Gold nanoparticles functionalised by Gd-complex of DTPA-bis(amide) conjugate of glutathione as an MRI contrast agent

Ji Ae Park; Pattubala A.N. Reddy; Hee Kyung Kim; In Sung Kim; Gab Chul Kim; Yongmin Chang; Tae Jeong Kim

doi:10.1016/j.bmcl.2008.10.017

Gold nanoparticles functionalised by Gd-complex of DTPA-bis(amide) conjugate of glutathione as an MRI contrast agent

Ji Ae Park, Pattubala A.N. Reddy, Hee Kyung Kim, In Sung Kim, Gab Chul Kim, Yongmin Chang, Tae Jeong Kim

Department of Medicine

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

The work is directed toward the synthesis of gold nanoparticles (Au NPs) coated with paramagnetic Gd-complex of DTPA-bis(amide) conjugate of glutathione (GdL) for use as a highly efficient MRI contrast agent. Well-dispersed spherical Au NPs coated with gadolinium complexes, abbreviated as Au@GdL, have been obtained; the mean size of Au@GdL is 5-7 nm, and the numbers of GdL are 1.36 × 10⁴ per Au NP. Au@GdL exhibits high longitudinal (r1) and transverse (r2) relaxivities of 1.87 × 10⁵ and 3.02 × 10⁵ mM^-1 s^-1, respectively.

Original language	English
Pages (from-to)	6135-6137
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	18
Issue number	23
DOIs	https://doi.org/10.1016/j.bmcl.2008.10.017
State	Published - 1 Dec 2008

Keywords

DTPA-bis(amide)
Gd-complex
Glutathione
Gold nanoparticles
Relaxivity

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10.1016/j.bmcl.2008.10.017

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title = "Gold nanoparticles functionalised by Gd-complex of DTPA-bis(amide) conjugate of glutathione as an MRI contrast agent",

abstract = "The work is directed toward the synthesis of gold nanoparticles (Au NPs) coated with paramagnetic Gd-complex of DTPA-bis(amide) conjugate of glutathione (GdL) for use as a highly efficient MRI contrast agent. Well-dispersed spherical Au NPs coated with gadolinium complexes, abbreviated as Au@GdL, have been obtained; the mean size of Au@GdL is 5-7 nm, and the numbers of GdL are 1.36 × 104 per Au NP. Au@GdL exhibits high longitudinal (r1) and transverse (r2) relaxivities of 1.87 × 105 and 3.02 × 105 mM-1 s-1, respectively.",

keywords = "DTPA-bis(amide), Gd-complex, Glutathione, Gold nanoparticles, Relaxivity",

author = "Park, {Ji Ae} and Reddy, {Pattubala A.N.} and Kim, {Hee Kyung} and Kim, {In Sung} and Kim, {Gab Chul} and Yongmin Chang and Kim, {Tae Jeong}",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Gold nanoparticles functionalised by Gd-complex of DTPA-bis(amide) conjugate of glutathione as an MRI contrast agent

AU - Park, Ji Ae

AU - Reddy, Pattubala A.N.

AU - Kim, Hee Kyung

AU - Kim, In Sung

AU - Kim, Gab Chul

AU - Chang, Yongmin

AU - Kim, Tae Jeong

PY - 2008/12/1

Y1 - 2008/12/1

N2 - The work is directed toward the synthesis of gold nanoparticles (Au NPs) coated with paramagnetic Gd-complex of DTPA-bis(amide) conjugate of glutathione (GdL) for use as a highly efficient MRI contrast agent. Well-dispersed spherical Au NPs coated with gadolinium complexes, abbreviated as Au@GdL, have been obtained; the mean size of Au@GdL is 5-7 nm, and the numbers of GdL are 1.36 × 104 per Au NP. Au@GdL exhibits high longitudinal (r1) and transverse (r2) relaxivities of 1.87 × 105 and 3.02 × 105 mM-1 s-1, respectively.

AB - The work is directed toward the synthesis of gold nanoparticles (Au NPs) coated with paramagnetic Gd-complex of DTPA-bis(amide) conjugate of glutathione (GdL) for use as a highly efficient MRI contrast agent. Well-dispersed spherical Au NPs coated with gadolinium complexes, abbreviated as Au@GdL, have been obtained; the mean size of Au@GdL is 5-7 nm, and the numbers of GdL are 1.36 × 104 per Au NP. Au@GdL exhibits high longitudinal (r1) and transverse (r2) relaxivities of 1.87 × 105 and 3.02 × 105 mM-1 s-1, respectively.

KW - DTPA-bis(amide)

KW - Gd-complex

KW - Glutathione

KW - Gold nanoparticles

KW - Relaxivity

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Gold nanoparticles functionalised by Gd-complex of DTPA-bis(amide) conjugate of glutathione as an MRI contrast agent

Abstract

Keywords

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