Heparin-immobilized gold-assisted controlled release of growth factors: Via electrochemical modulation

Boyoung Kim; Kihak Gwon; Seyeong Lee; Young Ha Kim; Myung Han Yoon; Giyoong Tae

doi:10.1039/c6ra18908c

Heparin-immobilized gold-assisted controlled release of growth factors: Via electrochemical modulation

Boyoung Kim
, Kihak Gwon
, Seyeong Lee
, Young Ha Kim
, Myung Han Yoon
, Giyoong Tae

Department of Biofibers and Biomaterials Science

Gwangju Institute of Science and Technology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We developed a versatile platform for the electrochemical release of growth factors assisted by a heparin-immobilized gold surface. The controlled release of basic fibroblast growth factor (bFGF) from heparinized gold could be effectively modulated by biphasic electrochemical stimulation which actively controlled specific interactions between heparin and bFGF in a remote manner so that the released bFGF maintained its bioactivity.

Original language	English
Pages (from-to)	88038-88041
Number of pages	4
Journal	RSC Advances
Volume	6
Issue number	91
DOIs	https://doi.org/10.1039/c6ra18908c
State	Published - 2016

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10.1039/c6ra18908c

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title = "Heparin-immobilized gold-assisted controlled release of growth factors: Via electrochemical modulation",

abstract = "We developed a versatile platform for the electrochemical release of growth factors assisted by a heparin-immobilized gold surface. The controlled release of basic fibroblast growth factor (bFGF) from heparinized gold could be effectively modulated by biphasic electrochemical stimulation which actively controlled specific interactions between heparin and bFGF in a remote manner so that the released bFGF maintained its bioactivity.",

author = "Boyoung Kim and Kihak Gwon and Seyeong Lee and Kim, \{Young Ha\} and Yoon, \{Myung Han\} and Giyoong Tae",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",

year = "2016",

doi = "10.1039/c6ra18908c",

language = "English",

volume = "6",

pages = "88038--88041",

journal = "RSC Advances",

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publisher = "Royal Society of Chemistry",

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T1 - Heparin-immobilized gold-assisted controlled release of growth factors

T2 - Via electrochemical modulation

AU - Kim, Boyoung

AU - Gwon, Kihak

AU - Lee, Seyeong

AU - Kim, Young Ha

AU - Yoon, Myung Han

AU - Tae, Giyoong

PY - 2016

Y1 - 2016

N2 - We developed a versatile platform for the electrochemical release of growth factors assisted by a heparin-immobilized gold surface. The controlled release of basic fibroblast growth factor (bFGF) from heparinized gold could be effectively modulated by biphasic electrochemical stimulation which actively controlled specific interactions between heparin and bFGF in a remote manner so that the released bFGF maintained its bioactivity.

AB - We developed a versatile platform for the electrochemical release of growth factors assisted by a heparin-immobilized gold surface. The controlled release of basic fibroblast growth factor (bFGF) from heparinized gold could be effectively modulated by biphasic electrochemical stimulation which actively controlled specific interactions between heparin and bFGF in a remote manner so that the released bFGF maintained its bioactivity.

UR - https://www.scopus.com/pages/publications/84988421898

U2 - 10.1039/c6ra18908c

DO - 10.1039/c6ra18908c

M3 - Article

AN - SCOPUS:84988421898

SN - 2046-2069

VL - 6

SP - 88038

EP - 88041

JO - RSC Advances

JF - RSC Advances

IS - 91

ER -

Heparin-immobilized gold-assisted controlled release of growth factors: Via electrochemical modulation

Abstract

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