Gold(III)-catalyzed cyanosilylation of ketones and aldehydes

Kyung Cho Woo; Min Kang Sung; Amiya K. Medda; Jungkyu K. Lee; Insung S. Choi; Hee Seung Lee

doi:10.1055/s-2008-1032154

Gold(III)-catalyzed cyanosilylation of ketones and aldehydes

Kyung Cho Woo, Min Kang Sung, Amiya K. Medda, Jungkyu K. Lee, Insung S. Choi, Hee Seung Lee

Korea Advanced Institute of Science and Technology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Gold(III) chloride was found to be a highly efficient catalyst for the cyanosilylation of various ketones and aldehydes. The reactions were complete within 30 minutes at room temperature in the presence of only one mol% gold(III) chloride, yielding the corresponding cyanohydrin trimethylsilyl ethers in very good yields. The isolated yields for the reactions of ketones were up to 98%, and the reactions of aldehydes gave 100% conversion, as monitored by ¹H NMR spectroscopy.

Original language	English
Pages (from-to)	507-510
Number of pages	4
Journal	Synthesis
Issue number	4
DOIs	https://doi.org/10.1055/s-2008-1032154
State	Published - 15 Feb 2008

Keywords

Aldehydes
Cyanohydrins
Homogeneous catalysis
Ketones
Transition metals

Access to Document

10.1055/s-2008-1032154

Cite this

@article{c1912e39424446d89c54ae6ee46fee2a,

title = "Gold(III)-catalyzed cyanosilylation of ketones and aldehydes",

abstract = "Gold(III) chloride was found to be a highly efficient catalyst for the cyanosilylation of various ketones and aldehydes. The reactions were complete within 30 minutes at room temperature in the presence of only one mol% gold(III) chloride, yielding the corresponding cyanohydrin trimethylsilyl ethers in very good yields. The isolated yields for the reactions of ketones were up to 98%, and the reactions of aldehydes gave 100% conversion, as monitored by 1H NMR spectroscopy.",

keywords = "Aldehydes, Cyanohydrins, Homogeneous catalysis, Ketones, Transition metals",

author = "Woo, {Kyung Cho} and Sung, {Min Kang} and Medda, {Amiya K.} and Lee, {Jungkyu K.} and Choi, {Insung S.} and Lee, {Hee Seung}",

year = "2008",

month = feb,

day = "15",

doi = "10.1055/s-2008-1032154",

language = "English",

pages = "507--510",

journal = "Synthesis",

issn = "0039-7881",

publisher = "Georg Thieme Verlag",

number = "4",

}

TY - JOUR

T1 - Gold(III)-catalyzed cyanosilylation of ketones and aldehydes

AU - Woo, Kyung Cho

AU - Sung, Min Kang

AU - Medda, Amiya K.

AU - Lee, Jungkyu K.

AU - Choi, Insung S.

AU - Lee, Hee Seung

PY - 2008/2/15

Y1 - 2008/2/15

N2 - Gold(III) chloride was found to be a highly efficient catalyst for the cyanosilylation of various ketones and aldehydes. The reactions were complete within 30 minutes at room temperature in the presence of only one mol% gold(III) chloride, yielding the corresponding cyanohydrin trimethylsilyl ethers in very good yields. The isolated yields for the reactions of ketones were up to 98%, and the reactions of aldehydes gave 100% conversion, as monitored by 1H NMR spectroscopy.

AB - Gold(III) chloride was found to be a highly efficient catalyst for the cyanosilylation of various ketones and aldehydes. The reactions were complete within 30 minutes at room temperature in the presence of only one mol% gold(III) chloride, yielding the corresponding cyanohydrin trimethylsilyl ethers in very good yields. The isolated yields for the reactions of ketones were up to 98%, and the reactions of aldehydes gave 100% conversion, as monitored by 1H NMR spectroscopy.

KW - Aldehydes

KW - Cyanohydrins

KW - Homogeneous catalysis

KW - Ketones

KW - Transition metals

UR - http://www.scopus.com/inward/record.url?scp=39749089322&partnerID=8YFLogxK

U2 - 10.1055/s-2008-1032154

DO - 10.1055/s-2008-1032154

M3 - Article

AN - SCOPUS:39749089322

SN - 0039-7881

SP - 507

EP - 510

JO - Synthesis

JF - Synthesis

IS - 4

ER -

Gold(III)-catalyzed cyanosilylation of ketones and aldehydes

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this