Glucose Transporter 1 Gene Variants Predict the Prognosis of Patients with Early-Stage Non-small Cell Lung Cancer

Sook Kyung Do; Ji Yun Jeong; Shin Yup Lee; Jin Eun Choi; Mi Jeong Hong; Hyo Gyoung Kang; Won Kee Lee; Yangki Seok; Eung Bae Lee; Kyung Min Shin; Seung Soo Yoo; Jaehee Lee; Seung Ick Cha; Chang Ho Kim; Michael L. Neugent; Justin Goodwin; Jung whan Kim; Jae Yong Park

doi:10.1245/s10434-018-6677-1

Glucose Transporter 1 Gene Variants Predict the Prognosis of Patients with Early-Stage Non-small Cell Lung Cancer

Sook Kyung Do, Ji Yun Jeong, Shin Yup Lee, Jin Eun Choi, Mi Jeong Hong, Hyo Gyoung Kang, Won Kee Lee, Yangki Seok, Eung Bae Lee, Kyung Min Shin, Seung Soo Yoo, Jaehee Lee, Seung Ick Cha, Chang Ho Kim, Michael L. Neugent, Justin Goodwin, Jung whan Kim, Jae Yong Park

Department of Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background: This study was conducted to investigate whether polymorphisms of glucose transporter 1 (GLUT1) gene are associated with the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Methods: Five single nucleotide polymorphisms (SNPs) in GLUT1 were investigated in a total of 354 patients with NSCLC who underwent curative surgery. The association of the SNPs with patients’ survival was analyzed. Results: Among the five SNPs investigated, two SNPs (GLUT1 rs3820589T > A and rs4658G > C) were significantly associated with OS in multivariate analyses. GLUT1 rs3820589T > A was associated with significantly better OS (adjusted hazard ratio [aHR] = 0.57, 95% confidence interval [CI] = 0.34–0.94, P = 0.03, under dominant model), and rs4658G > C was associated with significantly worse OS (aHR = 1.91, 95% CI = 1.09–3.33, P = 0.02, under recessive model). In the stratified analysis by tumor histology, the effect of these SNPs on OS was only significant in squamous cell carcinoma but not in adenocarcinoma. When the two SNPs were combined, OS decreased as the number of bad genotypes increased (Ptrend = 4 × 10⁻³). Conclusions: This study suggests that genetic variation in GLUT1 may be useful in predicting survival of patients with early stage NSCLC.

Original language	English
Pages (from-to)	3396-3403
Number of pages	8
Journal	Annals of Surgical Oncology
Volume	25
Issue number	11
DOIs	https://doi.org/10.1245/s10434-018-6677-1
State	Published - 1 Oct 2018

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Do, S. K., Jeong, J. Y., Lee, S. Y., Choi, J. E., Hong, M. J., Kang, H. G., Lee, W. K., Seok, Y., Lee, E. B., Shin, K. M., Yoo, S. S., Lee, J., Cha, S. I., Kim, C. H., Neugent, M. L., Goodwin, J., Kim, J. W., & Park, J. Y. (2018). Glucose Transporter 1 Gene Variants Predict the Prognosis of Patients with Early-Stage Non-small Cell Lung Cancer. Annals of Surgical Oncology, 25(11), 3396-3403. https://doi.org/10.1245/s10434-018-6677-1

@article{221f53d3da0c494dad397b1d30adecbe,

title = "Glucose Transporter 1 Gene Variants Predict the Prognosis of Patients with Early-Stage Non-small Cell Lung Cancer",

abstract = "Background: This study was conducted to investigate whether polymorphisms of glucose transporter 1 (GLUT1) gene are associated with the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Methods: Five single nucleotide polymorphisms (SNPs) in GLUT1 were investigated in a total of 354 patients with NSCLC who underwent curative surgery. The association of the SNPs with patients{\textquoteright} survival was analyzed. Results: Among the five SNPs investigated, two SNPs (GLUT1 rs3820589T > A and rs4658G > C) were significantly associated with OS in multivariate analyses. GLUT1 rs3820589T > A was associated with significantly better OS (adjusted hazard ratio [aHR] = 0.57, 95% confidence interval [CI] = 0.34–0.94, P = 0.03, under dominant model), and rs4658G > C was associated with significantly worse OS (aHR = 1.91, 95% CI = 1.09–3.33, P = 0.02, under recessive model). In the stratified analysis by tumor histology, the effect of these SNPs on OS was only significant in squamous cell carcinoma but not in adenocarcinoma. When the two SNPs were combined, OS decreased as the number of bad genotypes increased (Ptrend = 4 × 10−3). Conclusions: This study suggests that genetic variation in GLUT1 may be useful in predicting survival of patients with early stage NSCLC.",

author = "Do, {Sook Kyung} and Jeong, {Ji Yun} and Lee, {Shin Yup} and Choi, {Jin Eun} and Hong, {Mi Jeong} and Kang, {Hyo Gyoung} and Lee, {Won Kee} and Yangki Seok and Lee, {Eung Bae} and Shin, {Kyung Min} and Yoo, {Seung Soo} and Jaehee Lee and Cha, {Seung Ick} and Kim, {Chang Ho} and Neugent, {Michael L.} and Justin Goodwin and Kim, {Jung whan} and Park, {Jae Yong}",

note = "Publisher Copyright: {\textcopyright} 2018, Society of Surgical Oncology.",

year = "2018",

month = oct,

day = "1",

doi = "10.1245/s10434-018-6677-1",

language = "English",

volume = "25",

pages = "3396--3403",

journal = "Annals of Surgical Oncology",

issn = "1068-9265",

publisher = "Springer New York",

number = "11",

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Do, SK, Jeong, JY, Lee, SY, Choi, JE, Hong, MJ, Kang, HG, Lee, WK, Seok, Y, Lee, EB, Shin, KM, Yoo, SS, Lee, J, Cha, SI, Kim, CH, Neugent, ML, Goodwin, J, Kim, JW & Park, JY 2018, 'Glucose Transporter 1 Gene Variants Predict the Prognosis of Patients with Early-Stage Non-small Cell Lung Cancer', Annals of Surgical Oncology, vol. 25, no. 11, pp. 3396-3403. https://doi.org/10.1245/s10434-018-6677-1

TY - JOUR

T1 - Glucose Transporter 1 Gene Variants Predict the Prognosis of Patients with Early-Stage Non-small Cell Lung Cancer

AU - Do, Sook Kyung

AU - Jeong, Ji Yun

AU - Lee, Shin Yup

AU - Choi, Jin Eun

AU - Hong, Mi Jeong

AU - Kang, Hyo Gyoung

AU - Lee, Won Kee

AU - Seok, Yangki

AU - Lee, Eung Bae

AU - Shin, Kyung Min

AU - Yoo, Seung Soo

AU - Lee, Jaehee

AU - Cha, Seung Ick

AU - Kim, Chang Ho

AU - Neugent, Michael L.

AU - Goodwin, Justin

AU - Kim, Jung whan

AU - Park, Jae Yong

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Background: This study was conducted to investigate whether polymorphisms of glucose transporter 1 (GLUT1) gene are associated with the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Methods: Five single nucleotide polymorphisms (SNPs) in GLUT1 were investigated in a total of 354 patients with NSCLC who underwent curative surgery. The association of the SNPs with patients’ survival was analyzed. Results: Among the five SNPs investigated, two SNPs (GLUT1 rs3820589T > A and rs4658G > C) were significantly associated with OS in multivariate analyses. GLUT1 rs3820589T > A was associated with significantly better OS (adjusted hazard ratio [aHR] = 0.57, 95% confidence interval [CI] = 0.34–0.94, P = 0.03, under dominant model), and rs4658G > C was associated with significantly worse OS (aHR = 1.91, 95% CI = 1.09–3.33, P = 0.02, under recessive model). In the stratified analysis by tumor histology, the effect of these SNPs on OS was only significant in squamous cell carcinoma but not in adenocarcinoma. When the two SNPs were combined, OS decreased as the number of bad genotypes increased (Ptrend = 4 × 10−3). Conclusions: This study suggests that genetic variation in GLUT1 may be useful in predicting survival of patients with early stage NSCLC.

AB - Background: This study was conducted to investigate whether polymorphisms of glucose transporter 1 (GLUT1) gene are associated with the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection. Methods: Five single nucleotide polymorphisms (SNPs) in GLUT1 were investigated in a total of 354 patients with NSCLC who underwent curative surgery. The association of the SNPs with patients’ survival was analyzed. Results: Among the five SNPs investigated, two SNPs (GLUT1 rs3820589T > A and rs4658G > C) were significantly associated with OS in multivariate analyses. GLUT1 rs3820589T > A was associated with significantly better OS (adjusted hazard ratio [aHR] = 0.57, 95% confidence interval [CI] = 0.34–0.94, P = 0.03, under dominant model), and rs4658G > C was associated with significantly worse OS (aHR = 1.91, 95% CI = 1.09–3.33, P = 0.02, under recessive model). In the stratified analysis by tumor histology, the effect of these SNPs on OS was only significant in squamous cell carcinoma but not in adenocarcinoma. When the two SNPs were combined, OS decreased as the number of bad genotypes increased (Ptrend = 4 × 10−3). Conclusions: This study suggests that genetic variation in GLUT1 may be useful in predicting survival of patients with early stage NSCLC.

UR - http://www.scopus.com/inward/record.url?scp=85050974657&partnerID=8YFLogxK

U2 - 10.1245/s10434-018-6677-1

DO - 10.1245/s10434-018-6677-1

M3 - Article

C2 - 30062472

AN - SCOPUS:85050974657

SN - 1068-9265

VL - 25

SP - 3396

EP - 3403

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

IS - 11

ER -

Glucose Transporter 1 Gene Variants Predict the Prognosis of Patients with Early-Stage Non-small Cell Lung Cancer

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