Glyceollins protection against vascular endothelial cell death caused by a low-dose proton beam

Myung Hwan Jung, Saeng Myung Han, Sun Hee Lee, You Mie Lee, Yong Hoon Kim

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

In space, radiation is known to induce oxidative stress in astronauts after extended space flight. During space travel, astronauts are exposed to radiations, such as protons and high-atomic numbers, high-energy particles. Glyceollins are a novel class of soybean phytoalexin with potential cancer-preventive effects. In this study, we evaluated proton-generated oxidative stress and the protective effect of glyceollins extracted from soybean on the oxidative stress generated by proton stress in vascular endothelial cells in vitro. The results demonstrated that exposure to a proton beam (35 MeV) significantly induced cell death at low doses (0.1 - 1 Gy), but glyceollins inhibited proton-induced cell death in human umbilical vein endothelial cells (HUVECs). The proton beam increased reactive oxygen species (ROS), as measured by using an oxidant-sensitive fluorescent probe, DCFH-DA and glyceollins inhibited proton-induced ROS generation in HUVECs. These findings suggest that biological damage caused by exposure to space radiation, such as a proton beam, may be prevented, at least partially, by dietary supplementation with agents expected to have protective effects on the oxidative stress.

Original languageEnglish
Pages (from-to)2129-2132
Number of pages4
JournalJournal of the Korean Physical Society
Volume54
Issue number5 PART 2
DOIs
StatePublished - May 2009

Keywords

  • Glyceollins
  • HUVEC
  • Oxidative stress
  • Protective effect
  • Proton

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