Gold nanoparticles functionalized by gadolinium-DTPA conjugate of cysteine as a multimodal bioimaging agent

Ji Ae Park; Hee Kyung Kim; Joo Hyun Kim; Sang Won Jeong; Jae Chang Jung; Gang Ho Lee; Jongmin Lee; Yongmin Chang; Tae Jeong Kim

doi:10.1016/j.bmcl.2010.02.002

Gold nanoparticles functionalized by gadolinium-DTPA conjugate of cysteine as a multimodal bioimaging agent

Ji Ae Park
, Hee Kyung Kim
, Joo Hyun Kim
, Sang Won Jeong
, Jae Chang Jung
, Gang Ho Lee
, Jongmin Lee
, Yongmin Chang
, Tae Jeong Kim

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

The synthesis and characterization of gold nanoparticles coated with Gd-chelate (Au@GdL), where L is a conjugate of DTPA and cysteine, is described. These particles are obtained by the replacement of citrate from the gold nanoparticle surfaces with gadolinium chelate (GdL). The average size of Au@GdL is 14 nm with a loading of GdL reaching up to 2.9 × 10³ per particles, and they demonstrate very high R1 relaxivity (∼10⁵ mM^-1 s^-1) as well as X-ray attenuation. The R1 relaxivity per [Gd] is 17.9 mM^-1 s^-1. The present system also exhibits macrophage-specific property, as demonstrated by histological and TEM images as well as CT and MR, rendering itself as a new class of T1 multimodal CT/MR contrast agent.

Original language	English
Pages (from-to)	2287-2291
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	7
DOIs	https://doi.org/10.1016/j.bmcl.2010.02.002
State	Published - 1 Apr 2010

Keywords

DTPA-cysteine
Gadolinium chelate
Gold nanoparticles
MRI-CT bimodality
T1 agent

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10.1016/j.bmcl.2010.02.002

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@article{2648fee1646b4cb3b7547cafc2e512bd,

title = "Gold nanoparticles functionalized by gadolinium-DTPA conjugate of cysteine as a multimodal bioimaging agent",

abstract = "The synthesis and characterization of gold nanoparticles coated with Gd-chelate (Au@GdL), where L is a conjugate of DTPA and cysteine, is described. These particles are obtained by the replacement of citrate from the gold nanoparticle surfaces with gadolinium chelate (GdL). The average size of Au@GdL is 14 nm with a loading of GdL reaching up to 2.9 × 103 per particles, and they demonstrate very high R1 relaxivity (∼105 mM-1 s-1) as well as X-ray attenuation. The R1 relaxivity per [Gd] is 17.9 mM-1 s-1. The present system also exhibits macrophage-specific property, as demonstrated by histological and TEM images as well as CT and MR, rendering itself as a new class of T1 multimodal CT/MR contrast agent.",

keywords = "DTPA-cysteine, Gadolinium chelate, Gold nanoparticles, MRI-CT bimodality, T1 agent",

author = "Park, \{Ji Ae\} and Kim, \{Hee Kyung\} and Kim, \{Joo Hyun\} and Jeong, \{Sang Won\} and Jung, \{Jae Chang\} and Lee, \{Gang Ho\} and Jongmin Lee and Yongmin Chang and Kim, \{Tae Jeong\}",

year = "2010",

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day = "1",

doi = "10.1016/j.bmcl.2010.02.002",

language = "English",

volume = "20",

pages = "2287--2291",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

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TY - JOUR

T1 - Gold nanoparticles functionalized by gadolinium-DTPA conjugate of cysteine as a multimodal bioimaging agent

AU - Park, Ji Ae

AU - Kim, Hee Kyung

AU - Kim, Joo Hyun

AU - Jeong, Sang Won

AU - Jung, Jae Chang

AU - Lee, Gang Ho

AU - Lee, Jongmin

AU - Chang, Yongmin

AU - Kim, Tae Jeong

PY - 2010/4/1

Y1 - 2010/4/1

N2 - The synthesis and characterization of gold nanoparticles coated with Gd-chelate (Au@GdL), where L is a conjugate of DTPA and cysteine, is described. These particles are obtained by the replacement of citrate from the gold nanoparticle surfaces with gadolinium chelate (GdL). The average size of Au@GdL is 14 nm with a loading of GdL reaching up to 2.9 × 103 per particles, and they demonstrate very high R1 relaxivity (∼105 mM-1 s-1) as well as X-ray attenuation. The R1 relaxivity per [Gd] is 17.9 mM-1 s-1. The present system also exhibits macrophage-specific property, as demonstrated by histological and TEM images as well as CT and MR, rendering itself as a new class of T1 multimodal CT/MR contrast agent.

AB - The synthesis and characterization of gold nanoparticles coated with Gd-chelate (Au@GdL), where L is a conjugate of DTPA and cysteine, is described. These particles are obtained by the replacement of citrate from the gold nanoparticle surfaces with gadolinium chelate (GdL). The average size of Au@GdL is 14 nm with a loading of GdL reaching up to 2.9 × 103 per particles, and they demonstrate very high R1 relaxivity (∼105 mM-1 s-1) as well as X-ray attenuation. The R1 relaxivity per [Gd] is 17.9 mM-1 s-1. The present system also exhibits macrophage-specific property, as demonstrated by histological and TEM images as well as CT and MR, rendering itself as a new class of T1 multimodal CT/MR contrast agent.

KW - DTPA-cysteine

KW - Gadolinium chelate

KW - Gold nanoparticles

KW - MRI-CT bimodality

KW - T1 agent

UR - https://www.scopus.com/pages/publications/77949489811

U2 - 10.1016/j.bmcl.2010.02.002

DO - 10.1016/j.bmcl.2010.02.002

M3 - Article

C2 - 20188545

AN - SCOPUS:77949489811

SN - 0960-894X

VL - 20

SP - 2287

EP - 2291

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 7

ER -

Gold nanoparticles functionalized by gadolinium-DTPA conjugate of cysteine as a multimodal bioimaging agent

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Keywords

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