Growth hormone-releasing hormone (GHRH) polymorphisms associated with carcass traits of meats in Korean cattle

Hyun Sub Cheong; Du Hak Yoon; Lyoung Hyo Kim; Byung Lae Park; Yoo Hyun Choi; Eui Ryong Chung; Yong Min Cho; Eng Woo Park; Il Cheong Cheong; Sung Jong Oh; Sung Gon Yi; Taesung Park; Hyoung Doo Shin

doi:10.1186/1471-2156-7-35

Growth hormone-releasing hormone (GHRH) polymorphisms associated with carcass traits of meats in Korean cattle

Hyun Sub Cheong, Du Hak Yoon, Lyoung Hyo Kim, Byung Lae Park, Yoo Hyun Choi, Eui Ryong Chung, Yong Min Cho, Eng Woo Park, Il Cheong Cheong, Sung Jong Oh, Sung Gon Yi, Taesung Park, Hyoung Doo Shin

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Abstract

Background: Cold carcass weight (CW) and longissimus muscle area (EMA) are the major quantitative traits in beef cattle. In this study, we found several polymorphisms of growth hormone-releasing hormone (GHRH) gene and examined the association of polymorphisms with carcass traits (CW and EMA) in Korean native cattle (Hanwoo). Results: By direct DNA sequencing in 24 unrelated Korean cattle, we identified 12 single nucleotide polymorphisms within the 9 kb full gene region, including the 1.5 kb promoter region. Among them, six polymorphic sites were selected for genotyping in our beef cattle (n = 428) and five marker haplotypes (frequency > 0.1) were identified. Statistical analysis revealed that -424/A>T showed significant associations with CW and EMA. Conclusion: Our findings suggest that polymorphisms in GHRH might be one of the important genetic factors that influence carcass yield in beef cattle. Sequence variation/haplotype information identified in this study would provide valuable information for the production of a commercial line of beef cattle.

Original language	English
Article number	35
Journal	BMC Genetics
Volume	7
DOIs	https://doi.org/10.1186/1471-2156-7-35
State	Published - 3 Jun 2006

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@article{736d1afab5094716876dbf4b40cb5077,

title = "Growth hormone-releasing hormone (GHRH) polymorphisms associated with carcass traits of meats in Korean cattle",

abstract = "Background: Cold carcass weight (CW) and longissimus muscle area (EMA) are the major quantitative traits in beef cattle. In this study, we found several polymorphisms of growth hormone-releasing hormone (GHRH) gene and examined the association of polymorphisms with carcass traits (CW and EMA) in Korean native cattle (Hanwoo). Results: By direct DNA sequencing in 24 unrelated Korean cattle, we identified 12 single nucleotide polymorphisms within the 9 kb full gene region, including the 1.5 kb promoter region. Among them, six polymorphic sites were selected for genotyping in our beef cattle (n = 428) and five marker haplotypes (frequency > 0.1) were identified. Statistical analysis revealed that -424/A>T showed significant associations with CW and EMA. Conclusion: Our findings suggest that polymorphisms in GHRH might be one of the important genetic factors that influence carcass yield in beef cattle. Sequence variation/haplotype information identified in this study would provide valuable information for the production of a commercial line of beef cattle.",

author = "Cheong, {Hyun Sub} and Yoon, {Du Hak} and Kim, {Lyoung Hyo} and Park, {Byung Lae} and Choi, {Yoo Hyun} and Chung, {Eui Ryong} and Cho, {Yong Min} and Park, {Eng Woo} and Cheong, {Il Cheong} and Oh, {Sung Jong} and Yi, {Sung Gon} and Taesung Park and Shin, {Hyoung Doo}",

year = "2006",

month = jun,

day = "3",

doi = "10.1186/1471-2156-7-35",

language = "English",

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journal = "BMC Genetics",

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T1 - Growth hormone-releasing hormone (GHRH) polymorphisms associated with carcass traits of meats in Korean cattle

AU - Cheong, Hyun Sub

AU - Yoon, Du Hak

AU - Kim, Lyoung Hyo

AU - Park, Byung Lae

AU - Choi, Yoo Hyun

AU - Chung, Eui Ryong

AU - Cho, Yong Min

AU - Park, Eng Woo

AU - Cheong, Il Cheong

AU - Oh, Sung Jong

AU - Yi, Sung Gon

AU - Park, Taesung

AU - Shin, Hyoung Doo

PY - 2006/6/3

Y1 - 2006/6/3

N2 - Background: Cold carcass weight (CW) and longissimus muscle area (EMA) are the major quantitative traits in beef cattle. In this study, we found several polymorphisms of growth hormone-releasing hormone (GHRH) gene and examined the association of polymorphisms with carcass traits (CW and EMA) in Korean native cattle (Hanwoo). Results: By direct DNA sequencing in 24 unrelated Korean cattle, we identified 12 single nucleotide polymorphisms within the 9 kb full gene region, including the 1.5 kb promoter region. Among them, six polymorphic sites were selected for genotyping in our beef cattle (n = 428) and five marker haplotypes (frequency > 0.1) were identified. Statistical analysis revealed that -424/A>T showed significant associations with CW and EMA. Conclusion: Our findings suggest that polymorphisms in GHRH might be one of the important genetic factors that influence carcass yield in beef cattle. Sequence variation/haplotype information identified in this study would provide valuable information for the production of a commercial line of beef cattle.

AB - Background: Cold carcass weight (CW) and longissimus muscle area (EMA) are the major quantitative traits in beef cattle. In this study, we found several polymorphisms of growth hormone-releasing hormone (GHRH) gene and examined the association of polymorphisms with carcass traits (CW and EMA) in Korean native cattle (Hanwoo). Results: By direct DNA sequencing in 24 unrelated Korean cattle, we identified 12 single nucleotide polymorphisms within the 9 kb full gene region, including the 1.5 kb promoter region. Among them, six polymorphic sites were selected for genotyping in our beef cattle (n = 428) and five marker haplotypes (frequency > 0.1) were identified. Statistical analysis revealed that -424/A>T showed significant associations with CW and EMA. Conclusion: Our findings suggest that polymorphisms in GHRH might be one of the important genetic factors that influence carcass yield in beef cattle. Sequence variation/haplotype information identified in this study would provide valuable information for the production of a commercial line of beef cattle.

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DO - 10.1186/1471-2156-7-35

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AN - SCOPUS:33746616863

SN - 1471-2156

VL - 7

JO - BMC Genetics

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ER -

Growth hormone-releasing hormone (GHRH) polymorphisms associated with carcass traits of meats in Korean cattle

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