Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells

Ji Sue Baik; You Na Seo; Joo Mi Yi; Man Hee Rhee; Moon Taek Park; Sung Dae Kim

doi:10.1016/j.jgr.2020.01.006

Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells

Ji Sue Baik
, You Na Seo
, Joo Mi Yi
, Man Hee Rhee
, Moon Taek Park
, Sung Dae Kim

Dongnam Inst. of Radiological and Medical Sciences
Inje University

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

This study investigated the inhibitory effect of ginsenoside-Rp1 (G-Rp1) on the ionizing radiation (IR)-induced response in lipopolysaccharide (LPS)-stimulated macrophages and its effects on the malignancy of tumor cells. G-Rp1 inhibited the activation of IR-induced DNA damage-related signaling molecules and thereby interfered with the IR-increased production of nitric oxide (NO) and interleukin (IL)-1β. The inhibitory effect of G-Rp1 increased the survival rate of mice inoculated with CT26 colon cancer cells by suppressing the phenotypic variation of tumor cells induced by conditioned medium obtained from IR- and LPS-treated J774A.1 macrophages.

Original language	English
Pages (from-to)	843-848
Number of pages	6
Journal	Journal of Ginseng Research
Volume	44
Issue number	6
DOIs	https://doi.org/10.1016/j.jgr.2020.01.006
State	Published - Nov 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer
Ginsenoside-Rp1
Macrophages
Panax ginseng
Radiation

Access to Document

10.1016/j.jgr.2020.01.006

Cite this

@article{d221c202834d4505a415c82760ef2b3b,

title = "Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells",

abstract = "This study investigated the inhibitory effect of ginsenoside-Rp1 (G-Rp1) on the ionizing radiation (IR)-induced response in lipopolysaccharide (LPS)-stimulated macrophages and its effects on the malignancy of tumor cells. G-Rp1 inhibited the activation of IR-induced DNA damage-related signaling molecules and thereby interfered with the IR-increased production of nitric oxide (NO) and interleukin (IL)-1β. The inhibitory effect of G-Rp1 increased the survival rate of mice inoculated with CT26 colon cancer cells by suppressing the phenotypic variation of tumor cells induced by conditioned medium obtained from IR- and LPS-treated J774A.1 macrophages.",

keywords = "Cancer, Ginsenoside-Rp1, Macrophages, Panax ginseng, Radiation",

author = "Baik, \{Ji Sue\} and Seo, \{You Na\} and Yi, \{Joo Mi\} and Rhee, \{Man Hee\} and Park, \{Moon Taek\} and Kim, \{Sung Dae\}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = nov,

doi = "10.1016/j.jgr.2020.01.006",

language = "English",

volume = "44",

pages = "843--848",

journal = "Journal of Ginseng Research",

issn = "1226-8453",

publisher = "Elsevier B.V.",

number = "6",

}

TY - JOUR

T1 - Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells

AU - Baik, Ji Sue

AU - Seo, You Na

AU - Yi, Joo Mi

AU - Rhee, Man Hee

AU - Park, Moon Taek

AU - Kim, Sung Dae

PY - 2020/11

Y1 - 2020/11

N2 - This study investigated the inhibitory effect of ginsenoside-Rp1 (G-Rp1) on the ionizing radiation (IR)-induced response in lipopolysaccharide (LPS)-stimulated macrophages and its effects on the malignancy of tumor cells. G-Rp1 inhibited the activation of IR-induced DNA damage-related signaling molecules and thereby interfered with the IR-increased production of nitric oxide (NO) and interleukin (IL)-1β. The inhibitory effect of G-Rp1 increased the survival rate of mice inoculated with CT26 colon cancer cells by suppressing the phenotypic variation of tumor cells induced by conditioned medium obtained from IR- and LPS-treated J774A.1 macrophages.

AB - This study investigated the inhibitory effect of ginsenoside-Rp1 (G-Rp1) on the ionizing radiation (IR)-induced response in lipopolysaccharide (LPS)-stimulated macrophages and its effects on the malignancy of tumor cells. G-Rp1 inhibited the activation of IR-induced DNA damage-related signaling molecules and thereby interfered with the IR-increased production of nitric oxide (NO) and interleukin (IL)-1β. The inhibitory effect of G-Rp1 increased the survival rate of mice inoculated with CT26 colon cancer cells by suppressing the phenotypic variation of tumor cells induced by conditioned medium obtained from IR- and LPS-treated J774A.1 macrophages.

KW - Cancer

KW - Ginsenoside-Rp1

KW - Macrophages

KW - Panax ginseng

KW - Radiation

UR - https://www.scopus.com/pages/publications/85080124272

U2 - 10.1016/j.jgr.2020.01.006

DO - 10.1016/j.jgr.2020.01.006

M3 - Article

AN - SCOPUS:85080124272

SN - 1226-8453

VL - 44

SP - 843

EP - 848

JO - Journal of Ginseng Research

JF - Journal of Ginseng Research

IS - 6

ER -

Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this