenotypic assays based on enzyme activities and carbohydrate fermentation profiles represented metabolic features of the strain. Safety evaluation for antimicrobial resistance, biogenic amines production and cytotoxicity to a murine mouse model suggested its safe use as a probiotic strain. Our findings on the genetic background of L. casei IDCC 3451 and its potential features provide a promising functional and safe probiotic strain for the human consumption.",

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AU - Shin, M.

AU - Ban, O. H.

AU - Jung, Y. H.

AU - Yang, J.

AU - Kim, Y.

PY - 2021/5

Y1 - 2021/5

N2 - Probiotics play an important role in health benefits on the host. However, they also possess potentials for infectivity or in situ toxin production; thus, requiring a comprehensive assessment of their safety. In this study, we report genomic characteristics of a newly isolated Lactobacillus casei IDCC 3451 from infant faeces. Phenotypic assays based on enzyme activities and carbohydrate fermentation profiles represented metabolic features of the strain. Safety evaluation for antimicrobial resistance, biogenic amines production and cytotoxicity to a murine mouse model suggested its safe use as a probiotic strain. Our findings on the genetic background of L. casei IDCC 3451 and its potential features provide a promising functional and safe probiotic strain for the human consumption.

AB - Probiotics play an important role in health benefits on the host. However, they also possess potentials for infectivity or in situ toxin production; thus, requiring a comprehensive assessment of their safety. In this study, we report genomic characteristics of a newly isolated Lactobacillus casei IDCC 3451 from infant faeces. Phenotypic assays based on enzyme activities and carbohydrate fermentation profiles represented metabolic features of the strain. Safety evaluation for antimicrobial resistance, biogenic amines production and cytotoxicity to a murine mouse model suggested its safe use as a probiotic strain. Our findings on the genetic background of L. casei IDCC 3451 and its potential features provide a promising functional and safe probiotic strain for the human consumption.

KW - probiotics

KW - safety assessment

KW - whole genome sequencing

UR - https://www.scopus.com/pages/publications/85100701400

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AN - SCOPUS:85100701400

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VL - 72

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JO - Letters in Applied Microbiology

JF - Letters in Applied Microbiology

IS - 5

ER -

Genomic characterization and probiotic potential of Lactobacillus casei IDCC 3451 isolated from infant faeces

Abstract

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Keywords

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