Gold nanoparticles functionalised by Gd-complex of DTPA-bis(amide) conjugate of glutathione as an MRI contrast agent

Ji Ae Park; Pattubala A.N. Reddy; Hee Kyung Kim; In Sung Kim; Gab Chul Kim; Yongmin Chang; Tae Jeong Kim

doi:10.1016/j.bmcl.2008.10.017

Gold nanoparticles functionalised by Gd-complex of DTPA-bis(amide) conjugate of glutathione as an MRI contrast agent

Ji Ae Park
, Pattubala A.N. Reddy
, Hee Kyung Kim
, In Sung Kim
, Gab Chul Kim
, Yongmin Chang
, Tae Jeong Kim

Department of Medicine

Kyungpook National University

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

The work is directed toward the synthesis of gold nanoparticles (Au NPs) coated with paramagnetic Gd-complex of DTPA-bis(amide) conjugate of glutathione (GdL) for use as a highly efficient MRI contrast agent. Well-dispersed spherical Au NPs coated with gadolinium complexes, abbreviated as Au@GdL, have been obtained; the mean size of Au@GdL is 5-7 nm, and the numbers of GdL are 1.36 × 10⁴ per Au NP. Au@GdL exhibits high longitudinal (r1) and transverse (r2) relaxivities of 1.87 × 10⁵ and 3.02 × 10⁵ mM^-1 s^-1, respectively.

Original language	English
Pages (from-to)	6135-6137
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	18
Issue number	23
DOIs	https://doi.org/10.1016/j.bmcl.2008.10.017
State	Published - 1 Dec 2008

Keywords

DTPA-bis(amide)
Gd-complex
Glutathione
Gold nanoparticles
Relaxivity

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10.1016/j.bmcl.2008.10.017

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title = "Gold nanoparticles functionalised by Gd-complex of DTPA-bis(amide) conjugate of glutathione as an MRI contrast agent",

abstract = "The work is directed toward the synthesis of gold nanoparticles (Au NPs) coated with paramagnetic Gd-complex of DTPA-bis(amide) conjugate of glutathione (GdL) for use as a highly efficient MRI contrast agent. Well-dispersed spherical Au NPs coated with gadolinium complexes, abbreviated as Au@GdL, have been obtained; the mean size of Au@GdL is 5-7 nm, and the numbers of GdL are 1.36 × 104 per Au NP. Au@GdL exhibits high longitudinal (r1) and transverse (r2) relaxivities of 1.87 × 105 and 3.02 × 105 mM-1 s-1, respectively.",

keywords = "DTPA-bis(amide), Gd-complex, Glutathione, Gold nanoparticles, Relaxivity",

author = "Park, \{Ji Ae\} and Reddy, \{Pattubala A.N.\} and Kim, \{Hee Kyung\} and Kim, \{In Sung\} and Kim, \{Gab Chul\} and Yongmin Chang and Kim, \{Tae Jeong\}",

year = "2008",

month = dec,

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doi = "10.1016/j.bmcl.2008.10.017",

language = "English",

volume = "18",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Gold nanoparticles functionalised by Gd-complex of DTPA-bis(amide) conjugate of glutathione as an MRI contrast agent

AU - Park, Ji Ae

AU - Reddy, Pattubala A.N.

AU - Kim, Hee Kyung

AU - Kim, In Sung

AU - Kim, Gab Chul

AU - Chang, Yongmin

AU - Kim, Tae Jeong

PY - 2008/12/1

Y1 - 2008/12/1

N2 - The work is directed toward the synthesis of gold nanoparticles (Au NPs) coated with paramagnetic Gd-complex of DTPA-bis(amide) conjugate of glutathione (GdL) for use as a highly efficient MRI contrast agent. Well-dispersed spherical Au NPs coated with gadolinium complexes, abbreviated as Au@GdL, have been obtained; the mean size of Au@GdL is 5-7 nm, and the numbers of GdL are 1.36 × 104 per Au NP. Au@GdL exhibits high longitudinal (r1) and transverse (r2) relaxivities of 1.87 × 105 and 3.02 × 105 mM-1 s-1, respectively.

AB - The work is directed toward the synthesis of gold nanoparticles (Au NPs) coated with paramagnetic Gd-complex of DTPA-bis(amide) conjugate of glutathione (GdL) for use as a highly efficient MRI contrast agent. Well-dispersed spherical Au NPs coated with gadolinium complexes, abbreviated as Au@GdL, have been obtained; the mean size of Au@GdL is 5-7 nm, and the numbers of GdL are 1.36 × 104 per Au NP. Au@GdL exhibits high longitudinal (r1) and transverse (r2) relaxivities of 1.87 × 105 and 3.02 × 105 mM-1 s-1, respectively.

KW - DTPA-bis(amide)

KW - Gd-complex

KW - Glutathione

KW - Gold nanoparticles

KW - Relaxivity

UR - https://www.scopus.com/pages/publications/55549111554

U2 - 10.1016/j.bmcl.2008.10.017

DO - 10.1016/j.bmcl.2008.10.017

M3 - Article

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AN - SCOPUS:55549111554

SN - 0960-894X

VL - 18

SP - 6135

EP - 6137

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 23

ER -

Gold nanoparticles functionalised by Gd-complex of DTPA-bis(amide) conjugate of glutathione as an MRI contrast agent

Abstract

Keywords

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