Heat-shock protein ClpL/HSP100 increases penicillin tolerance in streptococcus pneumoniae

Thao Dang Hien Tran, Hyog Young Kwon, Eun Hye Kim, Ki Woo Kim, David E. Briles, Suhkneung Pyo, Dong Kwon Rhee

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations

Abstract

Penicillin resistance and tolerance has been an increasing threat to the treatment of pneumococcal pneumoniae. However, no penicillin tolerance-related genes have been claimed. Here we show that a major heat shock protein ClpL/HSP100 could modulate the expression of a cell wall synthesis enzyme PBP2x, and subsequently increase cell wall thickness and penicillin tolerance in Streptococus pneumoniae.

Original languageEnglish
Title of host publicationRecent Advances in Tonsils and Mucosal Barriers of the Upper Airways
Subtitle of host publication7th International Symposium on Tonsils and Mucosal Barriers of the Upper Airways, Asahikawa, July 2010: Proceedings
EditorsYasuaki Harabuchi, Tatsuya Hayashi, Akihiro Katada
Pages126-128
Number of pages3
DOIs
StatePublished - Aug 2011

Publication series

NameAdvances in Oto-Rhino-Laryngology
Volume72
ISSN (Print)0065-3071

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