Gram-positive bacteria specific properties of silybin derived from Silybum marianum

Gun Lee Dong, Keun Kim Hyung, Yoonkyung Park, Seong Cheol Park, Eun Rhan Woo, Gwang Jeong Hye, Kyung Soo Hahm

Research output: Contribution to journalArticlepeer-review

62 Scopus citations

Abstract

Silybin has a potent antibacterial activity, more potent than silymarin II, against gram-positive bacteria without hemolytic activity, whereas it has no antimicrobial activity against gram-negative bacteria or fungi. The mode of action of silybin against the gram-positive bacterial cell was examined by investigating the change in plasma membrane dynamics of bacterial cells using 1,6-diphenyl-1,3,5-hextriene (DPH) as a membrane probe and by assessing the inhibition of macromolecular synthesis using radiolabeled incorporation assay. The results showed that silybin inhibited RNA and protein synthesis on gram-positive bacteria.

Original languageEnglish
Pages (from-to)597-600
Number of pages4
JournalArchives of Pharmacal Research
Volume26
Issue number8
DOIs
StatePublished - 30 Aug 2003

Keywords

  • 1,6-Diphenyl-1,3,5-hextriene (DPH)
  • Gram-positive bacteria
  • Silybin

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