Hepatic protective effects of sulforaphane through the modulation of inflammatory pathways

Changhun Lee; Sumin Yang; Bong Seon Lee; So Yeon Jeong; Kyung Min Kim; Sae Kwang Ku; Jong Sup Bae

doi:10.1080/10286020.2019.1581174

Hepatic protective effects of sulforaphane through the modulation of inflammatory pathways

Changhun Lee, Sumin Yang, Bong Seon Lee, So Yeon Jeong, Kyung Min Kim, Sae Kwang Ku, Jong Sup Bae

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The aim of this study was to investigate the effects of sulforaphane (SFN) on lipopolysaccharide (LPS)-induced liver failure, and to elucidate underlying mechanisms. SFN, a natural isothiocyanate present in cruciferous vegetables such as broccoli and cabbage, is effective in preventing carcinogenesis, diabetes, and inflammatory responses. Mice were treated intravenously with SFN at 12 h after LPS treatment. LPS significantly increased mortality, serum levels of liver damage markers, and inflammatory cytokines, and toll-like receptor 4 (TLR4) protein expression, which were reduced by SFN. Our results suggest that SFN protects against LPS-induced liver damage, indicating its potential to treat liver diseases.

Original language	English
Pages (from-to)	386-396
Number of pages	11
Journal	Journal of Asian Natural Products Research
Volume	22
Issue number	4
DOIs	https://doi.org/10.1080/10286020.2019.1581174
State	Published - 2 Apr 2020

Keywords

inflammation
lipopolysaccharide
liver failure
Sulforaphane
toll-like receptor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/10286020.2019.1581174

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title = "Hepatic protective effects of sulforaphane through the modulation of inflammatory pathways",

abstract = "The aim of this study was to investigate the effects of sulforaphane (SFN) on lipopolysaccharide (LPS)-induced liver failure, and to elucidate underlying mechanisms. SFN, a natural isothiocyanate present in cruciferous vegetables such as broccoli and cabbage, is effective in preventing carcinogenesis, diabetes, and inflammatory responses. Mice were treated intravenously with SFN at 12 h after LPS treatment. LPS significantly increased mortality, serum levels of liver damage markers, and inflammatory cytokines, and toll-like receptor 4 (TLR4) protein expression, which were reduced by SFN. Our results suggest that SFN protects against LPS-induced liver damage, indicating its potential to treat liver diseases.",

keywords = "inflammation, lipopolysaccharide, liver failure, Sulforaphane, toll-like receptor",

author = "Changhun Lee and Sumin Yang and Lee, {Bong Seon} and Jeong, {So Yeon} and Kim, {Kyung Min} and Ku, {Sae Kwang} and Bae, {Jong Sup}",

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T1 - Hepatic protective effects of sulforaphane through the modulation of inflammatory pathways

AU - Lee, Changhun

AU - Yang, Sumin

AU - Lee, Bong Seon

AU - Jeong, So Yeon

AU - Kim, Kyung Min

AU - Ku, Sae Kwang

AU - Bae, Jong Sup

PY - 2020/4/2

Y1 - 2020/4/2

N2 - The aim of this study was to investigate the effects of sulforaphane (SFN) on lipopolysaccharide (LPS)-induced liver failure, and to elucidate underlying mechanisms. SFN, a natural isothiocyanate present in cruciferous vegetables such as broccoli and cabbage, is effective in preventing carcinogenesis, diabetes, and inflammatory responses. Mice were treated intravenously with SFN at 12 h after LPS treatment. LPS significantly increased mortality, serum levels of liver damage markers, and inflammatory cytokines, and toll-like receptor 4 (TLR4) protein expression, which were reduced by SFN. Our results suggest that SFN protects against LPS-induced liver damage, indicating its potential to treat liver diseases.

AB - The aim of this study was to investigate the effects of sulforaphane (SFN) on lipopolysaccharide (LPS)-induced liver failure, and to elucidate underlying mechanisms. SFN, a natural isothiocyanate present in cruciferous vegetables such as broccoli and cabbage, is effective in preventing carcinogenesis, diabetes, and inflammatory responses. Mice were treated intravenously with SFN at 12 h after LPS treatment. LPS significantly increased mortality, serum levels of liver damage markers, and inflammatory cytokines, and toll-like receptor 4 (TLR4) protein expression, which were reduced by SFN. Our results suggest that SFN protects against LPS-induced liver damage, indicating its potential to treat liver diseases.

KW - inflammation

KW - lipopolysaccharide

KW - liver failure

KW - Sulforaphane

KW - toll-like receptor

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DO - 10.1080/10286020.2019.1581174

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Hepatic protective effects of sulforaphane through the modulation of inflammatory pathways

Abstract

Keywords

UN SDGs

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