Abstract
Silybin has a potent antibacterial activity, more potent than silymarin II, against gram-positive bacteria without hemolytic activity, whereas it has no antimicrobial activity against gram-negative bacteria or fungi. The mode of action of silybin against the gram-positive bacterial cell was examined by investigating the change in plasma membrane dynamics of bacterial cells using 1,6-diphenyl-1,3,5-hextriene (DPH) as a membrane probe and by assessing the inhibition of macromolecular synthesis using radiolabeled incorporation assay. The results showed that silybin inhibited RNA and protein synthesis on gram-positive bacteria.
Original language | English |
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Pages (from-to) | 597-600 |
Number of pages | 4 |
Journal | Archives of Pharmacal Research |
Volume | 26 |
Issue number | 8 |
DOIs | |
State | Published - 30 Aug 2003 |
Keywords
- 1,6-Diphenyl-1,3,5-hextriene (DPH)
- Gram-positive bacteria
- Silybin