Growth hormone-releasing hormone (GHRH) polymorphisms associated with carcass traits of meats in Korean cattle

Hyun Sub Cheong; Du Hak Yoon; Lyoung Hyo Kim; Byung Lae Park; Yoo Hyun Choi; Eui Ryong Chung; Yong Min Cho; Eng Woo Park; Il Cheong Cheong; Sung Jong Oh; Sung Gon Yi; Taesung Park; Hyoung Doo Shin

doi:10.1186/1471-2156-7-35

Growth hormone-releasing hormone (GHRH) polymorphisms associated with carcass traits of meats in Korean cattle

Hyun Sub Cheong
, Du Hak Yoon
, Lyoung Hyo Kim
, Byung Lae Park
, Yoo Hyun Choi
, Eui Ryong Chung
, Yong Min Cho
, Eng Woo Park
, Il Cheong Cheong
, Sung Jong Oh
, Sung Gon Yi
, Taesung Park
, Hyoung Doo Shin

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Background: Cold carcass weight (CW) and longissimus muscle area (EMA) are the major quantitative traits in beef cattle. In this study, we found several polymorphisms of growth hormone-releasing hormone (GHRH) gene and examined the association of polymorphisms with carcass traits (CW and EMA) in Korean native cattle (Hanwoo). Results: By direct DNA sequencing in 24 unrelated Korean cattle, we identified 12 single nucleotide polymorphisms within the 9 kb full gene region, including the 1.5 kb promoter region. Among them, six polymorphic sites were selected for genotyping in our beef cattle (n = 428) and five marker haplotypes (frequency > 0.1) were identified. Statistical analysis revealed that -424/A>T showed significant associations with CW and EMA. Conclusion: Our findings suggest that polymorphisms in GHRH might be one of the important genetic factors that influence carcass yield in beef cattle. Sequence variation/haplotype information identified in this study would provide valuable information for the production of a commercial line of beef cattle.

Original language	English
Article number	35
Journal	BMC Genetics
Volume	7
DOIs	https://doi.org/10.1186/1471-2156-7-35
State	Published - 3 Jun 2006

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@article{736d1afab5094716876dbf4b40cb5077,

title = "Growth hormone-releasing hormone (GHRH) polymorphisms associated with carcass traits of meats in Korean cattle",

abstract = "Background: Cold carcass weight (CW) and longissimus muscle area (EMA) are the major quantitative traits in beef cattle. In this study, we found several polymorphisms of growth hormone-releasing hormone (GHRH) gene and examined the association of polymorphisms with carcass traits (CW and EMA) in Korean native cattle (Hanwoo). Results: By direct DNA sequencing in 24 unrelated Korean cattle, we identified 12 single nucleotide polymorphisms within the 9 kb full gene region, including the 1.5 kb promoter region. Among them, six polymorphic sites were selected for genotyping in our beef cattle (n = 428) and five marker haplotypes (frequency > 0.1) were identified. Statistical analysis revealed that -424/A>T showed significant associations with CW and EMA. Conclusion: Our findings suggest that polymorphisms in GHRH might be one of the important genetic factors that influence carcass yield in beef cattle. Sequence variation/haplotype information identified in this study would provide valuable information for the production of a commercial line of beef cattle.",

author = "Cheong, \{Hyun Sub\} and Yoon, \{Du Hak\} and Kim, \{Lyoung Hyo\} and Park, \{Byung Lae\} and Choi, \{Yoo Hyun\} and Chung, \{Eui Ryong\} and Cho, \{Yong Min\} and Park, \{Eng Woo\} and Cheong, \{Il Cheong\} and Oh, \{Sung Jong\} and Yi, \{Sung Gon\} and Taesung Park and Shin, \{Hyoung Doo\}",

year = "2006",

month = jun,

day = "3",

doi = "10.1186/1471-2156-7-35",

language = "English",

volume = "7",

journal = "BMC Genetics",

issn = "1471-2156",

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TY - JOUR

T1 - Growth hormone-releasing hormone (GHRH) polymorphisms associated with carcass traits of meats in Korean cattle

AU - Cheong, Hyun Sub

AU - Yoon, Du Hak

AU - Kim, Lyoung Hyo

AU - Park, Byung Lae

AU - Choi, Yoo Hyun

AU - Chung, Eui Ryong

AU - Cho, Yong Min

AU - Park, Eng Woo

AU - Cheong, Il Cheong

AU - Oh, Sung Jong

AU - Yi, Sung Gon

AU - Park, Taesung

AU - Shin, Hyoung Doo

PY - 2006/6/3

Y1 - 2006/6/3

N2 - Background: Cold carcass weight (CW) and longissimus muscle area (EMA) are the major quantitative traits in beef cattle. In this study, we found several polymorphisms of growth hormone-releasing hormone (GHRH) gene and examined the association of polymorphisms with carcass traits (CW and EMA) in Korean native cattle (Hanwoo). Results: By direct DNA sequencing in 24 unrelated Korean cattle, we identified 12 single nucleotide polymorphisms within the 9 kb full gene region, including the 1.5 kb promoter region. Among them, six polymorphic sites were selected for genotyping in our beef cattle (n = 428) and five marker haplotypes (frequency > 0.1) were identified. Statistical analysis revealed that -424/A>T showed significant associations with CW and EMA. Conclusion: Our findings suggest that polymorphisms in GHRH might be one of the important genetic factors that influence carcass yield in beef cattle. Sequence variation/haplotype information identified in this study would provide valuable information for the production of a commercial line of beef cattle.

AB - Background: Cold carcass weight (CW) and longissimus muscle area (EMA) are the major quantitative traits in beef cattle. In this study, we found several polymorphisms of growth hormone-releasing hormone (GHRH) gene and examined the association of polymorphisms with carcass traits (CW and EMA) in Korean native cattle (Hanwoo). Results: By direct DNA sequencing in 24 unrelated Korean cattle, we identified 12 single nucleotide polymorphisms within the 9 kb full gene region, including the 1.5 kb promoter region. Among them, six polymorphic sites were selected for genotyping in our beef cattle (n = 428) and five marker haplotypes (frequency > 0.1) were identified. Statistical analysis revealed that -424/A>T showed significant associations with CW and EMA. Conclusion: Our findings suggest that polymorphisms in GHRH might be one of the important genetic factors that influence carcass yield in beef cattle. Sequence variation/haplotype information identified in this study would provide valuable information for the production of a commercial line of beef cattle.

UR - https://www.scopus.com/pages/publications/33746616863

U2 - 10.1186/1471-2156-7-35

DO - 10.1186/1471-2156-7-35

M3 - Article

C2 - 16749938

AN - SCOPUS:33746616863

SN - 1471-2156

VL - 7

JO - BMC Genetics

JF - BMC Genetics

M1 - 35

ER -

Growth hormone-releasing hormone (GHRH) polymorphisms associated with carcass traits of meats in Korean cattle

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