Gold(III)-catalyzed cyanosilylation of ketones and aldehydes

Kyung Cho Woo; Min Kang Sung; Amiya K. Medda; Jungkyu K. Lee; Insung S. Choi; Hee Seung Lee

doi:10.1055/s-2008-1032154

Gold(III)-catalyzed cyanosilylation of ketones and aldehydes

Kyung Cho Woo
, Min Kang Sung
, Amiya K. Medda
, Jungkyu K. Lee
, Insung S. Choi
, Hee Seung Lee

Korea Advanced Institute of Science and Technology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Gold(III) chloride was found to be a highly efficient catalyst for the cyanosilylation of various ketones and aldehydes. The reactions were complete within 30 minutes at room temperature in the presence of only one mol% gold(III) chloride, yielding the corresponding cyanohydrin trimethylsilyl ethers in very good yields. The isolated yields for the reactions of ketones were up to 98%, and the reactions of aldehydes gave 100% conversion, as monitored by ¹H NMR spectroscopy.

Original language	English
Pages (from-to)	507-510
Number of pages	4
Journal	Synthesis
Issue number	4
DOIs	https://doi.org/10.1055/s-2008-1032154
State	Published - 15 Feb 2008

Keywords

Aldehydes
Cyanohydrins
Homogeneous catalysis
Ketones
Transition metals

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title = "Gold(III)-catalyzed cyanosilylation of ketones and aldehydes",

abstract = "Gold(III) chloride was found to be a highly efficient catalyst for the cyanosilylation of various ketones and aldehydes. The reactions were complete within 30 minutes at room temperature in the presence of only one mol\% gold(III) chloride, yielding the corresponding cyanohydrin trimethylsilyl ethers in very good yields. The isolated yields for the reactions of ketones were up to 98\%, and the reactions of aldehydes gave 100\% conversion, as monitored by 1H NMR spectroscopy.",

keywords = "Aldehydes, Cyanohydrins, Homogeneous catalysis, Ketones, Transition metals",

author = "Woo, \{Kyung Cho\} and Sung, \{Min Kang\} and Medda, \{Amiya K.\} and Lee, \{Jungkyu K.\} and Choi, \{Insung S.\} and Lee, \{Hee Seung\}",

year = "2008",

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doi = "10.1055/s-2008-1032154",

language = "English",

pages = "507--510",

journal = "Synthesis",

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T1 - Gold(III)-catalyzed cyanosilylation of ketones and aldehydes

AU - Woo, Kyung Cho

AU - Sung, Min Kang

AU - Medda, Amiya K.

AU - Lee, Jungkyu K.

AU - Choi, Insung S.

AU - Lee, Hee Seung

PY - 2008/2/15

Y1 - 2008/2/15

N2 - Gold(III) chloride was found to be a highly efficient catalyst for the cyanosilylation of various ketones and aldehydes. The reactions were complete within 30 minutes at room temperature in the presence of only one mol% gold(III) chloride, yielding the corresponding cyanohydrin trimethylsilyl ethers in very good yields. The isolated yields for the reactions of ketones were up to 98%, and the reactions of aldehydes gave 100% conversion, as monitored by 1H NMR spectroscopy.

AB - Gold(III) chloride was found to be a highly efficient catalyst for the cyanosilylation of various ketones and aldehydes. The reactions were complete within 30 minutes at room temperature in the presence of only one mol% gold(III) chloride, yielding the corresponding cyanohydrin trimethylsilyl ethers in very good yields. The isolated yields for the reactions of ketones were up to 98%, and the reactions of aldehydes gave 100% conversion, as monitored by 1H NMR spectroscopy.

KW - Aldehydes

KW - Cyanohydrins

KW - Homogeneous catalysis

KW - Ketones

KW - Transition metals

UR - https://www.scopus.com/pages/publications/39749089322

U2 - 10.1055/s-2008-1032154

DO - 10.1055/s-2008-1032154

M3 - Article

AN - SCOPUS:39749089322

SN - 0039-7881

SP - 507

EP - 510

JO - Synthesis

JF - Synthesis

IS - 4

ER -

Gold(III)-catalyzed cyanosilylation of ketones and aldehydes

Abstract

Keywords

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